Ferrous Oxide Nanoparticles Induced Abnormal Cardiac Development in Zebrafish Through Hypoxia and Ferroptosis

Zheng, Naying; Chen, X; Zhan, Reggie; Liao, Tingting; Shi, Yanyun; Sun, Xiaolian; Chen, Shuzhen; Zuo, Zhenghong

doi:10.1007/s40242-023-3055-8

Cited by 1 publication

(1 citation statement)

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“…The iron oxide, which is more commonly known as magnetite (Fe 3 O 4 ) or maghemite (γ-Fe 2 O 3 ), forms the core of these nanoparticles, with a radius varying from 5 to 15 nm. Since iron oxide is naturally hydrophobic, the nanoparticles are typically altered by adding an external coating made of a biocompatible hydrophilic polymer, like polyethylene glycol or dextran [47]. This coating is necessary to stop the nanoparticles from opsonizing or binding with plasma proteins, which would otherwise inevitably happen in the bloodstream [48].…”

Section: Various Iron Oxide-based Nanoparticlesmentioning

confidence: 99%

Metal-Based Nanoparticles for Cardiovascular Diseases

Scafa Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

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Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. While there are many therapeutic alternatives available for the management of CVDs, the majority of classic therapeutic strategies were found to be ineffective at stopping or significantly/additionally slowing the progression of these diseases, or they had unfavorable side effects. Numerous metal-based nanoparticles (NPs) have been created to overcome these limitations, demonstrating encouraging possibilities in the treatment of CVDs due to advancements in nanotechnology. Metallic nanomaterials, including gold, silver, and iron, come in various shapes, sizes, and geometries. Metallic NPs are generally smaller and have more specialized physical, chemical, and biological properties. Metal-based NPs may come in various forms, such as nanoshells, nanorods, and nanospheres, and they have been studied the most. Massive potential applications for these metal nanomaterial structures include supporting molecular imaging, serving as drug delivery systems, enhancing radiation-based anticancer therapy, supplying photothermal transforming effects for thermal therapy, and being compounds with bactericidal, fungicidal, and antiviral qualities that may be helpful for cardiovascular diseases. In this context, the present paper aims to review the applications of relevant metal and metal oxide nanoparticles in CVDs, creating an up-to-date framework that aids researchers in developing more efficient treatment strategies.

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Section: Various Iron Oxide-based Nanoparticlesmentioning

confidence: 99%