Ferucrin isobutyrate and ferucrinone fromFerula foetidissima

Kir'yanova, I. A.; Sklyar, Yu. E.

doi:10.1007/bf00580081

Cited by 3 publications

(3 citation statements)

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“…We analyzed the stereochemistry by 2D NMR, ECD, and single-crystal X-ray analysis. The results established the absolute configurations of compounds 1-5 and 10, and for the first time clarified the absolute configurations of compounds 2, 4, and 5, which had been reported in the literature only with their relative configurations [22,23]. Moreover, a detailed analysis of the 2D-NMR spectra produced a systematic assignment of compounds 2-6 for the first time.…”

Section: Resultssupporting

confidence: 74%

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Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors

Xing

Zhou

et al. 2016

Planta Med

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Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identified sixteen bioactive sesquiterpene coumarins (two new and fourteen known ones) in the effective extract of . Further, the anti-neuroinflammatory activities in BV-2 microglial cells were evaluated by monitoring LPS-induced nitric oxide production. In conclusion, the major constituent, (3', 5', 8', 9', 10')-kellerin (1.5 %, w/w), should be responsible for the anti-neuroinflammatory effect exhibited by Awei. Furthermore, it might be a potential natural therapeutic agent for Alzheimer's disease. The research indicated moreover, that its primary mechanism is the inhibition of mRNA expression of the inflammatory cytokines nitric oxide, tumor necrosis factor-α, cyclooxygenase-2, interleukin-6 and interleukin-1.

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Section: Resultssupporting

confidence: 74%

“…We identified fourteen known sesquiterpene coumarins as (5′ S, 8′R, 9′S, 10′R)-ferukrinone (2) [22], ferukrin 3 [32], and umbelliprenin (16) [33] (▶ Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors

Xing

Zhou

et al. 2016

Planta Med

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“…Due to the presence of multiple substituent sites and substituents, the structures of sesquiterpenes are diverse. Here, sesquiterpenes with medicinal or potential medicinal prospects are summarized, including 88 daucane-type sesquiterpenes (1-88), 27 guaiane-type sesquiterpenes (89-115), 13 humulane-type sesquiterpenes (116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128), 11 eudesmane-type sesquiterpenes (129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139), 3 germacrane-type sesquiterpenes (140)(141)(142), 1 elemane-type sesquiterpene (143), and 6 other types of sesquiterpenes (144)(145)(146)(147)(148)(149). The names and sources of compounds 1-149 are listed in Table 1, and their chemical structures are shown in Figure 2.…”

Section: Chemical Structures 21 Sesquiterpenesmentioning

confidence: 99%

Sesquiterpenes and Sesquiterpene Derivatives from Ferula: Their Chemical Structures, Biosynthetic Pathways, and Biological Properties

Wang,

Zheng,

Wang

et al. 2023

Antioxidants

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Ferula is a genus of flowering plants known for its edible and medicinal properties. Since ancient times, many species of Ferula have been used in traditional medicine to treat various health issues across countries, such as digestive disorders, respiratory problems, and even as a remedy for headaches and toothaches. In addition, they are also used as a flavoring agent in various cuisines. As the main active ingredients in Ferula, sesquiterpenes and their derivatives, especially sesquiterpene coumarins, sesquiterpene phenylpropanoids, and sesquiterpene chromones, have attracted the attention of scientists due to the diversity of their chemical structures, as well as their extensive and promising biological properties, such as antioxidative, anti-inflammatory, antibacterial properties. However, there has not been a comprehensive review of sesquiterpenes and their derivatives from this plant. This review aims to provide an overview of the chemical structures, biosynthetic pathways, and biological properties of sesquiterpenes and sesquiterpene derivatives from Ferula, which may help guide future research directions and possible application methods for this valuable edible and medicinal plant.

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Sesquiterpene coumarins from Ferula sinkiangensis K.M.Shen and their cytotoxic activities

Wang

Zhang

et al. 2020

Phytochemistry

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Ferucrin isobutyrate and ferucrinone fromFerula foetidissima

Cited by 3 publications

References 0 publications

Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors

Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors

Sesquiterpenes and Sesquiterpene Derivatives from Ferula: Their Chemical Structures, Biosynthetic Pathways, and Biological Properties

Sesquiterpene coumarins from Ferula sinkiangensis K.M.Shen and their cytotoxic activities

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