Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue

Ghasemi‐Dehnoo, Maryam; Amini‐Khoei, Hossein; Lorigooini, Zahra; AnjomShoa, Maryam; Rafieian-Kopaei, Mahmoud

doi:10.1007/s10787-023-01277-y

Cited by 16 publications

(6 citation statements)

References 67 publications

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“…Atractylenolide III inhibits hippocampal neuronal inflammation triggering anxiolytic-depressive effects [ 45 ], and also downregulates histamine and IL-6 levels following MCs activation to modulate immune response [ 46 ]. Phenolic acids like Ferulic acid regulate NF-κB associated pathways to induce anti-inflammatory and anti-apoptotic effects in rats with enteritis [ 47 ]. Gallic acid can prevent the formation of colonic adhesins and cuprocytes, thereby improving intestinal inflammation and reducing oxidative stress [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Guo,

Lu,

Yang

et al. 2024

PLoS ONE

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Aim of the study To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq). Materials and methods A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats. Histopathological changes in the colon and alterations in mast cell (MC) count were determined. Immunohistochemistry was employed to assess mast cell tryptase (MCT) expression in rat colons. Serum levels of corticotropin-releasing Hormone (CRH), interleukin-6 (IL-6), calcitonin gene-related peptide (CGRP), and 5-hydroxytryptamine (5-HT) were quantified using ELISA. RNA-Seq of colon tissue was performed, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Western blot analysis was conducted to quantify the expression levels of key proteins in the Nr4a3 pathway in the colon and hypothalamus tissues of rats. Results SYNC alleviated visceral hypersensitivity and mood disorders in rats with IBS-D. Moreover, it was positively correlated with its dosage and the observed effects, such as the enhancement of the colon’s mucosal lining condition and reduction in the number and activation of MCs within the model group. SYNC reduced the expression levels of factors related to the brain-gut axis and inflammatory markers in the bloodstream. RNA-Seq analysis indicated that SYNC down-regulated the expression of Nr4a3 and PI3K. These SYNC-targeted genes primarily played roles in immune regulation and inflammatory responses, correlating with the modulation of Nr4a3 and the PI3K/AKT pathway. Western blot analysis further confirmed SYNC’s influence on inflammation-related MC activation by downregulating key proteins in the Nr4a3/PI3K pathway. Conclusions SYNC inhibited mast cell activation and attenuated visceral hypersensitivity in the colon tissues of IBS-D rats. These effects were mediated by the Nr4a3/PI3K signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Guo,

Lu,

Yang

et al. 2024

PLoS ONE

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“…Numerous pharmacological properties have been reports for FA counting anti-inflammatory, antioxidant, anticancer, anxiolytic cardioprotective, neuroprotective and antidiabetes effects ( Nile et al, 2016 , Zheng et al, 2019 , Pandi et al, 2022 , Dong and Huang, 2022 ). It has been determined that FA through its anti-oxidant and anti-inflammatory properties exerted nephroprotective effects in cyclosporine-induced nephrotoxicity in rats ( Ghasemi-Dehnoo et al, 2023 ). Some studies have been reported that FA exerted antinociceptive effects ( Xu et al, 2016 , Xu et al, 2013 ), however, the detailed and complete underlying mechanisms mediating the antinociceptive effects of FA are not understood.…”

Section: Discussionmentioning

confidence: 99%

“…The requisite specific primers were planned using Primer 3 software version 0.4.0 ( http://frodo.wi.mit.edu ). The H2afz gene was used as a normalizer to compare the expression of favorite genes ( Ghasemi-Dehnoo et al, 2023 ). Lastly, the data gained from Real-time RT-PCR were considered using the PFAFFL formula.…”

Section: Rt-pcr For Evaluation Of Gene Expression Of Inflammatory Mar...mentioning

confidence: 99%

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Balali-Dehkordi,

Habibian-Dehkordi,

Amini-Khoei

et al. 2024

IBRO Neuroscience Reports

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“…Ferulic acid, administered at doses of 20, 40, and 60 mg/kg, significantly increased the activity of antioxidant factors, including TAC content and SOD and CAT activity, in the colon tissue of rats with acetic acid-induced colitis [46]. Animals treated with sinapic acid at a dose of 40 mg/kg exhibited a noteworthy replenishment in mean CAT and GSH levels compared to those with acetic acid-induced colitis, indicating a restoration of free radical scavenging activity [47].…”

Section: Effect Of Phenolic Acids On Oxidative Stressmentioning

confidence: 95%

“…Ferulic acid, administered at doses of 20, 40, and 60 mg/kg, significantly inhibited the mRNA expression of inflammatory and apoptotic genes in the colon tissue of rats with acetic acid-induced colitis [46]. Additionally, at doses of 20 and 40 mg/kg, ferulic acid ameliorated TNBS-induced colitis by inhibiting the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6, AND IL-10) and downregulating COX-2 synthesis [35,36].…”

Section: Effect Of Phenolic Acids On Immune Systemmentioning

confidence: 95%

Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease

Lu,

Han

2024

Nutrients

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Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder, and its complex etiology makes prevention and treatment challenging. Research on new drugs and treatment strategies is currently a focal point. Phenolic acids are widely present in plant-based diets and have demonstrated the potential to alleviate colitis due to their powerful antioxidant and anti-inflammatory properties. In this review, we provide an overview of the structures and main dietary sources of phenolic acids, encompassing benzoic acid and cinnamic acid. Additionally, we explore the potential of phenolic acids as a nutritional therapy for preventing and treating IBD. In animal and cell experiments, phenolic acids effectively alleviate IBD induced by drug exposure or genetic defects. The mechanisms include improving intestinal mucosal barrier function, reducing oxidative stress, inhibiting excessive activation of the immune response, and regulating the balance of the intestinal microbiota. Our observation points towards the need for additional basic and clinical investigations on phenolic acids and their derivatives as potential novel therapeutic agents for IBD.

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Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue

Cited by 16 publications

References 67 publications

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Ferulic acid via attenuation of oxidative stress and neuro-immune response utilizes antinociceptive effect in mouse model of formalin test

Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease

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