Ferulic acid solubility in supercritical carbon dioxide, ethanol and water mixtures

Bitencourt, Raphaela Gabrí; Cabral, Fernando A.; Meirelles, Antônio J. A.

doi:10.1016/j.jct.2016.08.025

Cited by 48 publications

(38 citation statements)

References 40 publications

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“…This value was little deviated from its value reported by Cairong et al . Overall, the mole fraction solubility of FA in water at T = 298.2 K was very close with our previous work, while it was deviated with those reported by Bitencourt et al . and Cairong et al .…”

Section: Resultssupporting

confidence: 79%

“…The solubility data of FA in various (IPA + water) mixtures at different temperature have not been reported previously in the literature. However, the solubility data of FA in neat water and neat IPA at different temperature have been reported in the literature . The solubility (mole fraction) of FA in water at ‘ T = 298.2 K’ was obtained as 1.00 × 10 −4 by Bitencourt et al .…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, these computational models were applied in this work. The solubility data of FA in water at different temperatures have been reported by many researchers . The solubility data of FA in IPA at five different temperatures under atmospheric pressure have also been reported in the literature .…”

Section: Introductionmentioning

confidence: 87%

“…The chemical name of isopropyl alcohol (IPA) is isopropanol which could be utilized as a great cosolvent in the solubilization of bioactive compounds. Different computational models have been proposed for the correlation and curve fitting of experimental solubility data of solutes with calculated ones . Van't Hoff, Apelblat, Yalkowsky and Jouyban–Acree models are the commonly used computational models for this purpose .…”

Section: Introductionmentioning

confidence: 99%

“…Ferulic acid (FA) (molecular structure: Figure 1; chemical name: 4-hydroxy-3-methoxycinnamic acid; molecular formula: C 10 H 10 O 4 ; molar mass: 194.18 g/mol; and CAS registry number: 1325-24-6) occurs as white to off-white crystalline solid. [1,2] It is obtained from various parts of plants such as 'fruits, grains, vegetables and leaves'. [2][3][4][5][6] It is a phenolic compound which had various applications in biomedical, pharmaceutical and food industries.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures

Haq

Siddiqui

Shakeel

2017

Journal of Pharmacy and Pharmacology

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures

Haq

Siddiqui

Shakeel

2017

Journal of Pharmacy and Pharmacology

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Ferulic acid and human platelet lysate incorporated alginate dialdehyde‐gelatin 3D (bio)printable hydrogels with biological activity

Bider,

Klotschan,

Kuth

et al. 2024

J of Applied Polymer Sci

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This study investigates the creation of multifunctional scaffolds based on alginate dialdehyde (ADA) and gelatin (GEL) incorporating ferulic acid (FA), a phytotherapeutic agent with diverse pharmacological properties, and human platelet lysate (HPL). The multimaterial hydrogels were characterized in terms of degradation/swelling behavior showing that HPL decelerates the degradation process of ADA‐GEL hydrogels in absence of FA. A FA release study confirmed that the presence of HPL does not affect the FA release ability of ADA‐GEL hydrogel. A trinitrobenzenesulfonic acid (TNBS) assay confirmed no influence of HPL on the Schiff's base formation. The addition of HPL was shown to lead to a decrease in stiffness, mechanical stability, and viscosity of ADA‐GEL‐HPL inks. This effect was also observed for ADA‐GEL‐HPL inks when investigating their three‐dimensional (3D) printing ability. Cytocompatibility tests and a 3D bioprinting study confirmed the beneficial impact of the addition of HPL on MC3T3‐E1 cells. Moreover, an antibacterial effect provided by the addition of FA was confirmed while the incorporation of HPL led to higher VEGF‐A expression by MC3T3‐E1 cells. Overall, the addition of HPL and FA to ADA‐GEL hydrogel results in a promising ink, which has potential for future biofabrication applications.

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Exploring the binding mechanism of ferulic acid and ovalbumin: insights from spectroscopy, molecular docking and dynamics simulation

Chen

Zhu

et al. 2022

J Sci Food Agric

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BACKGROUND: Ferulic acid (FA), a phenolic acid widely occurring in nature, has attracted extensive attention because of its biological activity. Ovalbumin (OVA) is a commonly used carrier protein. The mechanism of FA binding with OVA was investigated by utilizing a variety of spectral analyses, accompanied by computer simulation. RESULTS: It was discovered that the fluorescence quenching mechanism of OVA by FA was a static mode as a result of the formation of an FA−OVA complex, which was verified by the concentration distributions and pure spectrum of the constituents decomposed from the high overlap spectrum signals using multivariate curve resolution-alternate least squares algorithm. Hydrogen bonds and Van der Waals forces drove the formation of FA-OVA complex with a binding constant of 1.69 × 10 4 L mol −1 . The presence of FA induced the loose structure of OVA with an attenuation of ⊍-helix content and improved the thermal stability of OVA. Computer docking indicated that FA interacted with the amino acid residues Arg84, Asn88, Leu101 and Ser103 of OVA through hydrogen bonds. Molecular dynamics simulation proved that the combination of FA with OVA boosted the conformational stability of OVA and hydrogen bonds brought a crucial part in stabilizing the structure of the complex. CONCLUSIONS:The study may supply the theoretical basis for the design of FA transport system using OVA as carrier protein to improve the instability and low bioavailability of FA.

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Ferulic acid solubility in supercritical carbon dioxide, ethanol and water mixtures

Cited by 48 publications

References 40 publications

Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures

Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures

Ferulic acid and human platelet lysate incorporated alginate dialdehyde‐gelatin 3D (bio)printable hydrogels with biological activity

Exploring the binding mechanism of ferulic acid and ovalbumin: insights from spectroscopy, molecular docking and dynamics simulation

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