Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan

Furui, Tatsuro; Takai, Yasushi; Kimura, Fuminori; Kitajima, Michio; Nakatsuka, Mikiya; Morishige, Ken Ichiro; Higuchi, Akiko; Shimizu, Chikako; Ozawa, Miwa; Ohara, Akira; Tatara, Ryohei; Nakamura, Toshio; Horibe, Keizo; Suzuki, Nao

doi:10.1002/rmb2.12256

Cited by 24 publications

(16 citation statements)

References 15 publications

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“…Japan is also one of advanced country which has guideline of FP treatment collaborate JSFP with JSCO (Japan Society of Clinical Oncology) (24). JSFP may start a registration system for FP treatment within 1 year to understand the present status of FP in Japan based on national survey for FP (25, 26). However, FP for C-A patients is not as common as FP for adult cancer patients (27).…”

Section: Discussionmentioning

confidence: 99%

Fertility Preservation for Child and Adolescent Cancer Patients in Asian Countries

et al. 2019

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Background: At present, fertility is one of the main concerns of young cancer patients. Following this trend, “fertility preservation (FP)” has been established and has become a new field of reproductive medicine. However, FP for child and adolescent (C-A) cancer patients is still developing, even in advanced countries. The aim of the present study was to assess the barriers to FP for C-A patients by investigating the current status of FP for C-A patients in Asian countries, which just have started FP activities.Method: A questionnaire survey of founding members of the Asian Society for Fertility Preservation (ASFP) was conducted in November 2018.Main findings: Of the 14 countries, 11 country representatives replied to this survey. FP for C-A patients is still developing in Asian countries, even in Australia, Japan, and Korea, which have organizations or academic societies specialized for FP. In all countries that replied to the present survey, the patients can receive embryo cryopreservation (EC), oocyte cryopreservation (OC), and sperm cryopreservation (SC) as FP. Compared with ovarian tissue cryopreservation (OTC), testicular tissue cryopreservation (TTC) is an uncommon FP treatment because of its still extremely experimental status (7 of 11 countries provide it). Most Asian countries can provide FP for C-A patients in terms of medical technology, but most have factors inhibiting to promote FP for C-A patients, due to lack of sufficient experience and an established system promoting FP for C-A patients. “Don't know how to provide FP treatment for C-A” is a major barrier. Also, low recognition in society and among medical staff is still a particularly major issue. There is also a problem with cooperative frameworks with pediatric departments. To achieve high-quality FP for C-A patients, a multidisciplinary approach is vital, but, according to the present study, few paramedical staff can participate in FP for C-A patients in Asia. Only Australia and Korea provide FP information by video and specific resources.Conclusion: The present study demonstrated the developing status of FP for C-A patients in Asian countries. More intensive consideration and discussion are needed to provide FP in Asian societies based on the local cultural and religious needs of patients.

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Section: Discussionmentioning

confidence: 99%

Fertility Preservation for Child and Adolescent Cancer Patients in Asian Countries

et al. 2019

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“…Our findings were consistent with a recent survey of 167 female adolescents and young adults from Japan that demonstrated that only 48% of patients with nonbreast and nonhematologic malignancies had received information about the association of cancer therapy with reproductive organ health. 13 This finding suggests that there exists a need both in the US and elsewhere to identify strategies to increase fertility education and indicated referrals to fertility specialists for adult patients with newly diagnosed cancers.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Reported Fertility Preservation Counseling Before Chemotherapy Using the Quality Oncology Practice Initiative Survey

et al. 2020

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IMPORTANCE The opportunity to discuss fertility preservation is essential for patients of reproductive age with newly diagnosed cancer before the initiation of treatment. OBJECTIVE To identify factors associated with fertility preservation counseling among patients of reproductive age before initiating chemotherapy. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study used data obtained from the American Society of Clinical Oncology (ASCO) Quality Oncology Practice Initiative, an oncologist-led quality assessment program that surveys approximately 400 oncology practices biannually, from January, 2015, to June, 2019. MAIN OUTCOMES AND MEASURES The primary outcome was whether reproductive risks were discussed before initiation of chemotherapy. Multivariate logistic regression was performed to identify factors associated with fertility preservation counseling, controlling for age, sex, race/ ethnicity, cancer type, year of study, region, clinic type (academic vs private), annual clinic volume, and rates of insurance coverage. RESULTS Among the 6976 patients of reproductive age (3571 men [51%]; mean (SD) age, 42.5 [7.1] years), with reproductive age ranging from 18 to 40 years for 3405 women and from 18 to 50 years for 3571 men, clinics reported that 3036 of 6976 patients (44%) received counseling regarding the risk of infertility associated with chemotherapy. Women were more likely to be informed (1912 of 3405 [56%]) compared with men (1126 of 3571 [32%]) (P < .001). Factors associated with reduced likelihood of fertility risk discussion included male sex (odds ratio [OR], 0.73; 95% CI, 0.60-0.90), increasing age (OR, 0.93; 95% CI, 0.92-0.94), private practice setting (OR, 0.70; 95% CI, 0.53-0.93), and lack of multidisciplinary team planning (OR, 0.54; 95% CI, 0.41-0.70). Factors associated with increased likelihood of fertility risk discussion included having breast cancer (OR, 1.39; 95% CI,

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“…With the dramatic developments in cancer treatments, “cancer survivorship” is regarded as an important issue in cancer therapy. “Fertility” has been a particular concern among cancer survivors and medical practitioners . Furthermore, facilitation of pregnancy and delivery after cancer treatment is one solution to recovering the reduced birthrate of leading countries that have a low total fertility rate.…”

Section: Introductionmentioning

confidence: 99%

Current state and future possibilities of ovarian tissue transplantation

Takae

Suzuki

2019

Reprod Medicine & Biology

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Background As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment for girls with malignant disease. Indeed, OTC requires ovarian tissue transplantation (OTT) for conception. As for OTC, there is room to investigate OTT. The present review focused on the current state and progress of OTT. Method The literature regarding OTT, which is currently under development, was reviewed. Main findings To improve the outcome of OTT, both efficacy and safety are important. Good surgical technique and the optimal site are important surgical factors, with orthotopic transplantation increasing. Treatment of growth factors, gonadotropins, antioxidants, apoptosis suppression factors, and cell therapy may improve the efficacy of OTT by inducing neo‐angiogenesis and preventing damage. Artificial ovaries, complete in vitro primordial follicle culture technique, and non‐invasive ovarian imaging techniques, such as optical coherence tomography, to select the best ovarian tissue are future possibilities. Conclusion Improving neo‐angiogenesis and preventing damage with optimization, as well as investigation of future techniques, may bring us to the next stage of a fertility preservation strategy.

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Fertility preservation in adolescent and young adult cancer patients: From a part of a national survey on oncofertility in Japan

Cited by 24 publications

References 15 publications

Fertility Preservation for Child and Adolescent Cancer Patients in Asian Countries

Fertility Preservation for Child and Adolescent Cancer Patients in Asian Countries

Evaluation of Reported Fertility Preservation Counseling Before Chemotherapy Using the Quality Oncology Practice Initiative Survey

Current state and future possibilities of ovarian tissue transplantation

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