Fetal and Infant Growth Patterns and Risk of Lower Lung Function and Asthma. The Generation R Study

Abstract

Both restricted fetal weight growth, partly depending on infant weight growth, and accelerated fetal and infant weight growth predispose children to lower lung function and a potential risk for respiratory diseases later in life.

Infant growth and childhood respiratory health: how long is the road to preventive measures?

“…Previous studies were consistent in observing an increased risk of wheeze and asthma in relationship with early weight growth, both in preschoolers and in school-aged children 4 6 7 10–13. The lack of association with school-age asthma has been reported by one study conducted in the same population of children from the Generation R cohort,9 while in the same children an association with preschool wheezing and asthma has been reported 7 15. Despite the careful definition that combined self-reported physician-diagnosed asthma with either wheezing or inhalant medication use in the past 12 months, the outcome misclassification cannot be completely ruled out.…”

The influence of Epstein‐Barr virus and cytomegalovirus on childhood respiratory health: A population‐based prospective cohort study

“…Children (n = 239) with a >5%, instead of ≤5%, deviation in FEV 1 and FVC, and at least one blow with adequate reach and duration of plateau according to ATS/ERS criteria were also included. The effect estimates for the associations did not differ when we in‐ or excluded those children . Information on asthma medication use in the past 12 months was obtained during the research centre visit.…”

“…The effect estimates for the associations did not differ when we inor excluded those children. 20,21 Information on asthma medication use in the past 12 months was obtained during the research centre visit. Asthma was defined as ever diagnosis of asthma, obtained by questionnaire at the age 10 years, with either wheezing or asthma medication use in the past 12 months.…”

Pediatric Pulmonology year in review 2017: Part 3

“…3,4 The link between childhood growth patterns and asthma risk continues to be a topic of study. 5,6 A meta-analysis demonstrated as relationship between body mass index (BMI) z-score and exerciseinduced bronchoconstriction (EIB) risk in asthmatic children. 7 A BMI zscore of 0.5-1.5 increased EIB 2.9 times in girls, and 4.4 times in boys, respectively, compared to asthmatic children with a BMI z-score of −0.5 to 0.5.…”

“…Extremely interesting concepts are emerging regarding the complex relationships among early life exposures, microbial dysbiosis, metabolic dysfunction, and the risk for development of atopy and asthma in children . The link between childhood growth patterns and asthma risk continues to be a topic of study . A meta‐analysis demonstrated as relationship between body mass index (BMI) z ‐score and exercise‐induced bronchoconstriction (EIB) risk in asthmatic children .…”