Fertilization and neonatal outcomes after early rescue intracytoplasmic sperm injection: a retrospective analysis of 16,769 patients

Zeng, Jun; Yao, Zhongyuan; Zhang, Yeqing; Fen, Tian; Liao, Tingting; Wu, Lingqian; Li, Yanping

doi:10.1007/s00404-022-06445-z

Cited by 9 publications

(20 citation statements)

References 50 publications

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“…However, Cao et al (2016) believed that early R‐ICSI is not recommended for cycles with a fertilization rate of >25%, as enough available pure IVF embryos are in these cycles. Considering the stress and financial costs associated with fertility treatment, the indication of early R‐ICSI was defined as the fertilization rate of <50% in our center, as opposed to the indication of other centers (fertilization rate < 30%) (Jiang et al, 2021; Zeng et al, 2022). The main obstacles to expanding indication lay with increasing embryologists' workload and polyspermy rate.…”

Section: Discussionmentioning

confidence: 99%

Fertilization, pregnancy, and neonatal outcomes after IVF, rescue ICSI, and ICSI in unexplained infertility: A retrospective study

Qiu,

Zuo,

Xue

et al. 2024

Molecular Reproduction Devel

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Conventional intracytoplasmic sperm injection (ICSI) is not recommended for nonmale infertile patients to avoid fertilization failure (FF) in view of controversies regarding safety issues. Among the strategies that may help to promote the use of in vitro fertilization (IVF) for women with a high risk of FF, rescue ICSI (R‐ICSI) has attracted attention. This study aimed to evaluate the efficacy of short‐term insemination combined with early R‐ICSI in the treatment of unexplained infertility. A total of 952 controlled ovarian stimulation (COS) cycles for unexplained infertility were divided into short‐term IVF (short‐term insemination without R‐ICSI, n = 500), R‐ICSI (short‐term insemination with R‐ICSI, n = 141), and ICSI (conventional ICSI, n = 311) groups. Patients underwent consecutive transfer cycles until live birth, or until all embryos from the first COS cycle were used. Laboratory data and clinical outcomes from short‐term IVF, R‐ICSI, and ICSI groups were compared. Short‐term IVF and ICSI groups were superior to R‐ICSI group in polyspermy rate, available embryo rate, and top‐quality embryos rate. Short‐term IVF, R‐ICSI, and ICSI groups underwent 705 (500 fresh and 205 frozen‐thawed cycles), 190 (141 fresh and 49 frozen‐thawed cycles), and 445 (311 fresh and 134 frozen‐thawed cycles) transfer cycles, resulting in 294, 76, and 190 live birth cycles, respectively. Comparison of pregnancy outcomes among these three groups demonstrated similar clinical pregnancy rates and live birth rates in fresh and frozen‐thawed embryo transfer cycles. There was no significant difference in the cumulative live birth rate among these three groups. R‐ICSI group showed similar neonatal outcomes compared with short‐term IVF and ICSI groups, including the rates of low birth weight, fetal macrosomia, small for gestational age and large for gestational age. Short‐term insemination combined with early R‐ICSI achieved satisfactory pregnancy and neonatal outcomes, albeit with a high polyspermy rate, which was an effective alternative to avoid excessive use of ICSI in unexplained infertility.

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Section: Discussionmentioning

confidence: 99%

Fertilization, pregnancy, and neonatal outcomes after IVF, rescue ICSI, and ICSI in unexplained infertility: A retrospective study

Qiu,

Zuo,

Xue

et al. 2024

Molecular Reproduction Devel

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“…In this study, we selected primary infertility patients with age ≤ 35 years and ≥ 5 oocytes in their rst Re-ICSI/ICSI cycle to minimize the in uence of age and oocytes factor. In the early R-ICSI cycles, especially part of oocytes R-ICSI cycles, the embryos come from short-term insemination embryos and R-ICSI embryos together (Zeng et al 2022). In this study, the embryos transferred all from R-ICSI fertilizaion.…”

