Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism

Niu, Chengwei; Sheng, Yuchen; Zhu, Enyuan; Ji, Lili; Wang, Zhengtao

doi:10.5582/bst.2016.01152

Cited by 19 publications

(16 citation statements)

References 36 publications

(42 reference statements)

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“…These results indicated that ferulic acid regulated the inflammatory biomarkers induced by HFD, which are determinant factors in lipid and glucose homeostasis. Our results are consistent with previous reports, which showed that ferulic acid has anti-inflammatory properties because of the decrease in the expression of the transcription factor inhibitor of kappa B (IκB), and the increase of the nuclear translocation of the p65 subunit of nuclear factor kappa B (NFκBp65) [ 10 ]. Furthermore, ferulic acid may contribute to the modulation of inflammatory processes through suppression of NO production by downregulating the expression of NF-κB-mediated iNOS gene [ 32 ].…”

Section: Discussionsupporting

confidence: 93%

“…The above results are consistent with Senaphan et al [ 9 ], who showed that ferulic acid alleviates changes in metabolic syndrome in rats through suppression of oxidative stress by down-regulation of p47phox, increased nitric oxide (NO) bioavailability with upregulation of endothelial nitric oxide synthase (eNOS) and suppression of TNF-α [ 9 ]. Ferulic acid also prevents acute liver injury by inhibiting intrahepatic inflammation and liver apoptosis in mice via the reduction of hepatocellular degeneration, lymphocyte infiltration, the number of apoptotic hepatocytes, serum levels of tumor necrosis factor alpha (TNF-α) and interferon-γ (IFN-γ), and liver myeloperoxidase (MPO) activity [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

et al. 2017

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Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases. An integral evaluation of the effects of ferulic acid on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Three groups of male Wistar rats (six per group) consumed a basal diet (BD), which was supplemented with either lard at 310 g/kg (HFD) or lard and ferulic acid at 2 g/kg (HFD + FA), ad libitum for eight weeks. Body weight gain, hyperplasia, and hypertrophy in abdominal fat tissues were higher in the HFD group than in the HFD+FA group. The rats fed a HFD + FA significantly inhibited the increase in plasma lipids and glucose, compared with the HFD group. Biomarkers associated with inflammation were found at higher concentrations in the serum of rats fed a HFD than the HFD + FA group. Plasma antioxidant levels were lower in HFD rats compared to rats fed the HFD + FA. These results suggest that ferulic acid improves the obesogenic status induced by HFD, and we elucidated the integral effects of ferulic acid on a biological system.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

et al. 2017

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“…The serum ALT and AST levels are the most sensitive indicators of the liver damage and indirectly reflect the extent of the liver damage [ 30 ]. The increasing serum of ALT and AST would indicate liver cell damage or necrosis [ 31 ]. Our data suggested that the serum ALT and AST levels induced by alcohol in the DOFE group could be effectively downregulated.…”

Section: Discussionmentioning

confidence: 99%

Dendrobium officinale Flower Extraction Mitigates Alcohol-Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti-Inflammatory

Sihan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The study aimed to evaluate the protective effect of Dendrobium officinale flower extraction (DOFE) on alcohol-induced liver injury and its probable mechanisms in mice. The chemical composition of DOFE was performed via UPLC/MS. Male Kunming mice were used to establish alcohol-induced liver injury models by oral gavage of 56% alcohol. Results showed that DOFE dramatically attenuated the increased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and triacylglycerol (TG). Meanwhile, hematoxylin and eosin and Oil Red O staining showed that DOFE attenuated degeneration, inflammatory infiltration, and lipid droplet accumulation. DOFE was also found to suppress the activity of malonaldehyde (MDA) and enhanced the level of glutathione (GSH) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the liver. The protection of DOFE against oxidative stress was associated with the downregulation of hepatic cytochrome P450 2E1 (CYP2E1) and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase l (NQO1). Additionally, DOFE suppressed inflammation via downregulating Toll-like receptor-4 (TLR-4) and nuclear factor kappa-B P65 (NF-κB P65). Thus, DOFE exhibited a significant protective effect against alcohol-induced liver injury through its antisteatosis, antioxidative, and anti-inflammatory effect.

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“…The iodine content in AL mix was quantified as 263 µg/g of AL. Since, FA has various pharmacological activities such as antioxidant, anti‐inflammation, anti‐Alzheimer, anticancer, and hapato‐protective effects (Niu, Sheng, Zhu, Ji, & Wang, ), whereas iodine is an important element for thyroid hormone synthesis and has been used as dietary supplements to prevent thyroid diseases by the intake of seaweeds (Zava & Zava, ), they might be involved to work harmoniously on the prevention of hypothyroidism and its related liver damages in the present study.…”

Section: Discussionmentioning

confidence: 95%

“…The iodine content in AL mix was quantified as 263 µg/g of AL. Since, FA has various pharmacological activities such as antioxidant, anti-inflammation, anti-Alzheimer, anticancer, and hapato-protective effects (Niu, Sheng, Zhu, Ji, & Wang, 2016),…”

Section: Discussionmentioning

confidence: 99%

Protective effects of a mixed plant extracts derived fromAstragalus membranaceusandLaminaria japonicaon PTU‐induced hypothyroidism and liver damages

et al. 2019

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Protective effects of a mixed hot water extracts of Astragalus membranaceus (AWE) and Laminaria japonica (LWE), AWE: LWE 85:15 (g/g; AL mix), were investigated against propylthiouracil (PTU)‐induced hypothyroidism in rats. Rats were challenged with PTU, resulting in, increased thyroid gland weight, decreased liver weight and antioxidant activities, reduced serum tri‐iodothyronine and thyroxine levels with increased thyroid stimulating hormone levels, and elevated serum aspartate aminotransferase level. However, orally administered AL mix with 100, 200, and 400 mg kg−1 day−1, significantly inhibited such abnormalities, dose‐dependently. Moreover, PTU‐induced abnormal histological architecture of the rat thyroid gland and liver were also significantly ameliorated by an AL mix. The results suggested that, therapeutic use of AL mix for treating hypothyroidism can be characterized by its diversified active ingredients particularly iodine and ferulic acid as confirmed by phytochemical analyses. Practical applications The AL mix has synergistic effects in modulating thyroid hormone synthesis and preventing liver damages in PTU‐induced hypothyroid rats. These effects of AL mix are mainly related to its richness specifically in iodine and ferulic acid. The growing interests of iodine and ferulic acid in AL mix are principally due to their beneficial effects in releasing sufficient thyroid hormones in hypothyroid conditions and promoting liver‐protective functions through its antioxidant and anti‐inflammatory potentials, respectively. Moreover, the results of AL mix are well‐matched with the effects of standard drug levothyroxine in the present study. Therefore, appropriate dosage of AL mix will be promising as new medicinal food for preventing thyroid dysfunctions and its related liver damages.

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Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism

Cited by 19 publications

References 36 publications

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

Dendrobium officinale Flower Extraction Mitigates Alcohol-Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti-Inflammatory

Protective effects of a mixed plant extracts derived fromAstragalus membranaceusandLaminaria japonicaon PTU‐induced hypothyroidism and liver damages

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