Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells

Rampelotto, Camila Reck; Pereira, Viviane Gonçalves; Silveira, Larissa da Silva; Rossato, Aline; Machado, Alencar Kolinski; Sagrillo, Michele Rorato; Gündel, André; Burger, Marilise Escobar; Schaffazick, Scheila Rezende; Silva, Cristiane de Bona da

doi:10.1016/j.tiv.2021.105259

Cited by 11 publications

(15 citation statements)

References 71 publications

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“…The sesamol-loaded nanocapsule suspensions showed an encapsulation efficiency of 65%, which was expected due to the low partition coefficient (Log P of 1.29) favoring the sesamol partition to the external aqueous phase [ 37 ]. Our results agree with previous studies performed with ethylcellulose nanocapsules presenting a similar qualitative and quantitative composition [ 16 , 35 , 38 ]. In those studies, the formulations showed the absence of microparticles, an average size of approximately 200 nm, PDI values lower than 0.2, a negative zeta potential and a controlled drug release profile.…”

Section: Discussionsupporting

confidence: 93%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.

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Section: Discussionsupporting

confidence: 93%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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“…Based on the good results obtained for NE-FA MCT (1.5 mg/mL) in the characterization and stability, further studies were chosen to be continued. Additionally, there is no evidence in the literature of any study successfully associating FA with the concentration used in the selected nanoemulsion, and most studies report concentrations of up to 1.0 mg/mL of FA in nanostructured systems and nanoemulsions. ,,− ,,,, …”

Section: Results and Discussionmentioning

confidence: 99%

“…The separation was obtained using an RP C18 Inertesil column (150 mm × 4.60 mm; 5 μm; Gl Science) coupled to a C18 guard column at room temperature. The method for the FA determination was previously validated by our research group in relation to specificity, linearity (2.5, 5.0, 10.0, 20.0, and 40.0 μg/mL), accuracy, and precision …”

Section: Methodsmentioning

confidence: 99%

“…The in vitro release study was performed according to the dialysis bag diffusion technique in triplicate batches . Observing sink conditions, a phosphate buffer solution (PBS) of pH 5.5 and 7.4 was used as the medium, and the experiment was performed at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

“…There are some studies that developed FA-loaded nanostructured carriers as nanostructured lipid carriers, ,− polymeric nanocapsules, − and nanoemulsions. , …”

Section: Introductionmentioning

confidence: 99%

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