Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

Ren, Zhongkun; Zhang, Rongping; Li, Yuanyuan; Yu, Li; Yang, Zhiyong; Yang, Hui

doi:10.3892/ijmm.2017.3127

Cited by 145 publications

(88 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TLR4 identifies exogenous pathogens by binding to lipopolysaccharides of Gram-negative bacteria, stimulating the production of antimicrobial peptides, and inducing nonspecific immune responses such as activation of the NF-κB pathway in macrophages. FA was previously documented to prevent apoptotic cell death by suppressing oxidative stress and the expression of Bax, TLR4, and caspase-3 genes [27]. Based on our findings, we propose that FA inhibits NF-κB activation by a downstream mechanism involving TLR4.…”

Section: Discussionsupporting

confidence: 74%

Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Porcine parvovirus (PPV) infection-induced apoptosis was recently identified as an important pathological factor in PPV-induced placental tissue damage, resulting in reproduction failure. In the present study, we demonstrate the possible involvement of toll-like receptor (TLR) 4 and nuclear factor (NF)-κB inflammasome activation in PPV infection-induced apoptosis and the protective potential of ferulic acid (FA). PPV infection significantly activated the expression levels of TLR4, NF-κB, MyD88, and interleukin (IL)-6. However, FA ameliorated the pathological process, prevented histological alterations, and inhibited the apoptosis rate in porcine kidney (PK-15) cells infected with PPV. Results. FA inhibited PPV infection-induced inflammasome activation as shown by decreases in the expression of NF-κB, MyD88, and IL-6. FA also downregulated nonstructural (NS) 1 protein expression in infected PK-15 cells. Conclusions. FA downregulated NS1 and TLR4 signaling, prevented the overproduction of reactive oxygen species, and suppressed the NF-κB inflammasome axis to inhibit PPV-induced apoptosis in PK-15 cells.

show abstract

Section: Discussionsupporting

confidence: 74%

Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Ferulic acid (FA), originally isolated from herbs used in Chinese medicine, has attracted attention from medical professionals as an antioxidant because it reacts with free radicals . It exerts antitumor activity and inhibits metastasis of breast cancer cells by regulating epithelial to mesenchymal transition, and it exerts neuroprotective effects against cerebral ischemia/reperfusion‐induced injury via antioxidant and antiapoptotic mechanisms . Recently, FA was also shown to inhibit the clot retraction responsible for platelet development .…”

Section: Resultsmentioning

confidence: 99%

“…13 It exerts antitumor activity and inhibits metastasis of breast cancer cells by regulating epithelial to mesenchymal transition, 14 and it exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and antiapoptotic mechanisms. 15 Recently, FA was also shown to inhibit the clot retraction responsible for platelet development. 16 However, the difference between the influence on the cell and the living body due to the introduction of a bromide onto FA is unclear.…”

Section: In Vitro Assay Of Fa and 6-bfamentioning

confidence: 99%

Characterization of 6‐bromoferulic acid as a novel common‐use matrix for matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry

Kato

Hirosawa

Sakamoto

et al. 2020

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Rationale Ferulic acid (FA) is a standard matrix used for analyzing proteins. In this study, the ability of a halogenated FA to serve as an effective MALDI matrix was investigated. Various halogenated FAs were synthesized, and the characteristics and performance of each were compared with those of the standard matrices α‐cyano‐4‐hydroxycinnamic acid (CHCA) and 2,5‐dihydrobenzoic acid (DHBA). Methods The abilities of 6‐bromoferulic acid (6‐BFA), ferulic acid (FA), and eight other halogenated FA derivatives to ionize eight synthetic peptides were examined. Absorption measurements, MM2 structure optimizations, and proton affinity (PA) calculations were also performed for 6‐BFA and FA. The suitabilities of these compounds as matrices for matrix‐assisted laser desorption/ionization (MALDI) for lipids, sugar chains, polymers, cyanocobalamin, synthetic peptides, and tryptic peptides originating from two types of serum proteins were also tested. Results The 6‐position of FA was found to be the best site for introducing a bromine because the generated compound allowed facile detection of cyanocobalamin and several peptides. 6‐BFA exhibited good sensitivity for large peptides (3–5 kDa) and peptides containing acidic amino acids or proline. 6‐BFA was also shown to be a suitable matrix for tandem mass spectrometry (MS/MS) analysis when using MALDI time‐of‐flight (TOF) mass spectrometry (MS) with a quadrupole ion trap (QIT) system. Conclusions The properties of 6‐BFA as a MALDI matrix differed from those of DHBA and CHCA. 6‐BFA appears to be a useful matrix for de novo sequencing using MALDI‐QIT‐TOF‐MS.

show abstract

“…Ferulic acid (FA) is a widely distributed constituent of plants that can treat cerebrovascular diseases and cerebral ischemia by protecting neurons from degeneration and regulating inflammatory activity [14][15][16]. However, it is unknown whether the administration of FA has a neuroprotective effect on HIBD; furthermore, the potential mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-9 Mediated the Protective Effect of Ferulic Acid on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Yao

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Abbreviations: HIBD, hypoxic-ischemic brain damage; HI, hypoxia-ischemia; FA, ferulic acid; SF, sodium ferulic; qRT-PCR, quantitative real-time PCR; AchE, acetylcholinesterase; PSD-95, postsynaptic density protein-95; miR-9, microRNA-9; LNA-miR-9: locked nucleic acid-miR-9; DG, dentate gyrus.Abstract--Neonatal hypoxic-ischemic brain damage (NHIBD) leads to cognitive and memory impairments, and there is no effective clinical treatment. Ferulic acid (FA)is found within members of the genus Angelica, reportedly shows protective effects on neuronal damage; however, the mechanism of the protective effects of FA on rats following NHIBD remains unclear. Using the Morris water maze task, we herein found that the impairment of spatial memory formation in adult rats exposed to NHIBD was significantly reversed by FA treatment and the administration of LNA-miR-9. RT-PCR analyses revealed that miRNA-9 was significantly increased in the hippocampus of neonatal rats and neuronal PC12 cells following NHIBD and that FA and LNA-miR-9 both inhibited the expression of miRNA-9, suggesting that the therapeutic effect of FA was mainly attributed to the inhibition of miRNA-9 expression. Indeed, the silencing of miR-9 by LNA-miR-9 or FA similarly attenuated neuronal damage and cerebral atrophy in the rat hippocampus after NHIBD, which was consistent with the restored expression levels of brain-derived neurotrophic factor (BDNF). Therefore, FA treatment may protect against neuronal death through the inhibition of miRNA-9 induction in the rat hippocampus following hypoxic-ischemic damage.

show abstract

Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

Cited by 145 publications

References 71 publications

Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1

Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1

Characterization of 6‐bromoferulic acid as a novel common‐use matrix for matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry

MicroRNA-9 Mediated the Protective Effect of Ferulic Acid on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Contact Info

Product

Resources

About