Fertility and parenthood issues in young female cancer patients—a systematic review

Sobota, Aleksandra; Ozakinci, Gözde

doi:10.1007/s11764-014-0388-9

Cited by 37 publications

(48 citation statements)

References 90 publications

(227 reference statements)

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“…Recent reviews highlight the benefits of oncofertility interventions in improving quality of life and lowering dissatisfaction in survivorship . Simply undergoing fertility preservation improves the subjective experience of cancer treatments .…”

Section: Introductionmentioning

confidence: 99%

A systematic review of patient oncofertility support needs in reproductive cancer patients aged 14 to 45 years of age

et al. 2017

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Section: Introductionmentioning

confidence: 99%

A systematic review of patient oncofertility support needs in reproductive cancer patients aged 14 to 45 years of age

et al. 2017

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“…Current treatment guidelines advocate for all cancer patients of reproductive age to be informed of the impact of cancer treatment on their fertility in a timely manner, alongside the referral to fertility specialist services to reduce significant later life impacts and meet the support needs of cancer patients and survivors. Further, there is a growing consensus that fertility should be discussed with all cancer patients at the time of diagnosis, prior to commencing cancer treatment . In addition, to allow these cancer patients the opportunity to have a biological child in the future, patients should have the opportunity to undertake fertility preservation .…”

Section: Introductionmentioning

confidence: 99%

Clinician provision of oncofertility support in cancer patients of a reproductive age: A systematic review

et al. 2017

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Oncofertility support is often not delivered to the standard of current guidelines, with many clinicians not providing the recommended care to all eligible patients, and as such many patients may lack the oncofertility support that they require. The implementation of a clear procedural process would assist clinicians in the provision of oncofertility support for cancer patients of reproductive age.

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“…Although relatively few cancer patients currently experience an abnormal menstrual cycle after cancer therapy, they are nonetheless at risk of losing fertility [13,14]. Evidence shows that, for young women, the ability to have children is an important and determinant factor of their quality of life after the end of cancer treatment [15]. The results of this study suggest that after a minimal follow up of 3 years, only a low percentage of patients will actively attempt to obtain pregnancy, mainly because of persistent or progressive tumoral disease and because of personal choices.…”

Section: Discussionmentioning

confidence: 99%

“…This paradox illustrates the uncertainty around fertility preservation before cancer treatment and both desires and attempts to become pregnant after cancer treatment. Even though many women choose fertility preservation before cancer treatment, cancer therapy has a major impact on decisions related to pregnancy attempts after cancer treatment, and both increased and decreased desire to have children after cancer therapy have been reported, and are related to the success and efficient use of fertility preservation [15].…”

Section: Discussionmentioning

confidence: 99%

A Real-Life Analysis of Reproductive Outcome after Fertility Preservation in Female Cancer Patients

Hulsbosch¹,

Koskas²,

Tomassetti³

et al. 2017

Gynecol Obstet Invest

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Background: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. Patients and Methods: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included. After a minimal follow-up of 3 years, pregnancy wish, pregnancy attempts and fertility outcome were assessed during a dedicated consultation or during a telephone interview. Results: A total of 159 patients received fertility preservation including hormonal protection with gonadotropin-releasing hormone agonist (n = 93, 58.5%), ovarian tissue cryopreservation (n = 44, 27.7%), and combined hormonal protection and ovarian tissue cryopreservation (n = 22, 13.8%). Among the 91 (57.2%) patients in remission after a mean follow-up of 61.5 months, 29 (31.9%) women actively attempted pregnancy. Patients who had received ovarian cryopreservation were more likely to attempt pregnancy (18/66) than those who only received hormonal protection (11/93, p = 0.02). Out of the 29 women who attempted pregnancy, 16 (55.2%) became pregnant, and most of them conceived spontaneously (87.5%, 14/16). Out of the 13 women who did not become pregnant, 1 patient adopted a child and 12 patients still wanted to become pregnant, including 1 patient who underwent a transplantation of her cryopreserved ovarian tissue without success. Conclusion: In one of the first studies reporting real-life experience in centers for fertility preservation, we found that, within 5 years following the end of cancer treatment, only one third of patients in remission attempted to become pregnant, with a pregnancy rate of 55%, mostly after spontaneous conception.

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Fertility and parenthood issues in young female cancer patients—a systematic review

Abstract: The existing literature gives preliminary insight into the importance of fertility for young women diagnosed with cancer. However, more research is needed in order to offer patients comprehensive care.

Cited by 37 publications

References 90 publications

A systematic review of patient oncofertility support needs in reproductive cancer patients aged 14 to 45 years of age

A systematic review of patient oncofertility support needs in reproductive cancer patients aged 14 to 45 years of age

Clinician provision of oncofertility support in cancer patients of a reproductive age: A systematic review

A Real-Life Analysis of Reproductive Outcome after Fertility Preservation in Female Cancer Patients

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