Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Tuli, Hardeep Singh; Kumar, Ajay; Ramniwas, Seema; Coudhary, Renuka; Aggarwal, Diwakar; Kumar, Manoj; Sharma, Ujjawal; Parashar, Nidarshana Chaturvedi; Haque, Shafiul; Sak, Katrin

doi:10.3390/molecules27217653

Cited by 29 publications

(21 citation statements)

References 90 publications

(76 reference statements)

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“…It is more soluble in dimethylformamide, ethyl acetate and alcoholic solvents than in water (0.91 mg/mL, logP = 1.51). 24,25 It generates a phenoxyl radical that is resonancestabilized. However, this substance is only stable up to 150 °C and completely degrades above 226 °C.…”

Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

“…However, this substance is only stable up to 150 °C and completely degrades above 226 °C. 24 Ferulic acid is distinguished from other compounds by the presence of a carboxyl group and hydroxyl as well as methoxy groups. 16 The double bond between C2−C3 and the hydroxyl groups at C1 and C9 of ferulic acid are thought to be the primary sources of the compound's effective bioactivity and antioxidant capabilities, respectively.…”

Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

“…The two primary methods used to extract caffeic acid from its sources are high-temperature processing and solvent extraction. 24 Caffeic acid is present in monomers, dimers, and trimers, or bound to proteins in the cell walls of vegetables. 36 Due to its outstanding antioxidant properties, it is making a splash in the food packaging and diesel storage sectors.…”

Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

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The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson’s disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included “hydroxycinnamic acid derivatives,” “ferulic acid,” “caffeic acid,” “sinapic acid,” “p-coumaric acid,” “Parkinson’s disease,” and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.

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Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

Section: Physical Properties and Chemistry Of Hydroxycinnamic Acid De...mentioning

confidence: 99%

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The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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“…It rarely occurs in a free state and is typically conjugated with mono, oligosaccharides, polysaccharides, polyamines, and lipids. Multiple studies have shown a wide range of biological effects by FA against clinical conditions, including, cancer, diabetes, lung, and cardiovascular diseases [ 108 , 152 , 153 ]. It also shows hepatic, neuro, and photoprotective effects.…”

Section: Phenolic Acids Involved In the Regulation Of Molecular Targetsmentioning

confidence: 99%

“…FA had been proposed as a promising anticancer agent with potential therapeutic benefits that include antiproliferative, proapoptotic, antiangiogenic, and/or antimetastatic effects in different experimental cancer models influencing multiple molecular targets and cellular signaling pathways [ 108 ]. Karimvand et al [ 155 ] reported a significant increase in apoptosis index characterized by decreased Bcl-2 expression and higher Bax expression after FA treatment in renal carcinoma.…”

Section: Phenolic Acids Involved In the Regulation Of Molecular Targetsmentioning

confidence: 99%

Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives

et al. 2023

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Cancer is a global health concern with a dynamic rise in occurrence and one of the leading causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the seventh most diagnosed malignant tumor, while among the gynecological malignancies, it ranks third after cervical and uterine cancer and sadly bears the highest mortality and worst prognosis. First-line treatments have included a variety of cytotoxic and synthetic chemotherapeutic medicines, but they have not been particularly effective in extending OC patients’ lives and are associated with side effects, recurrence risk, and drug resistance. Hence, a shift from synthetic to phytochemical-based agents is gaining popularity, and researchers are looking into alternative, cost-effective, and safer chemotherapeutic strategies. Lately, studies on the effectiveness of phenolic acids in ovarian cancer have sparked the scientific community’s interest because of their high bioavailability, safety profile, lesser side effects, and cost-effectiveness. Yet this is a road less explored and critically analyzed and lacks the credibility of the novel findings. Phenolic acids are a significant class of phytochemicals usually considered in the nonflavonoid category. The current review focused on the anticancer potential of phenolic acids with a special emphasis on chemoprevention and treatment of OC. We tried to summarize results from experimental, epidemiological, and clinical studies unraveling the benefits of various phenolic acids (hydroxybenzoic acid and hydroxycinnamic acid) in chemoprevention and as anticancer agents of clinical significance.

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Influence of extraction solvents on the chemical constituents and biological activities of Astragalus aduncus from Turkey flora: In vitro and in silico insights

Lazarova,

Nilofar,

Caprioli

et al. 2024

Archiv der Pharmazie

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The n‐hexane, ethyl acetate, ethanol, ethanol/water (70% ethanol), and water extracts of Astragalus aduncus aerial parts were investigated for their antioxidant potential, enzyme inhibition activity (anti‐acetylcholinesterase [AChE], anti‐butyrylcholinesterase [BChE], antityrosinase, antiamylase, and antiglucosidase) and antiproliferative effect (against colon adenocarcinoma cell line [HT‐29], gastric cancer cell line [HGC‐27], prostate carcinoma cell line [DU‐145], breast adenocarcinoma cell line [MDA‐MB‐231], and cervix adenocarcinoma cell line [HeLa]). In addition, the phytochemical profile of the extracts was evaluated using validated spectrophotometric and high‐pressure liquid chromatography‐electrospray ionization/tandem mass spectroscopy methods. Generally, the 70% ethanol extract demonstrated the strongest antioxidant properties, and it was the richest source of total phenolic constituents. Our findings indicated that the ethyl acetate extract was the most potent BChE inhibitor (11.44 mg galantamine equivalents [GALAE]/g) followed by the ethanol extract (8.51 mg GALAE/g), while the ethanol extract was the most promising AChE inhibitor (3.42 mg GALAE/g) followed by the ethanol/water extract (3.17 mg GALAE/g). Excellent tyrosinase inhibitory activity (66.25 mg kojic acid equivalent/g) was observed in ethanol/water extracts of the aerial part of A. aduncus. Тhese results showed that the most cytotoxic effects were exhibited by the ethyl acetate extract against HGC‐27 cells (IC50: 36.76 µg/mL), the ethanol extract against HT‐29 cells (IC50: 30.79 µg/mL), and the water extract against DU‐145 cells (IC50: 37.01 µg/mL). A strong correlation was observed between the highest total flavonoid content and the highest content of individual compounds in the ethanol extract, including rutin, hyperoside, isoquercitrin, delphinidin‐3,5‐diglucoside (delphinidin‐3,5‐O‐diglucoside), and kaempferol‐3‐glucoside (kaempferol‐3‐O‐glucoside). In the present study, the A. aduncus plant was considered a new source of antioxidants, enzyme inhibitors, and anticancer agents and could be used as a future health‐benefit natural product.

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Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Cited by 29 publications

References 90 publications

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives

Influence of extraction solvents on the chemical constituents and biological activities of Astragalus aduncus from Turkey flora: In vitro and in silico insights

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