Section: The Pregnancy Outcomes Of Fet In R-icsi and Icsi Groupsmentioning

confidence: 92%

“…Rates of clinical pregnancy, implantation, ectopic pregnancy, abortion, sex ratio, and live birth were not signi cantly different in the two groups in SVBT cycle (Table 2). When is the right time to perform R-ICSI that can achieve a better outcome (Zeng et al 2022)? For the second polar body at more or less 6 h, performing R-ICSI after 6 h of coincubation can salvage cases with fertilization failure in IVF.…”

Section: The Pregnancy Outcomes Of Fet In R-icsi and Icsi Groupsmentioning

confidence: 99%

“…In the R-ICSI group, the sperms were micro-injected into oocytes 4-6 h later compared with those in the ICSI group. The differences of pregnancy outcomes of R-ICSI/ICSI probably because of the oocyte aging and subsequent embryonic development (Zeng et al 2022).…”

Section: The Pregnancy Outcomes Of Fet In R-icsi and Icsi Groupsmentioning

confidence: 99%

“…There is insu cient evidence to suggest ICSI use in couples without male factor infertility (Paffoni et al 2021). To avoid total fertilization failure or low fertilization in conventional in vitro fertilization (IVF), short co-incubation of gametes combined with early-rescue intracytoplasmic sperm injection (R-ICSI) is an optimal strategy (Zeng et al 2022). Some studies indicated that short insemination had no detrimental effects on clinical outcomes in human IVF and early R-ICSI could attain acceptable pregnancy outcomes (He et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Comparing the pregnancy outcomes of fresh and frozen embryo transfer after early rescue ICSI

Jiang¹,

Yuan²,

Song³

et al. 2023

Preprint

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Context: Early-rescue intracytoplasmic sperm injection (R-ICSI) can avoid total fertilization failure in conventional in vitro fertilization (IVF). However, the R-ICSI embryos had lower implantation rate than the direct ICSI in the fresh embryo transfer. Aims: To investigate the effect of frozen embryo transfer (FET)after R-ICSI. Methods: This was a retrospective study of the first cycle primary infertility patients with the age ≤ 35 undergoing R-ICSI and ICSI treatment. The clinical pregnancy rate, implantation rate, ectopic pregnancy, abortion rate and live birth rate were analyzed between the R-ICSI and ICSI groups in their first embryo transfer (fresh and FET cycles). Key Results: The average age of patients in fresh and frozen ET of two groups was (29.1±3.1 vs. 29.0±3.2, and 28.9±3.0 vs. 29.1±3.3), respectively (P>0.05). The R-ICSI embryos clinical pregnancy rate, implantation rate and live birth rate were lower than the ICSI embryos in fresh embryo transfer. Whereas there were no significant difference between R-ICSI and ICSI embryos in the FET cycle. Conclusions: R-ICSI embryos with frozen embryo transfer would be an optimal strategy rather than fresh embryo transfers. Implications:early R-ICSI combined with frozen embryo transfer could achieve satisfying clinical outcomes compared with fresh embryo transfers.

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The role of maternal physical activity on in vitro fertilization outcomes: a systematic review and meta-analysis

Kakargia

Mamalakis

Frountzas

et al. 2022

Arch Gynecol Obstet

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Fertilization and neonatal outcomes after early rescue intracytoplasmic sperm injection: a retrospective analysis of 16,769 patients

Cited by 9 publications

References 50 publications

Fertilization, pregnancy, and neonatal outcomes after IVF, rescue ICSI, and ICSI in unexplained infertility: A retrospective study

Fertilization, pregnancy, and neonatal outcomes after IVF, rescue ICSI, and ICSI in unexplained infertility: A retrospective study

Comparing the pregnancy outcomes of fresh and frozen embryo transfer after early rescue ICSI

The role of maternal physical activity on in vitro fertilization outcomes: a systematic review and meta-analysis

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