Fertility Preservation in Reproductive Age Women with Cancer

Kovács, Péter

doi:10.1007/s13224-014-0626-0

Cited by 4 publications

(2 citation statements)

References 52 publications

(54 reference statements)

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“…Fertility medications do not seem to affect cancer risk in the offspring. There are options for fertility treatment for those who are diagnosed with or who have survived cancer but each case has to be assessed individually [59].…”

Section: Expert Commentarymentioning

confidence: 99%

Fertility medications and the risk of cancer

Kovács

2013

Expert Review of Endocrinology & Metabolism

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Cancer is among the leading causes of death in all age groups for both sexes. Cancer is the second leading cause of death in women and is responsible for 22.1% of mortality [1]. Breast, lung and colorectal cancers are the three most common malignancies in women. Cancers of the reproductive organs are among the most frequently diagnosed malignant diseases (breast cancer is the most common, uterine cancer is the fourth and ovarian cancer is the eighth most common) [2].Multiple factors play a role in the etiology of cancer (genetic, infectious, environmental, life style, hormonal, and so on). Certain types of cancers are more common among women (e.g., thyroid), which suggests a role for hormonal effects. Reproductive factors that are also closely associated with alterations in the hormonal balance are also well known to be associated with certain malignancies. The use of hormone products to manage infertility of different etiologies have been available for approximately 50 years. The peak incidence for cancers of the reproductive organs is the fifth to sixth decade of life and therefore most patients who were exposed to these medications have recently entered menopause, or will do so in the near future. Due to the recent trend of delaying childbearing, the number of couples seeking infertility care is continuously on the rise. This has led to increased utilization of infertility services. It is therefore very important to study any potential association between these medications and cancer.This review will summarize the findings of large, relevant case-control and cohort studies and reviews that explored the association between infertility, fertility medication use and the subsequent risk of developing cancer. Studies that were published between 1976 and 2012 were considered for the review. They were identified through searching PubMed and by checking the reference lists of the individual articles. Studies with relatively large sample size, long follow-up times, a clear description of how the cancer cases were identified and with the proper selection of controls were considered for this review. The following search terms were used: in vitro fertilization (IVF), infertility, subfertility, cancer, ovarian cancer, breast cancer, uterine cancer, thyroid cancer, childhood cancer, fertility medication and gonadotropin.In case-control studies, the cases are first identified based on preset criteria (i.e., those individuals who have the disorder, in this case cancer). Controls are selected to match the cases for personal, geographic, period of time characteristics and so on. Proper control selection is important to establish a relationship between the studied exposure (in this case, fertility medication use) and the disorder. In this case, the researcher looks backward to identify whether cases or controls differ regarding their exposure Cancer is among the leading causes of death, and malignant diseases of the female genital tract are among the most common sites. Reproductive factors that are also associated with infertili...

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Section: Expert Commentarymentioning

confidence: 99%

Fertility medications and the risk of cancer

Kovács

2013

Expert Review of Endocrinology & Metabolism

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“…For example, the five year-survival rate of breast cancer including all cancer stages has reached 89% [ 1 ]. The number of young cancer survivors among women diagnosed with cancer has been continuously increasing [ 2 ]. As a result, quality-of-life issues, including future pregnancies after cancer treatment, have gained significant importance in cancer care.…”

Section: Introductionmentioning

confidence: 99%

Fertility preservation in women with cancer

Lee

Song

et al. 2012

Clin Exp Reprod Med

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Fertility preservation (FP) is an effort to retain the fertility of cancer patients, and as an emerging discipline, it plays a central role in cancer care. Because of improvement in diagnostic and therapeutic strategies, an increasingly large number of patients are surviving with cancer. FP specialists should make an effort to spread the significance of FP among reproductive women with cancer and provide appropriate education both for associated physicians and for cancer patients who wish to preserve their fertility. Physicians who take part in the initial diagnosis and management of cancer should consider the importance of early referral of young cancer patients to FP specialists and take care of those patients by providing timely information and appropriate counseling. Individualized treatment strategies should be delivered depending on the patient's situation with appropriate team approach.

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Onkologie und Versorgung in Fach- und Publikumsmedien

2015

Onkologe

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Fertility Preservation in Reproductive Age Women with Cancer

Cited by 4 publications

References 52 publications

Fertility medications and the risk of cancer

Fertility medications and the risk of cancer

Fertility preservation in women with cancer

Onkologie und Versorgung in Fach- und Publikumsmedien

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