Fetal bladder morphology may predict neonatal outcomes in fetal lower urinary tract obstruction (LUTO)

Shannon, Kara J.; VanLoh, Sarah; Espinoza, Jimmy; Cortes, M. Sanz; Donepudi, Roopali; Shamshirsaz, Alireza A.; Koh, Chester J.; Roth, David B.; Braun, Michael C.; Angelo, Joseph; Belfort, Michael A.; Nassr, Ahmed A.

doi:10.1016/j.ajog.2022.11.307

Cited by 2 publications

(2 citation statements)

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“…After clinical assessment, patients were categorized as "favorable" or "unfavorable" for fetal intervention by integrating imaging and urine biochemistry as previously described. 11 Either Harrison or Rocket vesico-amniotic shunts were utilized at the discretion of the surgeon and product availability. After shunt placement, patients were evaluated weekly by ultrasonography to assess dislodgement and renal function.…”

Section: Fetal Interventionmentioning

confidence: 99%

Outcomes of fetal lower urinary tract obstruction based on timing of oligohydramnios onset

Munoz,

Tounsi,

Buskmiller

et al. 2023

Prenatal Diagnosis

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ObjectiveFetal Lower Urinary Tract Obstruction (LUTO) is associated with oligohydramnios and significant fetal morbidity, resulting in poor lung development and perinatal death. However, oligohydramnios may develop at different gestational periods, and the impact of timing on fetal outcomes remains unknown. Our objective was to characterize the impact onset of oligohydramnios had on prenatal outcomes.MethodsThis study is a retrospective cohort study of all patients with a prenatal diagnosis of LUTO at our tertiary referral center from 2014 to 2023. All patients underwent detailed ultrasonography and interdisciplinary counseling and were subsequently delivered at our institution. Data were obtained from electronic medical records and complete extraction was required for final inclusion.ResultsDuring the study time period, 93 patients met inclusion criteria of which 68 (73.1%) developed oligohydramnios during their pregnancy. 63 (93%) of these pregnancies resulted in livebirths with 28 (41.1%) perinatal deaths. Onset of oligohydramnios was earlier in pregnancies with perinatal death (23 vs. 28 weeks, p = 0.004) and associated with pulmonary hypoplasia.ConclusionsOur data show the impact of oligohydramnios timing in pregnancy on pulmonary hypoplasia and ultimately perinatal death. This allows for detailed patient counseling on the impact oligohydramnios may have on pregnancies by the gestational age of onset.

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Section: Fetal Interventionmentioning

confidence: 99%

Outcomes of fetal lower urinary tract obstruction based on timing of oligohydramnios onset

Munoz,

Tounsi,

Buskmiller

et al. 2023

Prenatal Diagnosis

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show abstract

“…This is in sharp contrast to the contents of the current issue on the ‘Prenatal diagnosis, management and outcomes for urinary tract conditions’, where the emphasis is very clearly focused on defining the underlying genetic aetiology of renal anomalies to aid prenatal counselling, prognosis and clinical management as well as the introduction of novel therapies. We do include some studies describing sonographic features that may help predict prognosis in foetuses with lower urinary tract obstruction 1–3 . Nowadays large cohort studies and systematic reviews are forthcoming that bring to light which types of renal tract anomalies are most commonly associated with chromosomal copy number variants and which associate with monogenic conditions 4 .…”

Section: Introductionmentioning

confidence: 99%

Twenty years of progress in the diagnosis and management of foetal urinary tract conditions

Blakemore,

Chitty

2024

Prenatal Diagnosis

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Fetal bladder morphology may predict neonatal outcomes in fetal lower urinary tract obstruction (LUTO)

Cited by 2 publications

References 0 publications

Outcomes of fetal lower urinary tract obstruction based on timing of oligohydramnios onset

Outcomes of fetal lower urinary tract obstruction based on timing of oligohydramnios onset

Twenty years of progress in the diagnosis and management of foetal urinary tract conditions

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