Fertility after bilateral uterine artery embolization in a sheep model

Recanalization and particle exclusion after embolization of uterine arteries in sheep: a long-term study

“…In cases of unsuccessful inseminations, ewes could be inseminated during two other scheduled trials. The details and results on fertility were reported elsewhere (15).…”

“…We recently demonstrated that UAE with PVA and TGMS will have a different impact on fertility in sheep (15). The PVA particles lead to a more drastic decrease of ewe fertility than TGMS particles.…”

“…The present histologic study examined the recanalization in vessels with microspheres and the transvascular migration of PVA particles and TGMS in the long term after embolization with the objective of finding an explanation for the differences observed between the two embolic agents in terms of fertility of ewes and intrauterine growth of fetuses (15). We have examined the long-term recanalization of uterine vessels and transvascular migration of PVA particles (600-1000 mm) and calibrated 700-900 mm TGMS in specimens of uterus in our previous fertility study in the sheep (15).…”

“…We have examined the long-term recanalization of uterine vessels and transvascular migration of PVA particles (600-1000 mm) and calibrated 700-900 mm TGMS in specimens of uterus in our previous fertility study in the sheep (15). Here, we compare [1] the site of occlusion (more or less distal) of both embolic agents in the specimens, [2] the rate of recanalization of vessels, and [3] the rate of transvascular migration (exclusion) of the two embolic agents.…”

A Preclinical Study of the Safety and Efficacy of Occlusin™ 500 Artificial Embolization Device in Sheep

“…This would be a very desirable feature if future pregnancy is considered. Laurent et al [5] hypothesized that devascularization of the uterine tissue post-UAE could affect all steps of pregnancy: from conception to delivery. There are other instances where a temporary occluding agent would be desirable: for the treatment of gastrointestinal hemorrhage; solid organ injuries, such as splenic embolization; and in tumor embolization, where repeat procedures are required.…”