Fetal abnormalities leading to termination of singleton pregnancy: the 7‐year experience of a single medical center

Vaknin, Zvi; Ben‐Ami, Ido; Reish, Orit; Herman, Arie; Maymon, Ron

doi:10.1002/pd.1531

Cited by 35 publications

(49 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reason for this rise may be the growing use of echocardiogram as a complementary scan, as well as the increasing experience of fetal heart screening among the obstetricians in Turkey. In our series, the most common chromosomal anomaly was trisomy 21, which was consistent with the other studies (4,7,8).…”

Section: Discussionsupporting

confidence: 82%

“…Central nervous system anomalies accounted for more than half of the indications for both early and late terminations. This finding is consistent with the studies which showed that central nervous system malformations are the most common structural malformations leading to the TOP (4,7,8,12,13). Fetal autopsy has a particularly valuable role in the counseling of families after the TOP (14).…”

Section: Discussionsupporting

confidence: 81%

“…In spite of the improvement in screening and detection of chromosomal anomalies in Turkey, the overall proportion of TOP due to chromosomal anomalies in our study (9.4%) was still lower than that in the previous studies (30-39%) (4,7,8). The reason for this low rate might be the religious and cultural factors which lead fewer couples to accept karyotype analysis or termination in comparison to the couples in Western countries.…”

Section: Discussioncontrasting

confidence: 54%

See 2 more Smart Citations

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Çorbacıoğlu¹,

Aslan²,

Aydın³

et al. 2012

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Objective:We reviewed the data of the termination of pregnancy (TOP) cases between 2002 and 2010 to evaluate the changes in fetal indications for both early and late TOPs in this period. Material and Methods:The data of 962 TOP cases were analysed in two groups according to the periods as in 2002-2006 and 2007-2010. The women were also subdivided into two categories according to their gestational age; <23 weeks' gestation (early termination) and ≥23 weeks' gestation (late termination).Results: Four hundred and fifty-eight (47.6%) of TOPs were performed between 2002 and 2006 (Group 1) and 504 (52.3%) were performed between 2007 and 2010 (Group 2). The number of early (<23 weeks) and late (≥23 weeks) terminations were 583 (60.6%) and 379 (39.3%), respectively. The vast majority of anomalies were central nervous sytem malformations (51.8%). They were followed by multiple anomalies (10.2%) and chromosomal anomalies (9.4%). Chromosomal and cardiovascular system anomalies were significantly higher in 2007-2010 in comparison to 2002-2006 (p<0.0001 and p=0.002, respectively). There was no statistically significant difference between the fetal indications that led to early termination compared to those that led to late termination. Conclusion:The distribution of indications for TOP was influenced by the development in prenatal screening policy, resulting in a significant increase in terminations due to chromosomal and cardiovascular system anomalies. Cultural, educational, religious and legal factors cause differences in the indications for TOP as well as the gestational age that TOPS are performed. Sonuç: Terminasyon endikasyonlarının dağılımı prenatal tarama politikalarındaki gelişimden etkilenmiş, buna bağlı olarak kromozom ve kardiyovaskuler sistem anomalileri nedeniyle yapılan terminasyonların sayısı önemli ölçüde artmıştır. Kültürel, eğitimsel, dini ve yasal faktörler terminasyon yapıldığı gebelik haftasının yanı sıra terminasyon endikasyonlarında da değişikliklere yol açmaktadır. (J Turkish-German Gynecol Assoc 2012; 13: 85-90)

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 54%

See 1 more Smart Citation

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Çorbacıoğlu¹,

Aslan²,

Aydın³

et al. 2012

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

show abstract

“…Erken terminasyonların aksine geç terminasyonların en sık nedeni, fetal yapısal anomaliler olup, bunlar içinde en sık görülen fetal yapısal anomaliler MSS anomalileridir (9,11,14,15,16) . Hidrosefali, korpus kallosum agenezisi ve lizensefali gibi genellikle ikinci ve erken üçüncü trimesterde belirgin hâle gelen MSS anomalilerinin geç terminasyonlardaki sıklığı daha fazladır (11) .…”

Section: Discussionunclassified

Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Tayyar¹,

Açar²,

Turhan³

et al. 2017

IKSST

View full text Add to dashboard Cite

show abstract

“…The malformations constitute the most frequent indication for termination of pregnancy. This group include different pathologies in which skeletal system is a small percentage variable between 6% and 16% [30][31][32]. Although most of the TA referred to our laboratory came from private centre with no medical or anatomic record, we have diagnosed 30% of TA (5 skeletal dysplasias and 1 triploidy) from 20 cases.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

Trujillo-Tiebas

Fenollar-Cortés

Lorda‐Sánchez

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Prenatal diagnosis with ultrasound findings compatible with skeletal dysplasia due to FGFR3 mutations over a 9 year period in pregnancies and abortuses. Methods 54 samples were studied. Aneuploidy studies were carried out on all samples. By sequencing analysis, we determined mutations for achondroplasia (ACH), hypochondroplasia (HCH), and type I and type II tanathophoric dysplasia (TD). Results 2 chorionic villi samples had a G380R mutation due to a mother with ACH; 4 amniotic fluid samples with TDs in which the foetuses had micromelia plus hypoplastic thoraces; 5 samples from abortuses with TDs. Neither ACH nor HCH occurred in sporadic cases. Conclusions Molecular studies in ongoing pregnancies are indicated in cases with an affected parent, a family history with positive molecular studies (maternal anxiety), and when the US finding demonstrates micromelia with a hypoplastic thorax. A protocol for tissues of abortuses should include an X-ray, pathologic anatomy, and genetic studies.

show abstract

Fetal abnormalities leading to termination of singleton pregnancy: the 7‐year experience of a single medical center

Abstract: The impact of early chromosomal/genetic screening contributes to early TOPs, while midgestation anomaly and cardiac scanning significantly contribute to late TOPs. Fetal infection contributes equally to both categories of TOPs.

Cited by 35 publications

References 14 publications

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Late termination of pregnancy due to fetal abnormalities: An analysis of 229 cases

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

Contact Info

Product

Resources

About