Ferulic Acid Esters and Weight-Loss Promoting Effects in Rats

Totani, Nagao; Tateishi, Sayuri; Takimoto, Tatsuya; Shinohara, Risa; Sasaki, Hideaki

doi:10.5650/jos.61.331

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…In addition, ferulic acid may protect against vascular endothelial dysfunction in diabetic rats when combined with astragaloside IV through regulation of the nuclear factor-κB (NF-κB) pathway 12. Antioxidant effects of ferulic acid have also been demonstrated in previous studies 12–14. Hepatoprotective effects of ferulic acid have been demonstrated in studies using diosbulbin B and carbon tetrachloride (CCl4) as initiators of liver fibrosis 15–17…”

Section: Introductionmentioning

confidence: 93%

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Mu¹,

Zuo²,

Wu³

et al. 2018

DDDT

141

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PurposeLiver fibrosis is a worldwide health issue. Development of effective new drugs for treatment of this disease is of great importance. This study investigated the therapeutic effects of ferulic acid on liver fibrosis in vitro and in vivo.Materials and methodsHuman hepatic stellate cell line (HSC) LX-2 was used for in vitro assays. Transforming growth factor β1 (TGF-β1) was used to induce hepatic fibrosis in LX-2 cells. Western blot was used to detect protein levels of collagen I, fibronectin, α-smooth muscle actin (SMA), p-Smad2, p-Smad3, p-p38, and p-JNK. Gene expression was measured by RT-qPCR. Fluorescence staining was used to determine localization of Smad4. CCl4-induced hepatic fibrosis in SD rats was used as an in vivo model. Histological features were detected by hematoxylin and eosin staining. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hexadecenoic acid (HA), and hydroxyproline (Hyp) were measured by ELISA.ResultsTGF-β1 treatment significantly increased levels of collagen I, fibronectin, α-SMA, p-Smad2, p-Smad3, and Smad4 in LX-2 cells. Ferulic acid improved TGF-β1-induced hepatic fibrosis via regulation of the TGF-β1/Smad pathway. Consistent with in vitro data, CCl4 caused severe hepatic fibrosis in SD rats, as determined by ALT, AST, HA, and Hyp upregulation. Protein levels of p-Smad2 and p-Smad3 in liver tissues were significantly increased following treatment with CCl4. All CCL4-induced changes were markedly attenuated by ferulic acid treatment.ConclusionFerulic acid potently improved hepatic fibrosis via inhibition of the TGF-β1/Smad pathway in vitro and in vivo. These findings provided evidence for potential use of ferulic acid to treat or prevent liver fibrosis.

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Section: Introductionmentioning

confidence: 93%

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Mu¹,

Zuo²,

Wu³

et al. 2018

DDDT

141

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“…El propóleo contiene una variedad de compuestos químicos que pueden explicar la disminución de la adiposidad encontrada. Se ha demostrado que el ácido ferúlico promueve la pérdida de peso en las ratas y mejora la glucemia en los ratones alimentados con una dieta alta en grasas (28,29). El kaempferol mejora la hiperglucemia, la hiperinsulinemia y el perfil lipídico (30).…”

Section: Minerales Totalesunclassified

Body composition, mineral metabolism, and endocrine function of adipose tissue: influence of a nutritional supplement of propolis

González¹,

Botella²,

Soto³

et al. 2021

Nutr Hosp

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“…For example, treatment with CA has been reported to improve hyperglycemia and hepatic steatosis in animals kept on a high calorie diet, but obesity, hypertriglyceridemia and hypercholesterolemia were not always prevented ( 6 7 8 9 ). In addition, multiple studies indicate that treatment with CA improves dyslipidemia and minimizes fasting hyperglycemia, but does not always prevent diet-induced obesity ( 10 11 12 13 ).…”

Section: Introductionmentioning

confidence: 99%

Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

Bocco

Fernandes

Lorena

et al. 2016

Braz J Med Biol Res

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Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.

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Ferulic Acid Esters and Weight-Loss Promoting Effects in Rats

Cited by 8 publications

References 10 publications

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Body composition, mineral metabolism, and endocrine function of adipose tissue: influence of a nutritional supplement of propolis

Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

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Ferulic Acid Esters and Weight-Loss Promoting Effects in Rats

Cited by 8 publications

References 10 publications

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-&beta;/Smad signaling pathway

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-&beta;/Smad signaling pathway

Body composition, mineral metabolism, and endocrine function of adipose tissue: influence of a nutritional supplement of propolis

Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

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Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway