Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota

Abstract

The prevalence of hyperuricemia (HUA) has been rising, which is typically accompanied by renal injury and intestinal flora disorder, leading to a non-negligible health crisis. Ferulic acid (FA), as a...

Effect of ferulic acid and p‐coumaric acid on lowering uric acid through network pharmacology and in vitro studies

“…Both ferulic acid and p ‐coumaric acid reversed this effect, decreased URAT1 and GLUT9 transporter protein expression, and increased ABCG2 expression, alleviating hyperuricemia by reducing UA reabsorption and promoting UA excretion. This is consistent with previous studies that ferulic acid can alleviate hyperuricemia in vitro and in vivo (Zhang et al., 2023). Zhu et al.…”

“…The hyperuricemia cell model was constructed by inducing HK‐2 cells with UA solution (Zhang et al., 2023). The cell concentration was adjusted to 8 × 10 4 cells/mL in a 96‐well plate (100 μL medium per well), maintaining the cells in logarithmic phase.…”

Exploring the clinical efficacy and mechanism of high-position colon dialysis combined with Traditional Chinese Medicine retention enema in real-world patients with stage 3–5 chronic kidney disease (non-dialysis) based on the theory of the Gut–Kidney axis

“…Astragalus membranaceus Bunge combined with S. miltiorrhiza Bunge can regulate the NF-κB/HIF-α signalling pathway, downregulate the expression of P65, p-P65, and HIF-1α, inhibit the mesenchymal transition of renal tubular epithelial cells, and reduce the deposition of extracellular matrix and collagen fibres, thereby delaying the process of renal interstitial fibrosis ( Qin, 2021 ). Research has shown that the main component of L. chuanxiong Hort, ferulic acid, can remodel the composition of the gut microbiota, characterized by an increase in beneficial bacteria (e.g., Lactobacillus and Ruminococcus ) and a decrease in pathogenic bacteria (e.g., Bacteroides ) ( Zhang et al, 2023 ). Although current research on these drugs as primary components of enema prescriptions is mainly based on oral administration, research on rectal administration is relatively scarce.…”

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

“…Another highly meaningful study involved the administration of Ferulic acid (FA) to rats on a high fructose/high fat diet (HFFD). FA significantly reduced average serum uric acid levels, blood urea nitrogen, and creatinine levels ( 248 ). The expression of urate transport proteins was reduced, while that of secretory transport proteins increased in both the kidneys and intestines of the rats.…”

“…The expression of urate transport proteins was reduced, while that of secretory transport proteins increased in both the kidneys and intestines of the rats. FA was also found to mitigate renal oxidative stress, inhibit the activation of the TLR4/NF-κB pathway, and suppress the activation of downstream inflammatory response markers ( 248 ). Additionally, sequencing revealed that FA altered the composition of the gut microbiota, characterized by an increase in beneficial bacteria (e.g., Lactobacillus and Ruminococcus ) and a decrease in pathogenic bacteria (e.g., Bacteroides ) ( 248 ).…”