Fetal and Infant Spontaneous General Movements as Predictors of Developmental Disabilities

Zuk, Luba

doi:10.1002/ddrr.1104

Cited by 28 publications

(37 citation statements)

References 77 publications

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“…Perinatal assessment of GMs is a reflection of the integrity of nervous system (37). Fetal and infant GMs might provide useful information for predicting neurodevelopmental disabilities (38). This study found that of the 10 fetal movement patterns, GM was the only one movement pattern whose frequency was positively related to gestational age (11-14 week).…”

Section: Discussionmentioning

confidence: 99%

Visualization and quantitation of fetal movements by real-time three-dimensional ultrasound with live xPlane imaging in the first trimester of pregnancy

Tang

Luo

et al. 2016

Croat Med J

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AimTo prove whether real-time three-dimensional (3D) ultrasound with live xPlane imaging is better in observing fetal movements than standard ultrasound imaging.Methods50 healthy women with singleton pregnancies (22-43 years old) at 11 to 14 weeks of gestation underwent real-time 3D ultrasound examination with live xPlane imaging from July 2014 to February 2015. The incidence and frequency of 10 fetal movement patterns in 10 minutes were evaluated, including general movements (GMs), isolated arm movements, isolated leg movements, hiccup, stretching, breathing, startle, jaw opening, isolated head retroflexion, and isolated head anteflexion. The correlation between gestational age and frequency of each fetal movement pattern was analyzed.ResultsGM had the highest incidence (100%), followed by startle (84%) and isolated arm movements (68%). Their median frequency was 5 (IQR 3-6), 5 (IQR 1.75-11.5), and 1 (IQR 0-2), respectively. GM (Z = 5.875, P < 0.001) and startle (Z = 5.302, P < 0.001) had significantly higher frequency than isolated arm movements. The other 7 fetal movement patterns had much lower incidence and frequency. The frequency of GM was positively correlated with gestational age (r = 0.360, P = 0.010).ConclusionReal-time 3D ultrasound with live x Plane imaging was shown to be a feasible tool for observing fetal movements.

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Section: Discussionmentioning

confidence: 99%

Visualization and quantitation of fetal movements by real-time three-dimensional ultrasound with live xPlane imaging in the first trimester of pregnancy

Tang

Luo

et al. 2016

Croat Med J

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“…The voluntary movement gradually supersedes general movement after 3 months of age, which corresponds with the decrease of the SP layer, suggesting that general movement is a reflection of spontaneous activity in early-born neurons including SpNs (Bayatti et al, 2008;Hadders-Algra, 2018). Many studies have reported that observation of general movement could be useful to predict developmental delay or autism that may occur at later ages (Zuk, 2011;Kanemaru et al, 2013;So et al, 2016;Gima et al, 2018). Moreover, the finding that genes expressed in a subplate-specific manner in mice are significantly associated with autism spectrum disorders and schizophrenia supports the notion that general movement in fetuses and neonatal human babies is a reflection of the spontaneous activity of SpNs.…”

Section: Subplate Function and Brain Developmental Disordersmentioning

confidence: 99%

Subplate Neurons as an Organizer of Mammalian Neocortical Development

Ohtaka-Maruyama

2020

Front. Neuroanat.

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Subplate neurons (SpNs) are one of the earliest born and matured neurons in the developing cerebral cortex and play an important role in the early development of the neocortex. It has been known that SpNs have an essential role in thalamocortical axon (TCA) pathfinding and the establishment of the first neural circuit from the thalamus towards cortical layer IV. In addition to this function, it has recently been revealed in mouse corticogenesis that SpNs play an important role in the regulation of radial neuronal migration during the mid-embryonic stage. Moreover, accumulating studies throw light on the possible roles of SpNs in adult brain functions and also their involvement in psychiatric or other neurological disorders. As SpNs are unique to mammals, they may have contributed to the evolution of the mammalian neocortex by efficiently organizing cortical formation during the limited embryonic period of corticogenesis. By increasing our knowledge of the functions of SpNs, we will clarify how SpNs act as an organizer of mammalian neocortical formation.

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“…These behaviors individually have been shown to be important for early learning and development and to relate to future neuromotor and cognitive outcome. 22,29,31 However, what is even more interesting and important for clinicians is to recognize that these behaviors are highly interrelated and impact one another dynamically in early development. 16,80 Thus intervention to address future developing skills such as object manipulation skills should not wait until infants are older or have begun to show delayed performance of these skills.…”

Section: 0 Conclusionmentioning

confidence: 99%

Characterization and intervention for upper extremity exploration & reaching behaviors in infancy

Lobo

Galloway

Heathcock

2015

Journal of Hand Therapy

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The purpose of this article is to: 1) highlight general exploration, reaching, and object exploration behaviors as key activities of daily living in infancy, 2) describe how knowledge of early warning signs for these behaviors may improve early assessment, and 3) discuss interventions that may advance performance of these behaviors. Early intervention for at-risk infants and their families should focus on improving performance of these behaviors for several reasons. First, these early, interrelated upper extremity behaviors serve an integral role in global learning and development in infancy. Second, among at-risk populations, differences have been observed in the quantity and quality of performance of these behaviors. In many cases, these differences are in turn associated with additional perceptual-motor and cognitive delays. This article fills a gap in the literature by summarizing how early assessment and intervention can target these key early behaviors in populations at risk for upper extremity disabilities, such as those born preterm, with Down syndrome, brachial plexus palsy, or arthrogryposis multiplex congentia.

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Fetal and Infant Spontaneous General Movements as Predictors of Developmental Disabilities

Cited by 28 publications

References 77 publications

Visualization and quantitation of fetal movements by real-time three-dimensional ultrasound with live xPlane imaging in the first trimester of pregnancy

Visualization and quantitation of fetal movements by real-time three-dimensional ultrasound with live xPlane imaging in the first trimester of pregnancy

Subplate Neurons as an Organizer of Mammalian Neocortical Development

Characterization and intervention for upper extremity exploration & reaching behaviors in infancy

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