Ferulic acid and hormesis: Biomedical and environmental implications

Calabrese, Edward J.; Agathokleous, Evgenios; Calabrese, Vittorio

doi:10.1016/j.mad.2021.111544

Cited by 33 publications

(11 citation statements)

References 86 publications

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“…Furthermore, gallic acid is heat stable compound that is not decomposed at temperatures up to 100 °C; therefore, thermal degradation should be disregarded and can be used instead of some synthetic antioxidants in food industry [38] . Ferulic acid is also widely known as antioxidant and it is abundant in fruit and vegetable including seed and leaf; therefore, by product from plant can be used as a rich source of ferulic acid [12] . In addition, the caffeic acid commonly found in plant and propolis has been reported that it provides excellent free radical scavenging ability and can be commercially used to protect polyunsaturated oils [51] .…”

Section: Resultsmentioning

confidence: 99%

Optimization of ultrasound extraction of functional compound from makiang seed by response surface methodology and antimicrobial activity of optimized extract with its application in orange juice

Sirichan

Kijpatanasilp

Asadatorn

et al. 2022

Ultrasonics Sonochemistry

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Highlights Optimization of ultrasound-assisted extraction of makiang seed was evaluated. Variable parameters including temperature, time and amplitude were analyzed. Ultrasound had a significant effect on bioactive compound of makiang seed. Makiang seed extract showed antioxidant and antimicrobial activities. Makiang seed extract enhanced microbial stability of orange juice during storage.

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Section: Resultsmentioning

confidence: 99%

Optimization of ultrasound extraction of functional compound from makiang seed by response surface methodology and antimicrobial activity of optimized extract with its application in orange juice

Sirichan

Kijpatanasilp

Asadatorn

et al. 2022

Ultrasonics Sonochemistry

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show abstract

“…The biomedical literature now comprises vast experimental findings on hormetic effects with a broad spectrum of plant‐derived agents that induce chemopreventive effects in multiple systems in a similar manner as resveratrol 72 . All the major dietary supplements such as curcumin, 76 Ginkgo biloba , 77 ginseng, 78 green tea extracts, 79 olive based products, 80 ferulic acid, 81 luteolin, 82 rosmarinic acid, 83 garlic, 84 and numerous other agents have been shown to commonly display hormetic dose responses in multiple cellular systems, affecting a wide range of important public health endpoints.…”

Section: Food Science Discovers Hormesis: Building Resilience and Enh...mentioning

confidence: 99%

Hormesis: Transforming disciplines that rely on the dose response

Calabrese

Agathokleous

2021

IUBMB Life

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This article tells the story of hormesis from its conceptual and experimental origins, its dismissal by the scientific and medical communities in the first half of the 20th century, and its rediscovery over the past several decades to be a fundamental evolutionary adaptive strategy. The upregulation of hormetic adaptive mechanisms has the capacity to decelerate the onset and reduce the severity of a broad spectrum of common age‐related health, behavioral, and performance decrements and debilitating diseases, thereby significantly enhancing the human health span. Incorporation of hormetic‐based lifestyle options within the human population would have profoundly positive impacts on the public health, significantly reducing health care costs.

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“…Ferulic acid is the main active organic acid component of the classic natural medicine Chuanxiong [ 143 ]. In Chuanxiong, ferulic acid exists in both bound and free forms.…”

Section: Natural Medicinal Plants and Active Ingredients In The Regul...mentioning

confidence: 99%

Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy

Wang

Liu

2022

Oxidative Medicine and Cellular Longevity

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Heart failure occurs because of various cardiovascular pathologies, such as coronary artery disease or cardiorenal syndrome, eventually reaching end-stage disease. Various factors contribute to cardiac structural or functional changes that result in systolic or diastolic dysfunction. Several studies have confirmed that the key factor in heart failure progression is myocardial cell death, and mitophagy is the major mechanism regulating myocardial cell death in heart failure. The clinical mechanisms of heart failure are well understood in practice. However, the essential role of mitophagic regulation in heart failure has only recently received widespread attention. Receptor-mediated mitophagy is involved in various mitochondrial processes like oxidative stress injury, energy metabolism disorders, and calcium homeostasis, which are also the main causes of heart failure. Understanding of the diverse regulatory mechanisms in mitophagy and the complexity of its pathophysiology in heart failure remains incomplete. Related studies have found that various natural medicinal plants and active ingredients, such as flavonoids and saponins, can regulate mitophagy to a certain extent, improve myocardial function, and protect myocardial cells. This review comprehensively covers the relevant mechanisms of different types of mitophagy in regulating heart failure pathology and controlling mitochondrial adaptability to stress injury. Further, it explores the relationship between mitophagy and cardiac ejection dysfunction. Natural medicinal plant-targeted regulation strategies and scientific evidence on mitophagy were provided to elucidate current and potential strategies to apply mitophagy-targeted therapy for heart failure.

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Ferulic acid and hormesis: Biomedical and environmental implications

Cited by 33 publications

References 86 publications

Optimization of ultrasound extraction of functional compound from makiang seed by response surface methodology and antimicrobial activity of optimized extract with its application in orange juice

Optimization of ultrasound extraction of functional compound from makiang seed by response surface methodology and antimicrobial activity of optimized extract with its application in orange juice

Hormesis: Transforming disciplines that rely on the dose response

Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy

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