Fetal and obstetrics manifestations of mitochondrial diseases
Adelizzi Alessia,
Giri Anastasia,
Di Donfrancesco Alessia
et al.
Abstract:During embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health. Therefore, perturbation on mitochondrial function can have a pathological effect on pregnancy. Several shreds of evidence collected in preclinical models revealed that severe mitochondrial dysfunction is incompatible with life or leads to critical developmental defects, highlig… Show more
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