Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls

Jacob, Elena; Braun, Janina; Oelmeier, Kathrin; Köster, Helen Ann; Möllers, Mareike; Falkenberg, Maria; Klockenbusch, Walter; Schmitz, Ralf; Hammer, K

doi:10.1515/jpm-2019-0401

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Axial views of the head were extracted from archived sonographic scans to determine the CSP width. One observer measured the CSP in its center, perpendicular to the brain's axis, placing the calipers on the inside of its lateral borders, as described by Abele et al (cited by Jacob et al) 18 In order to obtain parameters independent of the actual size of the fetus, the quotients HC/CSP, were calculated.…”

Section: Resultsmentioning

confidence: 99%

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Silva

Pérez

2021

Rev Bras Ginecol Obstet

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Fetal growth restriction (FGR) occurs when the fetus does not reach its intrauterine potential for growth and development as a result of compromise in placental function. It is a condition that affects 5 to 10% of pregnancies and is the second most common cause of perinatal morbidity and mortality. Children born with FGR are at risk of impaired neurological and cognitive development and cardiovascular or endocrine diseases in adulthood. The purpose of the present revision is to perform a literature search for evidence on the detection and assessment by ultrasound of brain injury linked to FGR during fetal life. Using a systematic approach and quantitative evaluation as study methodology, we reviewed ultrasound studies of the fetal brain structure of growth-restricted fetuses with objective quality measures. A total of eight studies were identified. High quality studies were identified for measurement of brain volumes; corpus callosum; brain fissure depth measurements, and cavum septi pellucidi width measurement. A low-quality study was available for transverse cerebellar diameter measurement in FGR. Further prospective randomized studies are needed to understand the changes that occur in the brain of fetuses with restricted growth, as well as their correlation with the changes in cognitive development observed.

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Section: Resultsmentioning

confidence: 99%

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Silva

Pérez

2021

Rev Bras Ginecol Obstet

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“…Possible accounts of NDI caused by PE: in this study, the PE group had a higher birth probability of SGA. One study has found differences in brain development between SGA and normal control fetuses [ 21 ]. And, some scholars hold that PE may contribute to the birth rate of SGA and that it is closely related to placental function [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Diffusion Tensor Imaging for Infants’ Brain Development Retardation Caused by Pre-Eclampsia

Xing

Liu

Xuan

et al. 2021

Contrast Media & Molecular Imaging

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Objective. Pre-eclampsia (PE) can cause brain development delay in infants. This work aims to characterize the pattern differences of brain white matter development in premature infants under PE conditions and those without. Methods. Eighty preterm infants delivered by women with PE were selected as the PE group, and ninety-six preterm infants of the same period born to women without high-risk perinatal factors were used as control. All infants underwent diffusion tensor imaging (DTI) examination. The fractional anisotropy (FA) was measured in five regions of interests (ROIs), including posterior limbs of internal capsule (PLIC), splenium of the corpus callosum (SCC), superior frontal gyrus (SFG), superior parietal lobule (SPL), and superior occipital gyrus (SOG). The relationship between the FA values and postmenstrual age (PMA) was analyzed. Results. After adjusting for the birth weight and gestational ages, in the SCC and PLIC, the PMA and FA values showed a low-to-medium intensity positive correlation in the control group (r = 0.30, p = 0.003 ; r = 0.53, p < 0.0001 ), while no positive relevance was detected in the PE group (r = 0.08, p = 0.47 ; r = 0.19, p < 0.08 ). In the PE and control groups, in the SPL and SOG, the PMA and FA values showed a near-consistent positive correlation (r = 0.57, r = 0.55 vs. r = 0.31, r = 0.55; all p < 0.05 ). In the control group, in SFG, the PMA and FA values had a medium intensity positive correlation (r = 0.47, p < 0.0001 ), but there was no statistical difference in correlation in PE (r = 0.10, p = 0.39 ). Conclusion. PE may cause lagging brain development in the SCC, PLIC, and SFG during infancy. DTI may be an effective and sensitive detection tool.

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Prevalence of autism spectrum disorder diagnosis by birth weight, gestational age, and size for gestational age: a systematic review, meta-analysis, and meta-regression

Guo

Zhai

et al. 2022

Eur Child Adolesc Psychiatry

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Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls

Cited by 4 publications

References 23 publications

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Diagnostic Value of Diffusion Tensor Imaging for Infants’ Brain Development Retardation Caused by Pre-Eclampsia

Prevalence of autism spectrum disorder diagnosis by birth weight, gestational age, and size for gestational age: a systematic review, meta-analysis, and meta-regression

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