Ferroptosis and its current progress in gastric cancer

Abstract

Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as the fifth most common malignant tumor worldwide. It is characterized by clinical features such as a tendency for metastasis and an unfavorable prognosis. Ferroptosis, a recently identified form of cell death, represents a novel mode of cellular demise that diverges from the traditional concepts of necrosis and apoptosis. Numerous studies have found that ferroptosis plays a significant role in the proliferation, metastasis, drug resistance, and microenvironment regulation within GC. This review summarizes the mechanism of ferroptosis and its role in the occurrence and development of GC cells. It provides examples demonstrating how various anti-tumor drugs can induce ferroptosis in GC cells. Additionally, it summarizes the potential application value of ferroptosis in the future treatment of GC.

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

“… Ning et al (2024) found that some plant extracts, exosomes, and plasmids exhibited the repair of radiation-induced hematopoietic and skin damage by inhibiting ferroptosis; Melatonin promoted the binding of Nrf2 and pyruvate kinase isoenzyme M2 (PKM2), which reduced iron concentration and inhibited ferroptosis to alleviate radiation-induced hippocampal neuronal death. Yue et al (2024) summarized that various anti-tumor drugs such as cisplatin, paclitaxel, capecitabine, apatinib and artemisinin could induce ferroptosis in gastric cancer (GC) cells. And even dexmedetomidine (DEX), levobupivacaine and other local anesthetics had potential value in the treatment of GC due to their ability in regulating ferroptosis and inhibiting GC ell proliferation.…”

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

“…Ferroptosis, a non-apoptotic type of RCD, exhibiting distinct morphological, biochemical, and genetic characteristics compared to other types of cell death, is modulated by multiple cellular metabolic processes such as iron handling, glycolipid metabolism, and redox homeostasis, along with various signaling pathways associated with disease progression [ 21 , 22 ]. Ferroptosis is characterized by the existence of diminished mitochondria and decreased mitochondrial cristae [ 23 ]. This mechanistic characteristic sets ferroptosis apart from other modes of RCD, which are governed by specific proteins that execute cell death [ 24 ].…”