Ferrous ions doped calcium carbonate nanoparticles potentiate chemotherapy by inducing ferroptosis

The application of nanoparticles based on ferroptosis in cancer therapy

“…125,126 Therefore, in this section, we will summarize some nanoparticles of ferroptosis in combination with other therapeutic approaches for cancer treatment. These combination therapies mainly include ferroptosis in combination with chemotherapy, 127 ferroptosis in combination with PDT or PTT, 128,129 ferroptosis in combination with immunotherapy, 130 ferroptosis in combination with gene therapy, 131 and with other therapies. 132 The combination of ferroptosis with different cancer therapies may spark more investigations.…”

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

“…Those advantages facilitate the delivery of small ferroptosis inducers with more safety and efficiency. What is more important, the release of transition metal elements from the metal-based nanocomplexes own the ability to catalyze H 2 O 2 to high toxic •OH and boost ferroptosis [ 159 , 160 ]. Here, we chose phenylboronate ester bonds (PBE) and metal–polyphenol complexes as representative examples to illustrate the application of those acid-responsive nanosystems induced ferroptosis in tumor therapy.…”

Facile Synthesis of Basic Copper Carbonate Nanosheets for Photoacoustic Imaging-Guided Tumor Apoptosis and Ferroptosis and the Extension Exploration of the Synthesis Method

“…Malignant tumors have been recognized as a severe threat to human health because they feature high lethality and low curability. , The rapid proliferation of tumor cells creates a special tumor microenvironment (TME), such as over-expressed glutathione (GSH), hydrogen peroxide (H 2 O 2 ), acidic conditions, and up-regulated glucose consumption. − Nanomaterials with TME-responsive capacity are candidates of great promise for tumor theranostics, which have been extensively explored from various aspects. Among the newly developed responsive nanomaterials, carbonates are attracting increasing attention due to their good biocompatibility, biodegradability, and pH sensitivity. − For example, the well-explored calcium carbonate (CaCO 3 ) nanomaterials exhibit significant potential in drug delivery and could induce cell apoptosis by causing calcium overload. − However, the majority of carbonate nanomaterials are spherical in shape, − showing limited drug loading capacity and compromised tumor theranostics performance.…”