Fetal and maternal serum copper and zinc levels in human pregnancy

Dreosti, Ivor E.; McMichael, Anthony J.; Gibson, G. T.; Buckley, R.A.; Hartshorhe, J.M.; Colley, D. P.

doi:10.1016/s0271-5317(82)80071-7

Cited by 19 publications

(4 citation statements)

References 19 publications

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“…Maternal serum Zn levels decline 15-35% by late pregnancy to around 48.5 ± 17.6 µg/dL but remain high in cord blood as Zn is actively transported across the placenta and transferred to the fetus (Dreosti et al, 1982;Wasowicz et al 2001;Ofakunrin et al, 2017). In the last trimester, Zn levels in the fetus increase to around 99.3 ± 21.5 µg/dL and are maintained at constantly higher than maternal levels (Terrin et al, 2015;Ofakunrin et al, 2017).…”

Section: Zinc In Enamel and Dentinementioning

confidence: 99%

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Dean

Spiers

Garrevoet

et al. 2019

Archives of Oral Biology

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Objectives: Our first objective was to review the evidence describing the appearance and microstructure of the neonatal line and to link this with known changes in neonatal physiology occurring at and around birth. A second objective was to explore ways to improve identification of the neonatal line by mapping the pre-and postnatal distribution of Ca, Sr and Zn in deciduous cuspal enamel and superimposing these maps onto transmitted light micrographs that included a clear true section of the neonatal line. Materials and Methods: We used synchrotron X-ray fluorescence to map elemental distributions in pre-and postnatal enamel and dentine. Two deciduous canines and 5 molars were scanned with an X-ray beam monochromatised to 17.0 keV at either 10.0, 2.5 or 1.0 µm resolution and 10 ms integration time. Results: Calcium maps distinguished enamel and dentine but did not clearly demarcate tissues formed pre-or postnatally. Strontium maps reflected presumed pre-and postnatal maternal serum levels and what are likely to be diet-dependent regions of Sr enrichment or depletion. Prenatal Zn maps, particularly for dentine, mirror elevated levels in the fetus and in colostrum during the first few days of life. Conclusions: The neonatal line, enamel dentine junction and surface enamel were all Zn-rich. Within the neonatal line Zn may be associated with increased crystallinity but also with caries resistance, both of which have been reported previously. Elemental mapping may improve the identification of ambiguous NNLs and so be useful in forensic and archaeological studies.

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Section: Zinc In Enamel and Dentinementioning

confidence: 99%

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Dean

Spiers

Garrevoet

et al. 2019

Archives of Oral Biology

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“…In the present study mean concentration of Zn in pregnant females was 51.9±61ppm significantly different than control group. Maternal serum Zn concentrations correlated negatively with gestational age (McMichael et al, 1982). Zn levels were lower in pregnant than in nonpregnant women (Dreosti et al, 1982).…”

Section: Discussionmentioning

confidence: 88%

“…Maternal serum Zn concentrations correlated negatively with gestational age (McMichael et al, 1982). Zn levels were lower in pregnant than in nonpregnant women (Dreosti et al, 1982). In elderly individuals deficiency of Zn causes T-lymphocyte impairments and cellular immunity reduction (Chernoff, 2005).…”

Section: Discussionmentioning

confidence: 97%

Level of serum heavy metal concentration in pregnant and non-pregnant women of district Sargodha: A comparative study

2017

Int. J. Biosci.

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In present study, level of some heavy metals was evaluated among pregnant females living in industrial areas and compared with non-pregnant females in University of Sargodha. Blood samples were collected from females of different age group. The samples were processed through wet acid digestion and flame Atomic Absorption Spectroscopy was used for comparison. The mean values of blood Pb (104.4±78.1ppm), Zn (51.9±61ppm), Cd (31.2±19.9ppm) and Cr (10.5±10.7ppm) was significantly higher in pregnant females as compared to nonpregnant females. The present study concludes that increased blood level of Pb, Cd, Cr and decrease level of Cu may be a risk factor for pregnant females.

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“…(1) The existing relation between zinc and pregnancy: it has been proved, both in animal experimentation and in man, that zinc defi ciency during pregnancy can cause congenital malformations (especially in the central ner vous system and the skeleton), an increase in the incidence of abortion and intrauterine un derdevelopment [2][3][4], Low levels of zinc during pregnancy have been attributed to multiple causes: expansion of plasmatic volume [5,6], oestrogen increase [7][8][9], alterations in the binding affinity of zinc to proteins [10,11 ] or the increase in fetal requirements [6,10,12], However, the real meaning of this phenomenon and its relation to a possible teratogenesis are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Zinc-Binding Capacity during Childbirth, in Newborn Infants and during the Menstrual Cycle

et al. 1994

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This is a study of the value of total serum zinc, serum zinc per g of protein, serum zinc-binding capacity and serum zinc-binding capacity per g of protein in 102 pregnant women during childbirth and in the cord blood of their newborn infants. A control group is established by analyzing these parameters in 10 healthy non-pregnant women on the first day of menstruation and on the day of ovulation during two consecutive menstrual cycles. The total serum zinc and serum zinc per g of protein values found were significantly higher in cord blood than in maternal blood, and the binding capacity of zinc and of zinc per g protein were significantly higher in maternal blood. There is a negative correlation between total zinc and binding capacity and total zinc and binding capacity per g protein both in maternal and in cord blood. In the control group, the values of total zinc and zinc per g protein vary from one menstrual cycle to the next and between the different phases of each cycle. Zinc-binding capacity per g protein during ovulation is significantly lower than during menstruation. These results allow us to conclude that the rise of zinc-binding capacity and zinc-binding capacity per g protein in maternal blood during childbirth, and during menstruation in the control group, can be due to the effect of progesterone. The fact that zinc-binding capacity and zinc-binding capacity per g of protein are higher in maternal blood than in cord blood would confirm the existence of mechanisms which tend to increase binding of zinc in the fetus.

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Fetal and maternal serum copper and zinc levels in human pregnancy

Cited by 19 publications

References 19 publications

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Level of serum heavy metal concentration in pregnant and non-pregnant women of district Sargodha: A comparative study

Evaluation of Serum Zinc-Binding Capacity during Childbirth, in Newborn Infants and during the Menstrual Cycle

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