Feruloyl-CoA 6'-Hydroxylase1-Dependent Coumarins Mediate Iron Acquisition from Alkaline Substrates in Arabidopsis

Schmid, Nicole B.; Giehl, Ricardo Fabiano Hettwer; Döll, Stefanie; Mock, Hans Peter; Strehmel, Nadine; Scheel, Dierk; Kong, Xiaole; Hider, Robert C.; Wirén, Nicolaus von

doi:10.1104/pp.113.228544

Cited by 282 publications

(415 citation statements)

References 66 publications

(93 reference statements)

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“…Rodríguez-Celma et al (2013) showed that secretion of phenolics is critical for Arabidopsis Fe acquisition from low bioavailability sources, and then Fourcroy et al (2014) and Schmidt et al (2014) demonstrated that coumarins are the active compounds in this process. Schmid et al (2014) confirmed that secretion of coumarins is an essential aspect of Arabidopsis Fe acquisition and provided extensive information on metabolomic changes elicited by Fe deficiency. However, under certain conditions Fe is not readily available, and Fe is difficult to mobilize; thus, Fe stored in the plant needs to be reutilized.…”

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confidence: 52%

Putrescine Alleviates Iron Deficiency via NO-Dependent Reutilization of Root Cell-Wall Fe in Arabidopsis

et al. 2015

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Plants challenged with abiotic stress show enhanced polyamines levels. Here, we show that the polyamine putrescine (Put) plays an important role to alleviate Fe deficiency. The adc2-1 mutant, which is defective in Put biosynthesis, was hypersensitive to Fe deficiency compared with wild type (Col-1 of Arabidopsis [Arabidopsis thaliana]). Exogenous Put decreased the Fe bound to root cell wall, especially to hemicellulose, and increased root and shoot soluble Fe content, thus alleviating the Fe deficiency-induced chlorosis. Intriguingly, exogenous Put induced the accumulation of nitric oxide (NO) under both Fe-sufficient (+Fe) and Fe-deficient (-Fe) conditions, although the ferric-chelate reductase (FCR) activity and the expression of genes related to Fe uptake were induced only under -Fe treatment. The alleviation of Fe deficiency by Put was diminished in the hemicellulose-level decreased mutant-xth31 and in the noa1 and nia1nia2 mutants, in which the endogenous NO levels are reduced, indicating that both NO and hemicellulose are involved in Put-mediated alleviation of Fe deficiency. However, the FCR activity and the expression of genes related to Fe uptake were still up-regulated under -Fe+Put treatment compared with -Fe treatment in xth31, and Put-induced cell wall Fe remobilization was abolished in noa1 and nia1nia2, indicating that Put-regulated cell wall Fe reutilization is dependent on NO. From our results, we conclude that Put is involved in the remobilization of Fe from root cell wall hemicellulose in a process dependent on NO accumulation under Fe-deficient condition in Arabidopsis.

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confidence: 52%

Putrescine Alleviates Iron Deficiency via NO-Dependent Reutilization of Root Cell-Wall Fe in Arabidopsis

et al. 2015

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“…9), which was only half of that of the wild type and far below the critical level for chlorosis-free growth of Arabidopsis (Gruber et al, 2013;Schmid et al, 2014). Across many species, it is established that plants require 50 to 150 mg g 21 dry weight Fe (Marschner, 2012).…”

Section: Arabidopsis Mtp8 Mutants Are Altered In Mn and Fe Translocationmentioning

confidence: 99%

“…In Arabidopsis (Arabidopsis thaliana), a major contribution to Fe solubilization is made by phenolic compounds, in particular catechol-type coumarins, which act as bidentate or tridentate metal chelators and are released by roots of Fedeficient plants (Schmid et al, 2014). Although some coumarins have the additional ability to reduce Fe(III) (Schmid et al, 2014), Fe is primarily reduced by the activity of a membrane-bound reductase (FRO2 in Arabidopsis) that transfers electrons from cytosolic NADH to apoplastic Fe(III) chelates (Yi and Guerinot, 1996;Robinson et al, 1999). This enzymatic reduction process is facilitated by an acidification of the apoplast, which is mediated by an increased activity of plasma membrane-localized P-type H + -ATPases, such as AHA2 in Arabidopsis (Santi and Schmidt, 2009).…”

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confidence: 99%

The Vacuolar Manganese Transporter MTP8 Determines Tolerance to Iron Deficiency-Induced Chlorosis in Arabidopsis

et al. 2015

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“…Both these genes are strongly up-regulated by iron deficiency, and regulatory proteins governing the expression of these genes have been the subject of intense investigation (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005Yuan et al, , 2008Bauer et al, 2007;Wang et al, 2007;Long et al, 2010;Selote et al, 2015;Li et al, 2016;Mai et al, 2016). An additional component of iron uptake in nongraminaceous plants is the discovery that iron deficiency induces the secretion of phenolics and flavins (Rodríguez-Celma et al, 2013), later better defined as coumarins (Schmid et al, 2014) that are secreted by the ABCG37/PDR9 transporter (Fourcroy et al, 2014).…”

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confidence: 99%

Iron-Nicotianamine Transporters Are Required for Proper Long Distance Iron Signaling

et al. 2017

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The mechanisms of root iron uptake and the transcriptional networks that control root-level regulation of iron uptake have been well studied, but the mechanisms by which shoots signal iron status to the roots remain opaque. Here, we characterize an Arabidopsis (Arabidopsis thaliana) double mutant, yellow stripe1-like yellow stripe3-like (ysl1ysl3), which has lost the ability to properly regulate iron deficiency-influenced gene expression in both roots and shoots. In spite of markedly low tissue levels of iron, the double mutant does not up-and down-regulate iron deficiency-induced and -repressed genes. We have used grafting experiments to show that wild-type roots grafted to ysl1ysl3 shoots do not initiate iron deficiency-induced gene expression, indicating that the ysl1ysl3 shoots fail to send an appropriate long-distance signal of shoot iron status to the roots. We present a model to explain how impaired iron localization in leaf veins results in incorrect signals of iron sufficiency being sent to roots and affecting gene expression there. Improved understanding of the mechanism of long-distance iron signaling will allow improved strategies for the engineering of staple crops to accumulate additional bioavailable iron in edible parts, thus improving the iron nutrition of the billions of people worldwide whose inadequate diet causes iron deficiency anemia.

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Feruloyl-CoA 6'-Hydroxylase1-Dependent Coumarins Mediate Iron Acquisition from Alkaline Substrates in Arabidopsis

Cited by 282 publications

References 66 publications

Putrescine Alleviates Iron Deficiency via NO-Dependent Reutilization of Root Cell-Wall Fe in Arabidopsis

Putrescine Alleviates Iron Deficiency via NO-Dependent Reutilization of Root Cell-Wall Fe in Arabidopsis

The Vacuolar Manganese Transporter MTP8 Determines Tolerance to Iron Deficiency-Induced Chlorosis in Arabidopsis

Iron-Nicotianamine Transporters Are Required for Proper Long Distance Iron Signaling

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