Fetal alcohol exposure impairs learning and memory functions and elevates levels of various biochemical markers of Alzheimer's disease in the brain of 12‐month‐old rats

Abstract

Alzheimer's disease, a neurodegenerative disease, is observed mostly in elderly individuals. It is characterized by irreversible damage to thought, memory, speech, and progressive cognitive impairment (Goedert et al, 2006;Ravi & Reddy, 2017). It is generally believed that a rapid degeneration of cholinergic neurons may be a significant contributor to memory loss in Alzheimer's patients (Bartus et al., 1982). Alzheimer's disease often causes the appearance of senile plaques, which are believed to be developed due to the deposition of extracellular β-amyloid (Aβ) in cortical and limbic areas of the human