Ferumoxytol enhanced black-blood cardiovascular magnetic resonance imaging

Nguyen, Kim‐Lien; Park, Eun Ah; Yoshida, Takegawa; Hu, Peng; Finn, J. Paul

doi:10.1186/s12968-017-0422-y

Cited by 13 publications

(15 citation statements)

References 34 publications

(33 reference statements)

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“…It may also enable applications well beyond those possible with GBCAs (5,6). Since its clinical introduction in 2009, ferumoxytol has affected the practice of MRI at academic centers to fill a variety of unmet clinical needs when used off label (8)(9)(10)(11)(12)(13).…”

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confidence: 99%

“…The FDA identified bolus injection of undiluted ferumoxytol as a potential risk factor and issued updated therapeutic prescription recommendations that included dilution, infusion over 15 minutes (originally over 17 seconds), and hemodynamic monitoring for up to 30 minutes after infusion. Despite studies supporting innovative off-label theranostic applications (5,6,(8)(9)(10)(11)(12)(13) and single-center reports on safety (15)(16)(17)(18)(19), the relative safety of ferumoxytol for diagnostic use is still not well defined. Thus, we established the FeraSafe multicenter MRI registry (https:// ferasafe.ucla.edu) as an academic collaboration to investigate the safety of ferumoxytol and to facilitate collaboration among users exploring its diagnostic applications.…”

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confidence: 99%

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Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI

et al. 2019

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I n the 30 years since gadolinium-based contrast agents (GBCAs) were first introduced to enhance MRI (1), their adoption into routine clinical practice has been prolific. Worldwide, more than 450 million doses of GBCAs have been administered and have yielded indispensable diagnostic information in virtually every organ system (2). The safety profile of GBCAs was relatively unblemished until their association with nephrogenic systemic fibrosis in 2006 (3). Clinical practice patterns were altered rapidly, and judicious use or avoidance of GBCAs in patients with

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Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI

et al. 2019

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“…Improved coronary conspicuity may also be achieved by disabling the fat suppression pulse which could yield high contrast between the epicardial fat embedding the coronary arteries and the suppressed signal from the coronary lumen. Recently, an intrasvascular iron-based contrast agent, ferumoxytol, has been demonstrated to improve blood suppression for 2D black-blood FSE [ 45 ]. A similar approach may prove beneficial to improve blood suppression for 3D FSE as well, due to the significantly shortened T2 of the blood pool.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of 3D black-blood variable refocusing angle fast spin echo cardiovascular magnetic resonance for visualization of the whole heart and great vessels in congenital heart disease

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Dyer

et al. 2018

Journal of Cardiovascular Magnetic Resonance

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BackgroundVolumetric black-blood cardiovascular magnetic resonance (CMR) has been hampered by long scan times and flow sensitivity. The purpose of this study was to assess the feasibility of black-blood, electrocardiogram (ECG)-triggered and respiratory-navigated 3D fast spin echo (3D FSE) for the visualization of the whole heart and great vessels.MethodsThe implemented 3D FSE technique used slice-selective excitation and non-selective refocusing pulses with variable flip angles to achieve constant echo signal for tissue with T1 (880 ms) and T2 (40 ms) similar to the vessel wall. Ten healthy subjects and 21 patients with congenital heart disease (CHD) underwent 3D FSE and conventional 3D balanced steady-state free precession (bSSFP). The sequences were compared in terms of ability to perform segmental assessment, local signal-to-noise ratio (SNRl) and local contrast-to-noise ratio (CNRl).ResultsIn both healthy subjects and patients with CHD, 3D FSE showed superior pulmonary vein but inferior coronary artery origin visualisation compared to 3D bSFFP. However, in patients with CHD the combination of 3D bSSFP and 3D FSE whole-heart imaging improves the success rate of cardiac morphological diagnosis to 100% compared to either technique in isolation (3D FSE, 23.8% success rate, 3D bSSFP, 5% success rate). In the healthy subjects SNRl for 3D bSSFP was greater than for 3D FSE (30.1 ± 7.3 vs 20.9 ± 5.3; P = 0.002) whereas the CNRl was comparable (17.3 ± 5.6 vs 17.4 ± 4.9; P = 0.91) between the two scans.ConclusionsThe feasibility of 3D FSE for whole-heart black-blood CMR imaging has been demonstrated. Due to their high success rate for segmental assessment, the combination of 3D bSSFP and 3D FSE may be an attractive alternative to gadolinium contrast enhanced morphological CMR in patients with CHD.Electronic supplementary materialThe online version of this article (10.1186/s12968-018-0508-1) contains supplementary material, which is available to authorized users.

