Ferulic acid: An extraordinarily neuroprotective phenolic acid with anti-depressive properties

Dong, Xiaoyu; Huang, Rui

doi:10.1016/j.phymed.2022.154355

Cited by 21 publications

(8 citation statements)

References 167 publications

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“…Ferulic acid (FA) ([E]−3-[4-hydroxy-3-methoxy-phenyl] prop-2-enoic acid) is a phenolic compound commonly found in some fruits ( Lorigooini et al, 2020b ). Numerous pharmacological properties have been reports for FA counting anti-inflammatory, antioxidant, anticancer, anxiolytic cardioprotective, neuroprotective and antidiabetes effects ( Nile et al, 2016 , Zheng et al, 2019 , Pandi et al, 2022 , Dong and Huang, 2022 ). It has been determined that FA through its anti-oxidant and anti-inflammatory properties exerted nephroprotective effects in cyclosporine-induced nephrotoxicity in rats ( Ghasemi-Dehnoo et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Balali-Dehkordi,

Habibian-Dehkordi,

Amini-Khoei

et al. 2024

IBRO Neuroscience Reports

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Section: Discussionmentioning

confidence: 99%

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Balali-Dehkordi,

Habibian-Dehkordi,

Amini-Khoei

et al. 2024

IBRO Neuroscience Reports

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“…Natural phenols can be beneficial to health because they cause a reduction in the risk of developing neurological and psychiatric diseases ( Vermerris and Nicholson, 2008 ; Szwajgier et al, 2017 ). Many authors have reported the neuroprotective role of various phenolic acids in controlling epilepsy and ameliorating anxiety and depression, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, and Parkinson’s disorder ( Szwajgier et al, 2017 ; Fasipe et al, 2020 ; Cordeiro et al, 2022 ; De Vries et al, 2022 ; Dong and Huang, 2022 ). Ellagic acid has antioxidant, anti-inflammatory, and neuroprotective properties ( Ríos et al, 2022 ).…”

Section: Phenols and Neuropsychiatric Disordersmentioning

confidence: 99%

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov,

Zaichenko,

Moskovtsev

et al. 2024

Front. Pharmacol.

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γ-Aminobutyric acid type A receptors (GABAARs) are members of the pentameric ligand-gated ion channel (pLGIC) family, which are widespread throughout the invertebrate and vertebrate central nervous system. GABAARs are engaged in short-term changes of the neuronal concentrations of chloride (Cl−) and bicarbonate (HCO3−) ions by their passive permeability through the ion channel pore. GABAARs are regulated by various structurally diverse phenolic substances ranging from simple phenols to complex polyphenols. The wide chemical and structural variability of phenols suggest similar and different binding sites on GABAARs, allowing them to manifest themselves as activators, inhibitors, or allosteric ligands of GABAAR function. Interest in phenols is associated with their great potential for GABAAR modulation, but also with their subsequent negative or positive role in neurological and psychiatric disorders. This review focuses on the GABAergic deficit hypotheses during neurological and psychiatric disorders induced by various phenols. We summarize the structure–activity relationship of general phenol groups concerning their differential roles in the manifestation of neuropsychiatric symptoms. We describe and analyze the role of GABAAR subunits in manifesting various neuropathologies and the molecular mechanisms underlying their modulation by phenols. Finally, we discuss how phenol drugs can modulate GABAAR activity via desensitization and resensitization. We also demonstrate a novel pharmacological approach to treat neuropsychiatric disorders via regulation of receptor phosphorylation/dephosphorylation.

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“…The investigation employed a lot of the drug curcumin, and the action was discovered to be synergistic. The HPA axis and the disrupted monoaminergic pathways may be brought into balance by large-scale sequential therapy options for depression 60 .…”

Section: Curcuminmentioning

confidence: 99%

Role of Phytoflavonoids in the Management of Anxiety and Depression: An Overview

Mazumder,

Khan,

Saini

2023

JNR

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The main global health issue, anxiety, and depression have significant psychological, social, and financial repercussions. It promotes an anticipatory and adaptable reaction to difficult or stressful situations. When anxiety is excessive, it destabilizes the person, which leads to a dysfunctional state. In the absence of intense situations, it’s a pathological state. It comprises posttraumatic stress disorder, general anxiety, aversion to social situations, obsessive-compulsive disorder, and panic disorder. Some people think about using natural therapies as an alternative to anxiety drugs because they may cause negative side effects. Due to their natural origins and lack of adverse effects, these medications and herbal medicine are becoming more and more popular in both developed and developing nations. Minerals, organic matter, and medicinal plants are the sources of many traditional remedies. Alkaloids, also saponins, glycosides, flavonoids, which, etc. are all present. The goal of this summary is to provide in-depth knowledge about the many phytoconstituents that have the potential to reduce anxiety and play a significant role in CNS activity.

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Ferulic acid: An extraordinarily neuroprotective phenolic acid with anti-depressive properties

Cited by 21 publications

References 167 publications

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Role of Phytoflavonoids in the Management of Anxiety and Depression: An Overview

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