Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress

Parraguez, Vı́ctor H.; Urquieta, Bessie; Pérez, Laura Crespo; Castellaro, Giorgio; Reyes, M. De los; Torres-Rovira, Laura; Aguado‐Martínez, Adriana; Astiz, Susana; González-Bulnes, Antonio

doi:10.1186/1477-7827-11-24

Cited by 38 publications

(32 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adverse effects of hypoxia when not adequately met by physiological coping mechanisms can also be seen in reproduction and fertility traits in sheep, e.g. reduced intrauterine growth (Parraguez et al 2005) and impaired development and function of the corpus luteum (Parraguez et al 2013).…”

Section: Effects Of High Altitude On the Mammalian Body And Physiologmentioning

confidence: 99%

Selection signatures for high‐altitude adaptation in ruminants

Friedrich

Wiener

2020

Animal Genetics

View full text Add to dashboard Cite

Summary High‐altitude areas are important socio‐economical habitats with ruminants serving as a major source of food and commodities for humans. Living at high altitude, however, is extremely challenging, predominantly due to the exposure to hypoxic conditions, but also because of cold temperatures and limited feed for livestock. To survive in high‐altitude environments over the long term, ruminants have evolved adaptation strategies, e.g. physiological and morphological modifications, which allow them to cope with these harsh conditions. Identification of such selection signatures in ruminants may contribute to more informed breeding decisions, and thus improved productivity. Moreover, studying the genetic background of altitude adaptation in ruminants provides insights into a common molecular basis across species and thus a better understanding of the physiological basis of this adaptation. In this paper, we review the major effects of high altitude on the mammalian body and highlight some of the most important short‐term (coping) and genetically evolved (adaptation) physiological modifications. We then discuss the genetic architecture of altitude adaptation and target genes that show evidence of being under selection based on recent studies in various species, with a focus on ruminants. The yak is presented as an interesting native species that has adapted to the high‐altitude regions of Tibet. Finally, we conclude with implications and challenges of selection signature studies on altitude adaptation in general. We found that the number of studies on genetic mechanisms that enable altitude adaptation in ruminants is growing, with a strong focus on identifying selection signatures, and hypothesise that the investigation of genetic data from multiple species and regions will contribute greatly to the understanding of the genetic basis of altitude adaptation.

show abstract

Section: Effects Of High Altitude On the Mammalian Body And Physiologmentioning

confidence: 99%

Selection signatures for high‐altitude adaptation in ruminants

Friedrich

Wiener

2020

Animal Genetics

View full text Add to dashboard Cite

show abstract

“…4 When the PAO 2 of air is less than 8 kPa (60 mmHg), the arterial oxygen content (CaO 2 ) and the arterial oxygen saturation (SaO 2 ) can significantly decrease and cause hypotonic hypoxemia (low arterial oxygen pressure, low saturation of hemoglobin by oxygen, and high hematocrit and hemoglobin concentrations). 5 This most commonly occurs at high altitudes because both the atmospheric pressure and the PAO 2 of air decreases with increased elevation. Generally, hypoxemia occurs in humans at an altitude of 2000 m or above.…”

Section: Introductionmentioning

confidence: 99%

Oxygen enrichment and its application to life support systems for workers in high-altitude areas

Liu

2014

International Journal of Occupational and Environmental Health

View full text Add to dashboard Cite

Background: Workers coming from lowland regions are at risk of developing acute mountain sickness (AMS) when working in low oxygen high-altitude areas. Objectives: The aim of this study was to improve the conditions that lead to hypoxia and ensure the safety of the high-altitude workers. We analyzed the influence of low atmospheric pressure on the oxygen enrichment process in high-altitude areas using an engineering method called low-pressure swing adsorption (LPSA). Methods: Fourteen male subjects were screened and divided into three groups by type of oxygen supply system used: (1) oxygen cylinder group; (2) LPSA oxygen dispersal group; and (3) control group. These tests included arterial oxygen saturation (SaO 2 ), pulse rate (PR), breaths per minute (BPM), and blood pressure (BP). Results:The results showed that after supplying oxygen using the LPSA method at the tunnel face, the SaO 2 of workers increased; the incidence of acute mountain sickness, PR, and BPM significantly decreased. Conclusions: The LPSA life support system was found to be a simple, convenient, efficient, reliable, and applicable approach to ensure proper working conditions at construction sites in high-altitude areas.

show abstract

“…Such hypothesis is supported by a recent study in which exposure of sheep to high‐altitude hypobaric hypoxia, both during short and long time, negatively affected corpus luteum development and function (Parraguez et al. ). The quality of corpora lutea has been classically linked to both ovarian causes (quality of the previous preovulatory follicle; Keisler and Keisler ) and/or systemic causes (inadequate LH secretion, which is necessary for the final maturation of the preovulatory follicles and, subsequently, adequate development of the corpora lutea; Adams ; Campbell et al.…”

Section: Introductionmentioning

confidence: 71%

“…Failures in LH pulsatility may not be of enough importance for avoiding ovulation and early luteogenesis, but may affect subsequent corpora lutea development, as it was found in a previous study (Parraguez et al. ), and/or may lead to oocyte maturation weakness and to limitations in the competence of these oocytes for fertilization and subsequent embryo development (Oussaid et al. ; Cognié et al.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Fertility of a High‐Altitude Sheep Model is Compromised by Deficiencies in Both Preovulatory Follicle Development and Plasma LH Availability

Parraguez

Diaz

Cofré

et al. 2014

Reprod Domestic Animals

View full text Add to dashboard Cite

At high altitude, hypoxia and/or oxidative stress may compromise fertility. This study tested the relative effect of short- or long-term exposure to high-altitude hypobaric hypoxia and oxidative stress in sheep on preovulatory follicle dynamics and gonadotrophin secretion. Thus, growth dynamics, stereidogenic function and competence to ovulate of preovulatory follicles, as well as FSH and LH availability throughout the entire oestrous cycle, were compared among sheep native from low and high altitude, and sheep newcomers to high altitude. The results indicates that short-term exposure in sheep newcomers to high altitude has a deleterious effect on both the ovarian function (affecting preovulatory follicular development) and the pituitary function (diminishing plasma LH availability). On the other hand, there were no detected differences in the preovulatory follicular development in sheep adapted to high altitude for generations and, conversely, LH secretion was increased, which suggests an adaptive mechanism. The treatment with antioxidant agents during a relative short period for the time of folliculogenesis (approximately 1 month and a half) changed substantially the development of preovulatory follicles in short-term exposed sheep to similar patterns than in sheep native and living to both high and low altitude. These results highlight the role of oxidative stress in the detriment of the reproductive function in individuals recently exposed to high-altitude hypoxic environment.

show abstract

Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress

Cited by 38 publications

References 31 publications

Selection signatures for high‐altitude adaptation in ruminants

Selection signatures for high‐altitude adaptation in ruminants

Oxygen enrichment and its application to life support systems for workers in high-altitude areas

Fertility of a High‐Altitude Sheep Model is Compromised by Deficiencies in Both Preovulatory Follicle Development and Plasma LH Availability

Contact Info

Product

Resources

About