Fetal and maternal risk factors in herpes gestationis

Lawley, T. J.

doi:10.1001/archderm.114.4.552

Cited by 57 publications

(61 citation statements)

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“…14 Cases of small for age babies and preterm deliveries have also been reported in patients of HG. 15 None of our cases reported any grave fetal outcome. Maternal morbidity was limited to pruritus which caused severe distress in a small number of patients of PP and ICP .…”

mentioning

confidence: 67%

Specific Pregnancy Dermatoses in 1430 females from Northern India

Chander¹,

Garg²,

Kakkar³

et al. 2011

J Dermatol Case Rep

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Background: The specific dermatoses of pregnancy represent a heterogenous group of ill-defined pruritic skin diseases, unique to pregnancy and post partum period. Objective:The aim of our study was epidemiological and clinical evaluation of various specific dermatoses of pregnancy.Methods: All patients visiting our antenatal clinic were screened for various pruritic skin conditions and those with specific pregnancy dermatoses were identified and evaluated. Results:Out of 1430 patients screened, nearly 5% (70 cases) patients had specific dermatoses of pregnancy. Intra hepatic cholestasis was the commonest specific pregnancy dermatoses. Conclusion:Specific dermatoses of pregnancy can be diagnosed primarily on the basis of clinical features. All of these, except intra hepatic cholestasis, do not have any effect on normal course of pregnancy. (J Dermatol Case Rep.

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mentioning

confidence: 67%

Specific Pregnancy Dermatoses in 1430 females from Northern India

Chander¹,

Garg²,

Kakkar³

et al. 2011

J Dermatol Case Rep

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“…As a result, 5-10% of the newborns show urticarial, vesicular or bullous lesions. In the skin of uninvolved infants, deposition of C3 and IgG along the dermalepidermal junction may be demonstrated by direct immunofluorescence microscopy 5,6 . The lesions invariably resolve during the first few weeks after delivery and usually do not require any treatment 11 .…”

Section: Fetal Risksmentioning

confidence: 99%

“…In more severe cases, the administration initially of 0.3 -0.5 mg prednisolone per kilogram body weight daily is generally sufficient. This dose can usually be decreased during the course of the disease 1,5,15 . Flareups postpartum may require a temporary increase of the corticosteroid dose 11 .…”

Section: Treatmentmentioning

confidence: 99%

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Shimanovich

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…One such antigen is the 180-kD protein (referred to here as BPI 80 antigen), which is recognized by -50% of all BP sera and the majority of Herpes Gestationis (HG) sera (13). HG is an idiopathic subepidermal disease of pregnancy which exhibits several features common to BP, including the presence of anti-BMZ autoantibodies (14).…”

mentioning

confidence: 99%

Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome.

Díaz¹,

Ratrie²,

Saunders³

et al. 1990

J. Clin. Invest.

344

185

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Autoantibodies present in the sera of patients with bullous pemphigoid (BP) bind to the basement membrane zone of normal human skin and commonly recognize two epidermal proteins, the BP240 and BP180 antigens. Two BP antigen cDNA clones from a lambda gtl1 human keratinocyte library have been identified on the basis of reactivity with a BP serum. The fusion protein (FP) produced by one clone immunoadsorbed autoantibodies, which specifically recognized the BP180 antigen, showing no cross-reactivity with BP240 by immunoblot analysis. The FP produced by the second clone immunoadsorbed autoantibodies which specifically reacted with the BP240 epidermal antigen. Northern blot analysis demonstrated that the BP180 and BP240 antigens are encoded by distinct RNA transcripts with lengths of 6.0 and 8.5 kb, respectively. Immunoblot analysis of the BP180 lysogen extract identified a 135-kD FP which was recognized by 7 of 16 BP sera and 7 of 8 herpes gestationis sera. A rabbit antiserum prepared against the lysogenic BP180 FP specifically recognized the BP180 antigen from human epidermal extracts by immunoblotting, labeled the BMZ by indirect immunofluorescence, and bound to human epidermal hemidesmosomes by immuno-electron microscopy. These results indicate that the BP180 antigen recognized by BP and herpes gestationis autoantibodies is a unique hemidesmosomal polypeptide, distinguishable from the BP240 antigen. (J. Clin. Invest. 1990.

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Fetal and maternal risk factors in herpes gestationis

Cited by 57 publications

References 0 publications

Specific Pregnancy Dermatoses in 1430 females from Northern India

Specific Pregnancy Dermatoses in 1430 females from Northern India

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome.

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