Ferumoxide-enhanced magnetic resonance imaging techniques in pre-operative assessment for colorectal liver metastases

Sijp, Joost R.M. van der; Kruyt, R. H.; Oudkerk, Matthijs; Wiggers, Th.

doi:10.1053/ejso.2001.1251

Cited by 35 publications

(19 citation statements)

References 29 publications

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“…Sensitivity can be increased by the addition of other imaging modalities such as ultrasonography, CTAP 16 , MRI 17 or positron emission tomography 18 , and further information can be gained by serial measurement of carcinoembryonic antigen levels and the selective use of laparoscopy and laparoscopic ultrasonography 19 . At operation, the use of inspection, palpation and intraoperative ultrasonography has a sensitivity of 98 per cent and a specificity of 95 per cent in experienced hands 20 .…”

Section: Discussionmentioning

confidence: 99%

Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection

Jones

Rees

John

et al. 2005

British Journal of Surgery

108

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Section: Discussionmentioning

confidence: 99%

Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection

Jones

Rees

John

et al. 2005

British Journal of Surgery

108

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“…Although the sensitivity of unenhanced MRI has been reported to be 64%, 51 contrastenhanced MRI with agents such as gadolinium and ferumoxide has significantly improved the accuracy of detecting malignant liver tumors (80 to 90%). [65][66][67][68][69][70] Semelka et al 63 reported that gadolinium-enhanced MRI was as sensitive as CTAP in detecting liver metastases, but had a greater specificity. Ferumoxide is an intravenous contrast agent that contains iron particles and is captured in the Kupffer cells of normal liver parenchyma and benign lesions but not metastases.…”

Section: Imagingmentioning

confidence: 99%

Surgical Therapy for Colorectal Metastases to the Liver

Pawlik

Choti

2007

Journal of Gastrointestinal Surgery

203

118

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Colorectal cancer is the fourth most common type of cancer in the West and the second leading cause of cancer-related deaths in the United States. Approximately 35 to 55% of patients with colorectal cancer develop hepatic metastases during the course of their disease. Surgical resection of colorectal liver metastases represents the only chance at potential cure, and long-term survival can be achieved in 35 to 58% of patients after resection. The goal of hepatic resection should be to resect all metastases with negative histologic margins while preserving sufficient functional hepatic parenchyma. In patients with extensive metastatic disease who would otherwise be unresectable, ablative approaches can be used instead of or combined with hepatic resection. The use of portal vein embolization and preoperative chemotherapy may also expand the population of patients who are candidates for surgical treatment. Despite these advances, many patients still experience a recurrence after hepatic resection. More active systemic chemotherapy agents are now available and are being increasingly employed as adjuvant therapy either before or after surgery. Modern treatment of colorectal liver metastasis requires a multidisciplinary approach in an effort to increase the number of patients who may benefit from surgical treatment of colorectal cancer liver metastasis.

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“…Recently, two prospective studies on the use of CT and MRI in surgical candidates with colorectal liver metastases have been reported [22, 29]. Mann et al compared mangafodipir-enhanced MRI helical CT in preoperative assessment of liver metastases for resectability [22].…”

Section: Preoperative Assessment Of Surgical Candidatesmentioning

confidence: 99%

Liver metastases of colorectal cancer: US, CT or MR?

Schima

Kulinna²,

Langenberger³

et al. 2005

Cancer Imaging

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In contrast to other extrahepatic malignancies many colorectal cancers can be cured even when there is metastatic spread to the liver. The diagnosis of liver metastases relies totally on imaging to decide which patients may be surgical candidates. The diagnostic value of ultrasound with contrast agents, multidetector CT and MR imaging with non-specific gadolinium chelates and liver-specific contrast agent is discussed. Nowadays MDCT is the mainstay of staging and follow-up of these patients, because it provides good coverage of the liver and the complete abdomen and the chest in one session. MR imaging has been shown to be superior to helical CT in the preoperative assessment of colorectal liver metastases. Large studies are needed to define the role of MDCT vs. MRI staging in patients referred for resection of liver metastases.

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Ferumoxide-enhanced magnetic resonance imaging techniques in pre-operative assessment for colorectal liver metastases

Cited by 35 publications

References 29 publications

Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection

Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection

Surgical Therapy for Colorectal Metastases to the Liver

Liver metastases of colorectal cancer: US, CT or MR?

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