Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells

Gastrointestinal (GI) cancer is a prevailing global health disease with a high incidence rate which varies by region. It is a huge economic burden on health care providers. GI cancer affects different organs in the body such as the gastric organs, colon, esophagus, intestine, and pancreas. Internal and external factors like smoking, obesity, urbanization, genetic mutations, and prevalence of Helicobacter pylori and Hepatitis B and Hepatitis C viral infections could increase the risk of GI cancer. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in fruits, grains, and vegetables. Consumption of phytochemicals may protect against chronic diseases like cardiovascular disease, neurodegenerative disease, and cancer. Multiple studies have assessed the chemoprotective effect of selected phytochemicals in GI cancer, offering support to their potential towards reducing the pathogenesis of the disease. The aim of this review was to summarize the current knowledge addressing the anti-cancerous effects of selected dietary phytochemicals on GI cancer and their molecular activities on selected mechanisms, i.e., nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), detoxification enzymes, adenosine monophosphate activated protein kinase (AMPK), wingless-related integration site/β-catenin (wingless-related integration site (Wnt) β-catenin, cell apoptosis, phosphoinositide 3-kinases (PI3K)/ protein kinase B AKT/ mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK). In this review phytochemicals were classified into four main categories: (i) carotenoids, including lutein, lycopene, and β-carotene; (ii) proanthocyanidins, including quercetin and ellagic acid; (iii) organosulfur compounds, including allicin, allyl propyl disulphide, asparagusic acid, and sulforaphane; and (iv) other phytochemicals including pectin, curcumins, p-coumaric acid and ferulic acid. Overall, phytochemicals improve cancer prognosis through the downregulation of β-catenin phosphorylation, therefore enhancing apoptosis, and upregulation of the AMPK pathway, which supports cellular homeostasis. Nevertheless, more studies are needed to provide a better understanding of the mechanism of cancer treatment using phytochemicals and possible side effects associated with this approach.

show abstract

“…Ferulic acid is a bioactive component found in rice bran [195]. Rice bran is one of the byproducts produced by the milling process of rice [196].…”

Section: Ferulic Acidmentioning

confidence: 99%

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

2020

View full text Add to dashboard Cite

show abstract

“…Ferulic acid (FA) is a strong membrane antioxidant and known to be an effective scavenger of free radicals [22]. It has been shown to induce cell apoptosis through loss of mitochondrial membrane potential [23]. Twenty-five FA metabolites were found in the plasma, most of which were also found in the urine, while in the feces, colonic metabolism led to simpler phenolic compounds [22].…”

Section: Phenolic Acidsmentioning

confidence: 99%

“…Twenty-five FA metabolites were found in the plasma, most of which were also found in the urine, while in the feces, colonic metabolism led to simpler phenolic compounds [22]. Ferulic acid intake reduced NADPH oxidase activity, superoxide release, apoptosis and necrosis in peripheral blood mononuclear cells in mice [23]. Superoxide production was abrogated by FA in rats [24].…”

Section: Phenolic Acidsmentioning

confidence: 99%

Red Beetroot and Betalains as Cancer Chemopreventative Agents

Lechner¹,

Stoner²

2019

Preprint

View full text Add to dashboard Cite

Carcinogenesis is the process whereby a normal cell is transformed into a neoplastic cell.  This action involves several steps starting with initiation and followed by promotion and progression.  Driving these stages are oxidative stress and inflammation, which in turn encompasses a myriad of aberrant gene expressions, both within the transforming cell population and the cells within the surrounding lesion.  Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs via normalizing these inappropriate gene activities.  Various foods/agents have been shown to affect different gene expressions.  In this review we discuss whereby the chemoprevention activities of the red beetroot itself may disrupt carcinogenesis and the activities of the water soluble betalains extracted from the plant.

show abstract

“…Such products, including active ingredients of traditional Chinese medicine (TCM), also often exhibit specific high selectivity and biological activities through their ability to regulate multiple signaling pathways [18]. Ferulic acid (FA), a natural product isolate from TCM, is a phenolic compound with antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, and antiviral properties [19][20][21]. We previously found that FA inhibited PPV replication through the mitochondrial apoptosis pathway.…”

Section: Introductionmentioning

confidence: 99%

Ferulic Acid Protects against Porcine Parvovirus Infection‐Induced Apoptosis by Suppressing the Nuclear Factor‐κB Inflammasome Axis and Toll‐Like Receptor 4 via Nonstructural Protein 1

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Porcine parvovirus (PPV) infection-induced apoptosis was recently identified as an important pathological factor in PPV-induced placental tissue damage, resulting in reproduction failure. In the present study, we demonstrate the possible involvement of toll-like receptor (TLR) 4 and nuclear factor (NF)-κB inflammasome activation in PPV infection-induced apoptosis and the protective potential of ferulic acid (FA). PPV infection significantly activated the expression levels of TLR4, NF-κB, MyD88, and interleukin (IL)-6. However, FA ameliorated the pathological process, prevented histological alterations, and inhibited the apoptosis rate in porcine kidney (PK-15) cells infected with PPV. Results. FA inhibited PPV infection-induced inflammasome activation as shown by decreases in the expression of NF-κB, MyD88, and IL-6. FA also downregulated nonstructural (NS) 1 protein expression in infected PK-15 cells. Conclusions. FA downregulated NS1 and TLR4 signaling, prevented the overproduction of reactive oxygen species, and suppressed the NF-κB inflammasome axis to inhibit PPV-induced apoptosis in PK-15 cells.

show abstract

Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells

Cited by 60 publications

References 49 publications

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

Red Beetroot and Betalains as Cancer Chemopreventative Agents

Ferulic Acid Protects against Porcine Parvovirus Infection‐Induced Apoptosis by Suppressing the Nuclear Factor‐κB Inflammasome Axis and Toll‐Like Receptor 4 via Nonstructural Protein 1

Contact Info

Product

Resources

About