Fertility preservation strategies for cancerous women: An updated review

Anbari, Fatemeh; Khalili, Mohammad Ali; Mahaldashtian, Maryam; Ahmadi, Alireza; Palmerini, Maria Grazia

doi:10.4274/tjod.galenos.2022.42272

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…OTC and subsequent ovarian tissue transplantation (OTT) also offer benefits including protection against early menopause and long-term fertility preservation. It could be applied to women at a suitable age with adequate ovarian reserve, as well as patients who cannot delay their cancer treatment due to controlled ovarian stimulation (5). Vitrification is one of the proposed methods that has been recently noticed as an optimal technique for preserving ovarian tissue (2,6).…”

Section: Introductionmentioning

confidence: 99%

The report of ovarian tissue transplant in Iran: A case report

Anbari,

Khalili,

Vatanparast

et al. 2024

IJRM

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Background: Cancer treatments such as chemotherapy and radiotherapy increase the chance of ovarian failure. Ovarian tissue transplantation (OTT) is a viable option for fertility preservation in these cases. We aim to report ovarian transplantation in a leukemia case undergoing the vitrification method. Case Presentation: The case was a 28-yr-old female in Research and Clinical Center for Infertility, Yazd, Iran who was suffering from leukemia. Ovarian biopsy was performed by laparoscopy surgery and transported to cryopreservation lab at 4°C for 1–2 hr. The ovarian cortex was removed from the medulla, and ovarian strips were cryopreserved by vitrification. This procedure used the equilibration and vitrification solutions including medium 199 supplemented with 20% serum, and ethylene glycol and dimethyl sulfoxide with concentrations of 7.5% and 20%, respectively. Before doing OTT, we assessed the tissue viability and follicular count by chick embryo chorioallantoic membranes and histologic survey, respectively. OTT was done after complete remission, following warmed tissue sutured together and transplanted on the residual medulla on the right side. On the left side, the ovary was removed completely; however, 2 strips were put on the peritoneal pocket. Anti-Müllerian hormone, follicle-stimulating hormone, and luteinizing hormone levels were 0.1 ng/mL, 36.5 mIU/mL, and 19.8 mIU/mL before OTT. During a 6-month follow-up, the anti-Müllerian hormone increased to 0.9, and then follicle-stimulating hormone and luteinizing hormone levels decreased dramatically until 17.47 mIU/mL and 6.71 mIU/mL, respectively. Also, the patient had 3 cycles of menstrual periods. Conclusion: We demonstrated an appropriate hormonal profile, and the restoration of the menstrual cycle might indicate a successful transplant. Further investigations are needed to achieve successful clinical outcomes. Key words: Cryopreservation, Tissue transplantation, Leukemia, Vitrification, Ovarian follicle.

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Section: Introductionmentioning

confidence: 99%

The report of ovarian tissue transplant in Iran: A case report

Anbari,

Khalili,

Vatanparast

et al. 2024

IJRM

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“…By breaking down each component, we hope to offer a comprehensive explanation of the phenomenon, illuminating both its potential advantages and the complex problems it poses. Addressing the mental health of the individuals involved requires an understanding of the factors that lead women to choose social egg freezing as well as the emotional effects of delayed parenthood [ 3 ]. To achieve a balance between personal preferences and social norms, it is important to thoroughly explore ethical issues related to autonomy, equality, and societal expectations [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Landscape of Social Egg Freezing: Navigating Medical Advancements, Ethical Dilemmas, and Societal Impacts

Lahoti,

Pajai,

Shegekar

et al. 2023

Cureus

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This narrative review article comprehensively explores the multifaceted landscape of social egg freezing, delving into its medical, ethical, societal, psychological, legal, and cultural dimensions. Oocyte cryopreservation, a developing procedure, gives women the chance to match their life goals with fertility goals. Informed decision-making, morally sound guidance, and open communication are all stressed by ethical considerations. Family planning practices, workplace cultures, and gender equality all have an impact on societal dynamics. The process's emotional toll and associated coping mechanisms are highlighted by psychological elements. Legal and policy frameworks need constant ethical reflection and understanding of the regulatory environment. Religious and cultural views highlight the variety of perspectives that influence attitudes toward this practice. For responsible practice to ensure individual liberty while navigating the evolving landscape of reproductive options, it is essential to comprehend how these aspects interact.

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“…FP methods include ovarian transposition, oocyte or embryo cryopreservation, and ovarian tissue cryopreservation (OTC) (Anbari et al, 2022). OTC is the only pre-treatment option currently available for FP in prepubescent and adult females who cannot undergo ovarian stimulation or a delay in oncological therapy (Handling et al, 2021;Herraiz and Cervello, 2020;Jing et al, 2021;Margita et al, 2022; International Society for Fertility Preservation-ESHRE-ASRM Expert Working Group, 2017; Practice Committee of American Society for Reproductive Medicine, 2014).…”

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confidence: 99%

Impacts of vitrification on the transcriptome of human ovarian tissue in patients with gynecological cancer

Huang

et al. 2023

Front. Genet.

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Objective: This study investigated the effects of a vitrification/warming procedure on the mRNA transcriptome of human ovarian tissues.Design: Human ovarian tissues were collected and processed through vitrification (T-group) and then subjected to RNA sequencing (RNA-seq) analysis, HE, TdT-mediated dUTP nick-end labeling (TUNEL), and real-time quantitative PCR, and the results were compared to those of the fresh group (CK).Results: A total of 12 patients, aged 15–36 years old, with a mean anti-Müllerian hormone level of 4.57 ± 3.31 ng/mL were enrolled in this study. According to the HE and TUNEL results, vitrification effectively preserved human ovarian tissue. A total of 452 significantly dysregulated genes (|log2FoldChange| > 1 and p < 0.05) were identified between the CK and T groups. Among these, 329 were upregulated and 123 were downregulated. A total of 372 genes were highly enriched for 43 pathways (p < 0.05), which were mainly related to systemic lupus erythematous, cytokine–cytokine receptor interaction, the TNF signaling pathway, and the MAPK signaling pathway. IL10, AQP7, CCL2, FSTL3, and IRF7 were significantly upregulated (p < 0.01), while IL1RN, FCGBP, VEGFA, ACTA2, and ASPN were significantly downregulated in the T-group (p < 0.05) compared to the CK group, which agreed with the results of the RNA-seq analysis.Conclusion: These results showed (for the first time to the authors’ knowledge) that vitrification can induce changes in mRNA expression in human ovarian tissues. Further molecular studies on human ovarian tissues are required to determine whether altered gene expression could result in any downstream consequences.

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Fertility preservation strategies for cancerous women: An updated review

Cited by 5 publications

References 71 publications

The report of ovarian tissue transplant in Iran: A case report

The report of ovarian tissue transplant in Iran: A case report

Exploring the Landscape of Social Egg Freezing: Navigating Medical Advancements, Ethical Dilemmas, and Societal Impacts

Impacts of vitrification on the transcriptome of human ovarian tissue in patients with gynecological cancer

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