Ferroptosis in tumor immunity and therapy

Gong, Chuandong; Ji, Qiankun; Wu, Miao-Jing; Tu, Zewei; Lei, Kunjian; Luo, Mingzhang; Liu, Junzhe; Li, Lin; Li, Kuangxun; Li, Jingying; Huang, Kai; Zhu, Xiang Yang

doi:10.1111/jcmm.17529

Cited by 23 publications

(12 citation statements)

References 164 publications

(379 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that ferroptosis is strictly correlated with the tumor immune microenvironment [56][57][58][59][60]. Weimin Wang et al [61] explored that activating CD8+ T cell increases particular lipid peroxidation in tumor cells, facilitating the process of ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

Construction of a ferroptosis-related lncRNA signature for predicting prognosis, immune response and drug sensitivity in cervical squamous cell carcinoma and endocervical adenocarcinoma

2023

EJGO

View full text Add to dashboard Cite

Ferroptosis, a recently identified cell death mode, has been shown to play critical roles in several malignant tumors. Long non-coding RNAs (lncRNAs) have been reported to modulate ferroptosis, thereby affecting the growth and prognosis of cancers. However, the association between lncRNA and ferroptosis in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) remains unclear. The aim of this study was to identify ferroptosis-related lncRNAs (FRLs) associated with CESC prognosis and investigate their interaction with tumor immune response. R software and Perl were used to screen for aberrant expressed FRLs associated with CESC patient prognosis from The Cancer Genome Atlas (TCGA) database, including AP003774.2, SOX21 antisense divergent transcript 1 (SOX21-AS1), myocardial infarction associated transcript (MIAT), RUSC1 antisense RNA 1 (RUSC1-AS1), AC004847.1, AC009097.2, MIR100 host gene (MIR100HG), AC083799.1, long intergenic non-protein coding RNA 958 (LINC00958), AC009065.8 and AC131159.1. A risk score was calculated for each CESC patient individual according to the expression levels of 11 FRLs, based on which a prognostic model was built. Kaplan-Meier (K-M) survival curve analysis and Receiver Operating Characteristic (ROC) curve assessment were conducted to determine the predictive accuracy of the prognostic model. Lastly, the R software and CIBERSORT were employed to examine the differences in immune cell infiltration, immune checkpoint and drug sensitivity between the two subgroups. The 11 FRLs were used to construct a prognostic model that classified CESC patients into a high-or low-risk group. The FRL-based model was found to outperform traditional clinicopathological features in predicting CESC patient survival. Significant variations existed across subgroups in immune cell infiltration, immunological function, overall survival (OS), and inhibitory concentrations (IC50 values). Our findings provide novel insights into the role of FRLs in CESC and present a personalized predictive tool for determining patient prognosis, immune response and drug sensitivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Construction of a ferroptosis-related lncRNA signature for predicting prognosis, immune response and drug sensitivity in cervical squamous cell carcinoma and endocervical adenocarcinoma

2023

EJGO

View full text Add to dashboard Cite

show abstract

“…A mounting number of studies have reported that macrophages in the TME can undergo reception and integration of signals from the environment, communicate at the cell‐to‐cell level and successfully interconvert between different polarization states. 93 Following this, macrophages of different polarization types remodel the tumour immune microenvironment from different perspectives. Iron‐dead tumour cells release oxidized lipids, eicosanoids (5‐HETE, 11‐HETE and 15‐HETE), prostaglandins (PEG) and DAMPs as signalling messengers interacting with other components in the TME.…”

Section: Non‐apoptotic Rcd Mediates Time...mentioning

confidence: 99%

Section: Non‐apoptotic Rcd Mediates Time Reprogramming Of Macrophagesmentioning

confidence: 99%

Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages

Sun,

Zhan,

et al. 2024

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

Tumour immune microenvironment (TIME) plays an indispensable role in tumour progression, and tumour‐associated macrophages (TAMs) are the most abundant immune cells in TIME. Non‐apoptotic regulated cell death (RCD) can avoid the influence of tumour apoptosis resistance on anti‐tumour immune response. Specifically, autophagy, ferroptosis, pyroptosis and necroptosis mediate the crosstalk between TAMs and tumour cells in TIME, thus reprogram TIME and affect the progress of tumour. In addition, although some achievements have been made in immune checkpoint inhibitors (ICIs), there is still defect that ICIs are only effective for some people because non‐apoptotic RCD can bypass the apoptosis resistance of tumour. As a result, ICIs combined with targeting non‐apoptotic RCD may be a promising solution. In this paper, the basic molecular mechanism of non‐apoptotic RCD, the way in which non‐apoptotic RCD mediates crosstalk between TAMs and tumour cells to reprogram TIME, and the latest research progress in targeting non‐apoptotic RCD and ICIs are reviewed.

show abstract

“…According to their original study, comparing this iron-dependent cell death to other forms of RCD reveals distinct morphological, biochemical, and genetic differences [ 43 ]. The morphology of ferroptotic cells is characterized by smaller mitochondria, increased mitochondrial membrane density, decreased or absent cristae, outer mitochondrial membrane rupture, and the nuclei are normal in size without chromatin aggregation [ 44 ]. Accumulating studies have demonstrated that ferroptosis plays a crucial role in the development and progression of various diseases, including neurological disorders [ 45 ], cardiovascular diseases [ 46 ], ischemia-reperfusion injury [ 47 ], and cancer [ 48 ].…”

Section: Regulated Cell Death and Ferroptosismentioning

confidence: 99%

Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets

Nejadi Orang,

Abdoli Shadbad

2024

Cell Death Dis

View full text Add to dashboard Cite

As a newly identified regulated cell death, ferroptosis is a metabolically driven process that relies on iron and is associated with polyunsaturated fatty acyl peroxidation, elevated levels of reactive oxygen species (ROS), and mitochondrial damage. This distinct regulated cell death is dysregulated in various cancers; activating ferroptosis in malignant cells increases cancer immunotherapy and chemoradiotherapy responses across different malignancies. Over the last decade, accumulating research has provided evidence of cross-talk between non-coding RNAs (ncRNAs) and competing endogenous RNA (ceRNA) networks and highlighted their significance in developing and progressing malignancies. Aside from pharmaceutical agents to regulate ferroptosis, recent studies have shed light on the potential of restoring dysregulated ferroptosis-related ceRNA networks in cancer treatment. The present study provides a comprehensive and up-to-date review of the ferroptosis significance, ferroptosis pathways, the role of ferroptosis in cancer immunotherapy and chemoradiotherapy, ceRNA biogenesis, and ferroptosis-regulating ceRNA networks in different cancers. The provided insights can offer the authorship with state-of-the-art findings and future perspectives regarding the ferroptosis and ferroptosis-related ceRNA networks and their implication in the treatment and determining the prognosis of affected patients.

show abstract

Ferroptosis in tumor immunity and therapy

Cited by 23 publications

References 164 publications

Construction of a ferroptosis-related lncRNA signature for predicting prognosis, immune response and drug sensitivity in cervical squamous cell carcinoma and endocervical adenocarcinoma

Construction of a ferroptosis-related lncRNA signature for predicting prognosis, immune response and drug sensitivity in cervical squamous cell carcinoma and endocervical adenocarcinoma

Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages

Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets

Contact Info

Product

Resources

About