Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling
Xueyan Li,
Hailin Xu,
Xinying Zhao
et al.
Abstract:Background
Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that is implicated in myocardial diseases. Nevertheless, its role in the adverse cardiac effects of SiNPs has not been described.
Results
We first reported the induction of cardiomyocyte ferroptosis by SiNPs in both in vivo and in vitro. … Show more
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