Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings

Kliewer, Mark A.; Bockoven, Crystal; Reeder, Scott B.; Bagley, Anjuli R; Sadowski, Elizabeth A.; Iruretagoyena, J. Igor; Beninati, Michael; Fritsch, Michael K.

doi:10.1016/j.placenta.2023.02.003

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the R&D level of intelligent networked vehicles in China is still focused on the automatic driving of SAE3 and below, the construction of special test platform must follow the principle of "two steps" in terms of speed and practicality. According to the mature experience of establishing an intelligent test site for interconnected vehicles abroad, from the perspective of test environment and test facilities, the following suggestions are put forward for building an intelligent test site for interconnected vehicles in China [11].…”

Section: Suggestions On the Construction Of Domestic Intelligent Netw...mentioning

confidence: 99%

Research on Planning Scheme Evaluation and Scene Module Analysis of Intelligent Networked Automobile Proving Ground

2023

uts

View full text Add to dashboard Cite

The development of Internet and artificial intelligence technology endows the traditional automobile industry with the color of intelligent and networked industry. The development of intelligent networked vehicles can improve the related transportation efficiency and solve the existing disadvantages such as environmental damage and energy depletion. As a testing ground for evaluating and verifying the quality and performance of vehicles, it will be the focus of its support system development. Therefore, this project has considerable practical application value. Based on the experience of planning and construction at home and abroad, this paper analyzes the comparison method of multi-scheme selection of overall planning, functional layout and road layout, estimates the cost and realizes the scheme evaluation of intelligent networked automobile proving ground. At the same time, the key points of scene design module are studied to provide reasonable design methods for its construction and implementation, and provide technical reference for the design of related fields.

show abstract

Section: Suggestions On the Construction Of Domestic Intelligent Netw...mentioning

confidence: 99%

Research on Planning Scheme Evaluation and Scene Module Analysis of Intelligent Networked Automobile Proving Ground

2023

uts

View full text Add to dashboard Cite

show abstract

“…Ferumoxytol has been used off-label as a contrast agent for vascular imaging, perfusion imaging, and other applications [17]. Multiple sites have begun studies to determine the efficacy of this technique for diagnosing PAS and other placental disorders [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study of Ferumoxtyol for Contrast-enhanced MRI of Retroplacental Clear Space Disruption in Placenta Accreta Spectrum (PAS)

Badachhape

Burnett

Bhandari

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: Placenta accreta spectrum (PAS) occurs when the placenta is pathologically adherent to the myometrium. An intact retroplacental clear space (RPCS) is a marker of normal placentation, but visualization with conventional imaging techniques is a challenge. In this study, we investigate use of an FDA-approved iron oxide nanoparticle, ferumoxytol, for contrast-enhanced magnetic resonance imaging of the RPCS in mouse models of normal pregnancy and PAS. We then demonstrate the translational potential of this technique in human patients presenting with severe PAS (FIGO Grade 3C), moderate PAS (FIGO Grade 1), and no PAS. Methods: A T1-weighted gradient recalled echo (GRE) sequence was used to determine the optimal dose of ferumoxytol in pregnant mice. Pregnant Gab3-/- mice, which demonstrate placental invasion, were then imaged at day 16 of gestation alongside wild-type (WT) pregnant mice which do not demonstrate invasion. Signal-to-noise ratio (SNR) was computed for placenta and RPCS for all fetoplacental units (FPUs) with ferumoxytol-enhanced magnetic resonance imaging (Fe-MRI) and used for the determination of contrast-to-noise ratio (CNR). Fe-MRI was also performed in 3 pregnant subjects using standard T1 and T2 weighted sequences and a 3D magnetic resonance angiography (MRA) sequence. RPCS volume and relative signal were calculated in all three subjects. Results: Ferumoxytol administered at 5 mg/kg produced strong T1 shortening in blood and led to strong placental enhancement in Fe-MRI images. Gab3-/- mice demonstrated loss of hypointense region characteristic of the RPCS relative to WT mice in T1w Fe-MRI. CNR between RPCS and placenta was lower in FPUs of Gab3-/- mice compared to WT mice, indicating higher degrees of vascularization and interruptions throughout the space. In human patients, Fe-MRI at a dose of 5 mg/kg enabled high uteroplacental vasculature signal and quantification of the volume and signal profile in severe and moderate invasion of the placenta relative to a non-PAS case. Discussion: Ferumoxytol, an FDA-approved iron oxide nanoparticle formulation, enabled visualization of abnormal vascularization and loss of uteroplacental interface in a murine model of PAS. The potential of this non-invasive visualization technique was then further demonstrated in human subjects. Diagnosis of placental invasion using Fe-MRI may provide a sensitive method for clinical detection of PAS.

show abstract

Cotyledon‐Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast‐Enhanced MRI

Chen,

Seiter,

Keding

et al. 2024

Magnetic Resonance Imaging

View full text Add to dashboard Cite

BackgroundRecently, dynamic contrast‐enhanced (DCE) MRI with ferumoxytol as contrast agent has recently been introduced for the noninvasive assessment of placental structure and function throughout. However, it has not been demonstrated under pathological conditions.PurposeTo measure cotyledon‐specific rhesus macaque maternal placental blood flow using ferumoxytol DCE MRI in a novel animal model for local placental injury.Study TypeProspective animal model.SubjectsPlacental injections of Tisseel (three with 0.5 mL and two with 1.5 mL), monocyte chemoattractant protein 1 (three with 100 μg), and three with saline as controls were performed in a total of 11 rhesus macaque pregnancies at approximate gestational day (GD 101). DCE MRI scans were performed prior (GD 100) and after (GD 115 and GD 145) the injection (term = GD 165).Field Strength/Sequence3 T, T1‐weighted spoiled gradient echo sequence (product sequence, DISCO).AssessmentSource images were inspected for motion artefacts from the mother or fetus. Placenta segmentation and DCE processing were performed for the dynamic image series to measure cotyledon specific volume, flow, and normalized flow. Overall placental histopathology was conducted for controls, Tisseel, and MCP‐1 animals and regions of tissue infarctions and necrosis were documented. Visual inspections for potential necrotic tissue were conducted for the two Tisseelx3 animals.Statistical TestsWilcoxon rank sum test, significance level P < 0.05.ResultsNo motion artefacts were observed. For the group treated with 1.5 mL of Tisseel, significantly lower cotyledon volume, flow, and normalized flow per cotyledon were observed for the third gestational time point of imaging (day ~145), with mean normalized flow of 0.53 minute−1. Preliminary histopathological analysis shows areas of tissue necrosis from a selected cotyledon in one Tisseel‐treated (single dose) animal and both Tisseelx3 (triple dose) animals.Data ConclusionThis study demonstrates the feasibility of cotyledon‐specific functional analysis at multiple gestational time points and injury detection in a placental rhesus macaque model through ferumoxytol‐enhanced DCE MRI.Level of EvidenceNATechnical EfficacyStage 2

show abstract

Ferumoxytol-enhanced MR demonstration of changes to internal placental structure in placenta accreta spectrum: Preliminary findings

Cited by 3 publications

References 33 publications

Research on Planning Scheme Evaluation and Scene Module Analysis of Intelligent Networked Automobile Proving Ground

Research on Planning Scheme Evaluation and Scene Module Analysis of Intelligent Networked Automobile Proving Ground

Feasibility Study of Ferumoxtyol for Contrast-enhanced MRI of Retroplacental Clear Space Disruption in Placenta Accreta Spectrum (PAS)

Cotyledon‐Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast‐Enhanced MRI

Contact Info

Product

Resources

About