Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long-Evans Tokushima Fatty diabetic rats

Fujita, Atsuyo; Sasaki, Hideyuki; Doi, Asako; Okamoto, K.; Matsuno, Shohei; Furuta, Hiroto; Nishi, Masahiro; Nakao, Taisei; Tsuno, T; Taniguchi, Hiroya; Nanjo, Kishio

doi:10.1016/j.diabres.2007.08.009

Cited by 43 publications

(27 citation statements)

References 28 publications

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“…Renal lesions in OLETF rats were characterized by thickening of the glomerular basement membrane, mesangial expansion, sclerotic lesions, interstitial fibrosis (29) and interstitial lymphocyte infiltration (30). In this study, histological appearances revealed findings comparable to these observations.…”

Section: Thiamine Mitigated Albuminuria Renal Interstitial Fibrosissupporting

confidence: 76%

Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats

Tanaka

Kono

Terasaki

et al. 2010

J Nutr Sci Vitaminol

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SummaryWe previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of thiamine transporter gene SLC19A2 is linked to type 2 diabetes mellitus. The current study extends our hypothesis that thiamine intervention may impact metabolic abnormalities in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, exhibiting obesity and metabolic disorders similar to human metabolic syndrome. Male OLETF rats (4 wk old) were given free access to water containing either 0.2% or 0% of thiamine for 21 and 51 wk. At the end of treatment, blood parameters and cardiac functions were analyzed. After sacrifice, organs weights, histological findings, and hepatic pyruvate dehydrogenase (PDH) activity in the liver were evaluated. Thiamine intervention averted obesity and prevented metabolic disorders in OLETF rats which accompanied mitigation of reduced lipid oxidation and increased hepatic PDH activity. Histological evaluation revealed that thiamine alleviated adipocyte hypertrophy, steatosis in the liver, heart, and skeletal muscle, sinusoidal fibrosis with formation of basement membranes (called pseudocapillarization) which accompanied significantly reduced expression of laminin ␤ 1 and nidogen-1 mRNA, interstitial fibrosis in the heart and kidney, fatty degeneration in the pancreas, thickening of the basement membrane of the vasculature, and glomerulopathy and mononuclear cell infiltration in the kidney. Cardiac and renal functions were preserved in thiamine treatment. Thiamine has a potential to prevent obesity and metabolic disorders in OLETF rats.

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Section: Thiamine Mitigated Albuminuria Renal Interstitial Fibrosissupporting

confidence: 76%

Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats

Tanaka

Kono

Terasaki

et al. 2010

J Nutr Sci Vitaminol

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“…It has been hypothesized that an increase in oxidative stress as a result of chronic hy- perglycemia activates several signaling pathways that alter gene expression (Chiu et al, 2009). Recent studies have suggested that inflammation plays a role in the progression of diabetic nephropathy (Fujita et al, 2008;Ko et al, 2008). Accordingly, many studies have focused on slowing down the progress of diabetic nephropathy by reducing oxidative stress as well as controlling blood glucose and blood pressure levels.…”

Section: Introductionmentioning

confidence: 99%

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

et al. 2011

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Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation.

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“…There are reports that glomerulosclerosis inhibited or decreased by Vit C, alpha lipoic acid, Vit E (30-32) and ferolic acid, a polyphenolic antioxidant in diabetic rats (33). Coenzyme Q10 also ameliorated glomerulosclerosis and improved tissue antioxidant enzymes in diabetic rat (34).…”

Section: Results From Antioxidant Therapy In Experimental Diabetic Nementioning

confidence: 99%

Diabetic nephropathy and antioxidants

Tavafi¹

2013

J Nephropathol

132

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Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long-Evans Tokushima Fatty diabetic rats

Cited by 43 publications

References 28 publications

Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats

Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

Diabetic nephropathy and antioxidants

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