The rapid increase in the anthropogenic production of N fertilizers has been a major factor accounting for the growth in agricultural food production. Despite the overall benefits the United States has experienced from use of reactive N, major environmental problems (e.g., soil and water acidification, contamination of surface and groundwater resources, increased ozone depletion and greenhouse gas levels, and loss of biodiversity) have developed due to the presence of excessive environmental N. The objective of this paper is to review research which is examining the use of enhanced‐efficiency fertilizers, such as slow‐ (SRF) and controlled‐release fertilizers (CRF), nitrification inhibitors (NI), and urease inhibitors (UI), as one management practice to enhance fertilizer N effectiveness, and possibly decrease environmental N losses through processes, such as nitrate leaching and runoff and gaseous losses of nitrous oxide and ammonia.