Fetal and neonatal hepatic tumors

Isaacs, Hart

doi:10.1016/j.jpedsurg.2007.07.047

Cited by 219 publications

(170 citation statements)

References 19 publications

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“…: BeckwithWiedemann syndrome) or maternal disease (e.g. : anaemia, diabetes), the congenital malignancies may cause placental enlargement [4,5]. Most frequent chromosomal abnormalities, including Down syndrome, more often associated with this diagnose, were excluded.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnostic criteria for congenital leukaemia include proliferation of immature leucocytes, infiltration into the extra haematopoietic tissue and absence of diseases that can cause leukaemia or leucoerythroblastic reactions [4,5]. Moreover, genetic or chromosomal disorders that may be associated with unstable haematopoiesis, such as trisomy 21, leukemoid reactions and blood group incompatibility must be distinguished from acute leukemia [6].…”

Section: Discussionmentioning

confidence: 99%

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Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x

Oliveira¹,

Caldas²

2015

J Preg Child Health

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The authors describe a case of congenital acute lymphoblastic leukaemia (ALL), with extensive placental involvement, causing intrauterine fetal growth restriction and unexpected fetal demise at 33 weeks. Although unusual, other congenital tumours, including neuroblastoma and hepatoblastoma, can metastasize to the placenta. Congenital malignancy must be considered in the differential diagnosis of an abnormally large placenta. This case emphasizes the important role of careful histopathologic examination of the placenta which, combined with immunohistochemistry and clinicopathologic correlation, may establish the accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x

Oliveira¹,

Caldas²

2015

J Preg Child Health

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“…В отли-чие от взрослых, у которых тромбоз воротной вены выявляется у 8,4 % пациентов с гепатоцеллюлярным раком [10][11][12][13], данные по распространенности тром-бозов воротной вены у детей со ЗНО печени представ-лены единичными работами [14][15][16]. Это может быть обусловлено низкой распространенностью ЗНО пече-ни в педиатрической практике -1 % среди всех солид-ных ЗНО [16].…”

Section: обзор литературыunclassified

Portal vein thrombosis in a patient with a malignant rhabdoid tumor of the liver (Case report)

Наумова¹

2015

Ross. ž. det. gematol. onkol.

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“…34 Hepatocellular carcinoma typically occurs in individuals with preexisting chronic hepatic disease from viral infections or toxin exposure or from metabolic storage disease. 16 Neoplastic hepatocytes may revert to production of proteins not normally produced postnatally, such as a-fetoprotein (AFP). Detection of AFP has utility as an immunohistochemical (IHC) tumor marker for diagnosis, and serum concentration is useful in both diagnosis and assessment of response to therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Detection of AFP has utility as an immunohistochemical (IHC) tumor marker for diagnosis, and serum concentration is useful in both diagnosis and assessment of response to therapy. 5,10,12,16,38 Primary equine liver tumors are rare, with only 17 cases reported, of which 9 were classified as HB (Table 1). 3,4,8,13,18,19,21,22,24,27,29,32,33,35 Other reports of primary hepatic tumors in fetuses and juvenile horses included mixed hamartoma, 33 mesenchymal hamartoma, 4 and HCC.…”

Section: Introductionmentioning

confidence: 99%

Equine Primary Liver Tumors: A Case Series and Review of the Literature

et al. 2010

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Abstract. Hepatoblastoma (HB) is an uncommon pediatric liver tumor in humans and horses. In humans, HB is most frequently diagnosed in fetuses, neonates, and young children, whereas hepatocellular carcinoma (HCC) affects juvenile and adult humans. Hepatoblastoma in the horse is rare, with only 9 reported cases. Affected horses ranged in age from late-term aborted fetuses to 3 years. The current study describes 3 new cases of primary liver tumors in horses and reviews findings in relation to other reports on this condition. Tumors classified as HB were identified in a male Standardbred aborted fetus and in a 4-year-old Thoroughbred filly. Hepatocellular carcinoma was diagnosed in a 15-month-old Paint filly. In the Standardbred fetus, the tumor was only present in the liver. In the Thoroughbred and Paint fillies, primary tumors were in the right liver lobe and at the hilus, respectively, and there were metastases to other lobes (HB) and mesenteric lymph nodes (HCC). Tumors were sharply demarcated from adjacent tissue, nonencapsulated, compressive, and invasive. Consisting of cords and nests, or disorganized sheets of epithelial cells, tumors had variable stromal and vascular components. The fetal tumor contained areas of smaller, less differentiated cells with a pronounced mesenchymal component interpreted to be embryonal hepatic tissue. Diagnoses were based on tumor histomorphologic features, resemblance to hepatocyte developmental stages, age of the animal, and patterns of metastasis. Tumors classified as HB were a-fetoprotein immunoreactive. Primary hepatic tumors in the horse are diverse in morphology and include subtypes compatible with classification criteria applied to human tumors.

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Fetal and neonatal hepatic tumors

Cited by 219 publications

References 19 publications

Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x

Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x

Portal vein thrombosis in a patient with a malignant rhabdoid tumor of the liver (Case report)

Equine Primary Liver Tumors: A Case Series and Review of the Literature

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