Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma: A Review

Abstract

Introduction: Hepatocellular carcinoma (HCC) is a liver cancer. In contrast, ferroptosis is a novel iron-dependent and ROS reliant type of cell death that is observed under various disease conditions.Methods and analysis: RNA sequencing data from HCC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Ferroptosis-related long non-coding RNAs (lncRNAs) were screened by Pearson correlation analysis. Patients were randomized into training or testing sets in a 1:1 ratio. They were constructed in the training set using univariate-Lasso and multivariate Cox regression analysis and further tested for prognostic values in the testing set. Four lncRNAs were identified. Kaplan-Meier analysis showed that patients in the high-risk group had a worse prognosis than those in the low-risk group. Following differentially expressed genes analysis of these two groups. Functional analysis showed association with oxidative stress response. Cox regression analyses showed that risk score was an independent prognostic indicator. Receiver operating characteristic curve (ROC) and decision curve analysis demonstrated the accuracy of prediction. Four ferroptosis-related lncRNAs based on differential expression of HCC were screened by bioinformatic methods to construct a prognostic risk model and accurately predict the prognosis of HCC patients. Four lncRNAs may have a potential role in the anti-tumor immune process and serve as therapeutic targets for HCC. To lay the foundation for subsequent studies.Abbreviations: CC = cellulose component, DCA = decision curve analysis, DEG = differentially expressed gene, FC = fold change, FDR = false discovery rate, lncRNA = long non-coding RNA, GO = gene ontology, HCC = hepatocellular carcinoma, KEGG = Kyoto Encyclopedia of Genes and Genomes, Lasso = least absolute shrinkage and selection operator, ROC = receiver operating characteristic curve, TCGA = The Cancer Genome Atlas.

A New Prognostic Model of Oxidative-Stress-Related lncRNAs in Hepatocellular Carcinoma & Its Validation In Vitro

“…Ferroptosis [31], immune related [32], etc. There have also been related experiments exploring the relationship between oxidative stress and HCC [33].…”

“…Firstly, we used R and statistical analysis to develop prognostic risk models for eight OS-lncRNAs using a public database. Although these methods have been extensively studied and proven [30][31][32][33], and some of the eight types of OS-lncRNAs have been studied to some extent [35][36][37][38][39][40][41]. In addition, in-depth research is needed, including their functions and molecular mechanisms.…”

Clinical Significance of Non-Coding RNA Regulation of Programmed Cell Death in Hepatocellular Carcinoma

“…Several survival prognostic models are currently constructed via PCD-related lncRNAs from online databases. These provide new insights into exploring the correlation between HCC and PCD and assessing the prognosis of HCC [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] ( Figure 2 ).…”