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“…CMR is more than “cardiac,” and JCMR welcomes submissions in the vascular arena. 2017 publications included studies imaging intravascular thrombus [106], vascular calcification [107], iron oxide vascular imaging [108], aortic imaging [109, 110], vascular wall imaging [111, 112] as well novel imaging methods such as quiescent-interval slice-selective (QISS) imaging [113].…”

Section: Vascular Imagingmentioning

confidence: 99%

Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review

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2019

Journal of Cardiovascular Magnetic Resonance

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There were 89 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2017, including 76 original research papers, 4 reviews, 5 technical notes, 1 guideline, and 3 corrections. The volume was down slightly from 2017 with a corresponding 15% decrease in manuscript submissions from 405 to 346 and thus reflects a slight increase in the acceptance rate from 25 to 26%. The decrease in submissions for the year followed the initiation of the increased author processing charge (APC) for Society for Cardiovascular Magnetic Resonance (SCMR) members for manuscripts submitted after June 30, 2018. The quality of the submissions continues to be high. The 2018 JCMR Impact Factor (which is published in June 2019) was slightly lower at 5.1 (vs. 5.46 for 2017; as published in June 2018. The 2018 impact factor means that on average, each JCMR published in 2016 and 2017 was cited 5.1 times in 2018. Our 5 year impact factor was 5.82.In accordance with Open-Access publishing guidelines of BMC, the JCMR articles are published on-line in a continuus fashion in the chronologic order of acceptance, with no collating of the articles into sections or special thematic issues. For this reason, over the years, the Editors have felt that it is useful for the JCMR audience to annually summarize the publications into broad areas of interest or themes, so that readers can view areas of interest in a single article in relation to each other and contemporaneous JCMR publications. In this publication, the manuscripts are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought within the journal. In addition, as in the past two years, I have used this publication to also convey information regarding the editorial process and as a “State of our JCMR.”This is the 12th year of JCMR as an open-access publication with BMC (formerly known as Biomed Central). The timing of the JCMR transition to the open access platform was “ahead of the curve” and a tribute to the vision of Dr. Matthias Friedrich, the SCMR Publications Committee Chair and Dr. Dudley Pennell, the JCMR editor-in-chief at the time. The open-access system has dramatically increased the reading and citation of JCMR publications and I hope that you, our authors, will continue to send your very best, high quality manuscripts to JCMR for consideration. It takes a village to run a journal and I thank our very dedicated Associate Editors, Guest Editors, Reviewers for their efforts to ensure that the review process occurs in a timely and responsible manner. These efforts have allowed the JCMR to continue as the premier journal of our field. This entire process would also not be possible without the dedication and efforts of our managing editor, Diana Gethers. Finally, I thank you for entrusting me with the editorship of the JCMR as I begin my 4th year as your editor-in-chief. It has been a tremendous experience for me and the opportunity to review manuscripts that reflect the best in our field rema...

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Ferumoxytol enhanced black-blood cardiovascular magnetic resonance imaging

Cited by 13 publications

References 34 publications

Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI

Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI

Feasibility of 3D black-blood variable refocusing angle fast spin echo cardiovascular magnetic resonance for visualization of the whole heart and great vessels in congenital heart disease

Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review

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