Ferumoxytol-enhanced ultrashort TE MRA and quantitative morphometry of the human kidney vasculature

Timms, Liam; Zhou, Tianyi; Lyu, Yue; Qiao, Junfei; Mishra, Vishala; Lahoud, Rita Maria; Jayaraman, Gayatri Veeramani; Allegretti, Andrew S.; Drew, David A.; Seethamraju, Ravi; Harisinghani, Mukesh G.; Sridhar, Srinivas

doi:10.1007/s00261-021-02984-2

Cited by 4 publications

(6 citation statements)

References 44 publications

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“…Zamecnik et al 71 showed excellent image quality and visibility of pelvic arteries using ferumoxtran-10-enhanced 3T MRA. Timms et al 72 optimised their QUTE-CE MRI for the view of kidney vasculature, yielding great detail of renal anatomy or renal cysts and enabling quantitative morphometric analysis of abdominal and renal vessels.…”

Section: Next-generation Magnetic Nanoparticles In Mri: Translating R...mentioning

confidence: 99%

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials

Lapusan,

Borlan,

Focsan

2024

Nanoscale Adv.

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Section: Next-generation Magnetic Nanoparticles In Mri: Translating R...mentioning

confidence: 99%

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials

Lapusan,

Borlan,

Focsan

2024

Nanoscale Adv.

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“…Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) was infused, under observation, external to the MR scanner with a total 510 mg dose of elemental iron in 11 participants and 3 mg/kg of body weight in 4 participants. A subset of 5 participants also underwent abdominal scans [14].…”

Section: Study Cohortmentioning

confidence: 99%

“…Second, this study did not capture first-pass images during the arterial phase of ferumoxytol as our participants were infused externally to the MRI scanner due to logistic constraints. Separation of arteries and veins is possible with first-pass imaging during contrast infusion and is now used with QUTE-CE MRA in an ongoing study [14]. Artery-vein segmentation may also be achieved in postprocessing, as shown successfully in CT angiography [32].…”

Section: 1mentioning

confidence: 99%

Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI

Timms,

Zhou,

Qiao

et al. 2024

International Journal of Biomedical Imaging

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Background. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. Optimization of protocols for ferumoxytol deployment is necessary to realize its potential. Methods. We present first-in-human clinical results of the Quantitative Ultrashort Time-to-Echo Contrast Enhanced (QUTE-CE) MRA technique using the superparamagnetic iron oxide nanoparticle agent ferumoxytol for vascular imaging of the head/brain in 15 subjects at 3.0T. The QUTE-CE MRA method was implemented on a 3T scanner using a stack-of-spirals 3D Ultrashort Time-to-Echo sequence. Time-of-flight MRA and standard TE T1-weighted (T1w) images were also collected. For comparison, gadolinium-enhanced blood pool phase images were obtained retrospectively from clinical practice. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and intraluminal signal heterogeneity (ISH) were assessed and compared across approaches with Welch’s two-sided t-test. Results. Fifteen volunteers (54±17 years old, 9 women) participated. QUTE-CE MRA provided high-contrast snapshots of the arterial and venous networks with lower intraluminal heterogeneity. QUTE-CE demonstrated significantly higher SNR (1707±226), blood-tissue CNR (1447±189), and lower ISH (0.091±0.031) compared to ferumoxytol T1-weighted (551±171; 319±144; 0.186±0.066, respectively) and time-of-flight (343±104; 269±82; 0.190±0.016, respectively), with p<0.001 in each comparison. The high CNR increased the depth of vessel visualization. Vessel lumina were captured with lower heterogeneity. Conclusion. Quantitative Ultrashort Time-to-Echo Contrast-Enhanced MR angiography provides approximately 5-fold superior contrast with fewer artifacts compared to other contrast-enhanced vascular imaging techniques using ferumoxytol or gadolinium, and to noncontrast time-of-flight MR angiography, for clinical vascular imaging. This trial is registered with NCT03266848.

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“…Optical clearing and lightsheet microscopy have been used to quantify portions of the human kidney vascular network [21] however, it has not yet been possible to capture the intact vascular network of the human kidney without physical sectioning the tissue, beyond approximately six vessel divisions [22]. MRI has been used to quantify larger vessels both in vivo and post mortem [23], [24], but lacks the resolution capable of imaging small vessels and arterioles [23].…”

Section: Introductionmentioning

confidence: 99%

“…Due to these limitations, human kidney vascular network analysis is often predominantly focused on the very large, first three branches of the arterial tree [23],…”

Section: Introductionmentioning

confidence: 99%

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

Rahmani

Jafree

Lee

et al. 2023

Preprint

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Background: The kidney vasculature is exquisitely structured to orchestrate renal function. Structural profiling of the vasculature in intact rodent kidneys, has provided insights into renal haemodynamics and oxygenation, but has never been extended to the human kidney beyond a few vascular generations. We hypothesised that synchrotron-based imaging of a human kidney would enable assessment of vasculature across the whole organ. Methods: An intact kidney from a 63-year-old male was scanned using hierarchical phase-contrast tomography (HiP-CT), followed by semi-automated vessel segmentation and quantitative analysis. These data were compared to published micro-CT data of whole rat kidney. Results: The intact human kidney vascular network was imaged with HiP-CT at 25 μm voxels, representing a 20-fold increase in resolution compared to clinical CT scanners. Our comparative quantitative analysis revealed the number of vessel generations, vascular asymmetry and a structural organisation optimised for minimal resistance to flow, are conserved between species, whereas the normalised radii are not. We further demonstrate regional heterogeneity in vessel geometry between renal cortex, medulla, and hilum, showing how the distance between vessels provides a structural basis for renal oxygenation and hypoxia. Conclusions: Through the application of HiP-CT, we have provided the first quantification of the human renal arterial network, with a resolution comparable to that of light microscopy yet at a scale several orders of magnitude larger than that of a renal punch biopsy. Our findings bridge anatomical scales, profiling blood vessels across the intact human kidney, with implications for renal physiology, biophysical modelling, and tissue engineering.

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Ferumoxytol-enhanced ultrashort TE MRA and quantitative morphometry of the human kidney vasculature

Cited by 4 publications

References 44 publications

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials

Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

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