Fetal and Maternal Effects of Sodium Nitroprusside Used to Counteract Hypertension in Gravid Ewes

Ellis, Spencer; Wheeler, Andrew A.; James, Francis M.; Rose, James C.; Meis, Paul J.; Shihabi, Zak K.; Greiss, Frank C.; Urban, R. B.

doi:10.1097/00132582-198303000-00008

Cited by 5 publications

(8 citation statements)

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“…Further confirmation of the lack of morbidity of low dose SNp I8 is given by Ellis et al 26 who used SNP to reverse the 20070 blood pressure rise resulting from a noradrenaline infusion into gravid ewes. No foetal or maternal compromise occurred with SNP at 2.3 /-lg/kg/min.…”

Section: Snp In Pregnancymentioning

confidence: 87%

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Sodium Nitroprusside, Pregnancy and Multiple Intracranial Aneurysms

Willoughby

1984

Anaesth Intensive Care

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Pregnancy should not greatly alter the anaesthetic management of a patient with intracranial aneurysms. Controlled hypotension is the method of choice for meeting surgical requirements. 9,10 Primary attention to the mother with judicious use of sodium nitroprusside is unlikely to compromise the foetus. 6,8,11,26 Sodium nitroprusside is not teratogenic in animal experiments. 25 At present, the biochemical consequences for the foetus of prolonged nitrous oxide anaesthesia are not clear. Present data would support folinic acid administration. 68,70

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Section: Snp In Pregnancymentioning

confidence: 87%

“…9,10 Primary attention to the mother with judicious use of sodium nitroprusside is unlikely to compromise the foetus. 6,8,11,26 Sodium nitroprusside is not teratogenic in animal experiments. 25 At present, the biochemical consequences for the foetus of prolonged nitrous oxide anaesthesia are not clear.…”

mentioning

confidence: 97%

Sodium Nitroprusside, Pregnancy and Multiple Intracranial Aneurysms

Willoughby

1984

Anaesth Intensive Care

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“…26 The results from animal studies support the idea that SNP use for hypertensive emergencies deserves reappraisal and its use during general endotracheal anesthesia merits further investigation. 27 Almost all publications on SNP mention the possible fetal risk due to cyanide toxicity, which was initially demonstrated in animal studies. One of these studies, which was designed to determine the maternal and fetal hemodynamic effects of SNP in normal and hypertensive animal models, 28 demonstrated that the drug crosses the placenta and that the fetal concentration of cyanide is related to maternal SNP levels.…”

Section: Discussionmentioning

confidence: 99%

Does sodium nitroprusside kill babies? A systematic review

et al. 2007

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“…If it is possible to proceed to caesarian section then this is preferable as soon as the mother is stable and the baby is prepared. This may be possible in four to six hours from the initial emergency or may be delayed for foetal reasons for [24][25][26][27][28][29][30][31][32][33][34][35][36] hours. Tables 3-6.…”

Section: Clinical Management Of the Patient With Severe Gestosismentioning

confidence: 99%

“…I believe that the experimental foetal deaths in the study by Naulty and colleagues 21 may have been due to acidemia and placental ischaemia. There are other reports of successful usage of SNP in treatment of severe hypertension in pregnant ewes 24 and in humans. 6 The present series of patients now adds to this success with short-term use of SNP.…”

Section: Cnsmentioning

confidence: 99%

Management of Severe Pregnancy-Induced Hypertension, or Gestosis, with Sodium Nitroprusside

1990

Anaesth Intensive Care

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Eclampsia continues to be a serious complication of pregnancy with deaths reported by Maternal Mortality Committees.! The approximate incidence of eclampsia and the factors associated with this syndrome are listed in Table 1. Preeclampsia with high blood pressure, increased reflexes, clonus and headache is an equally serious complication because this condition frequently leads on to eclampsia. The management of these serious conditions has been controversial for many years. The main approach to therapy has been the emphasis on lowering of the blood pressure. This approach ignores the other manifestations of the disease such as thrombocytopenia, oedema, proteinuria and oliguria, hypovolaemia and often other major organ imbalance induced by the disease. Table 2 lists the maternal organ dysfunction which may accompany this pregnancy disorder. The current name for this condition is Pregnancy-Induced Hypertension (PIH) which has tended to replace Pre-eclampsia or Pre-eclamptic Toxaemia (PET). This name of PIH does not effectively describe the problem• because hypertension may be absent, or only minor, and probably is reactive rather than causative. Goodlin 2 has recommended the term Gestosis for this pregnancy complication and this has some merit as the fundamental problem would appear to be the imbalance between prostacyclin (or PGI 2) and thromboxane A2 (TXA f) such that in the more severe forms of the conditIOn TXA 2 : PGI 2 ratios are 8: 1 rather than the more normal 1: 1. 3 The aetiology of this abnormality would appear to be associated with placental implantation, and there

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Fetal and Maternal Effects of Sodium Nitroprusside Used to Counteract Hypertension in Gravid Ewes

Cited by 5 publications

References 0 publications

Sodium Nitroprusside, Pregnancy and Multiple Intracranial Aneurysms

Sodium Nitroprusside, Pregnancy and Multiple Intracranial Aneurysms

Does sodium nitroprusside kill babies? A systematic review

Management of Severe Pregnancy-Induced Hypertension, or Gestosis, with Sodium Nitroprusside

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