Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma

Zhang, Gaosen; Fang, Yi; Li, Xiang; Zhang, Zhen

doi:10.3389/fonc.2022.947530

Cited by 4 publications

(6 citation statements)

References 127 publications

(145 reference statements)

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“…Two Ferroptosis-related genes, GPX4 and SLC7A11, were found to be upregulated in glioblastoma, which might be associated with the development and progression of glioblastoma [140,141]. The NRF2 pathway can inhibit glioblastoma iron death by enhancing the cystine/glutamate reverse transporter System-Xc [142].…”

Section: Glioblastomamentioning

confidence: 99%

Ferroptosis and cancer: interlinkages and potential applications

Hu¹,

Jiang²

2023

Clin. transl. rep.

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The buildup of lipid peroxides on the cell membrane is critical in the initiation of Ferroptosis, an iron-dependent form of controlled cell death. Ferroptosis is a type of cell death that varies from other types of cell death in both mechanics and morphology, and it holds significant promise for cancer therapy. As a result, there has been increasing interest in the cancer research community regarding the exploration and understanding of Ferroptosis in recent years. This review article aims to provide a solid theoretical foundation for the management of Ferroptosis in cancer. It accomplishes this by summarizing the processes that contribute to the development of Ferroptosis and outlining the underlying mechanisms of Ferroptosis in various types of tumors.

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Section: Glioblastomamentioning

confidence: 99%

Ferroptosis and cancer: interlinkages and potential applications

Hu¹,

Jiang²

2023

Clin. transl. rep.

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“…One potential target is the ROS-activated GCN2-eIF2α-ATF4-xCT pathway which leads to mitochondrial dysfunction and cisplatin resistance . Gliomas are the most common malignant tumors in central nervous system, which can easily become resistant to chemotherapy drugs during treatment, leading to a poor prognosis for patients . Ferroptosis-related regulators (e.g., GPX4, SLC7A11 and FSP1) are closely associated with the management of brain diseases including gliomas, and the induction of ferroptosis could also ameliorate the drug resistance of glioma to chemotherapeutic drugs …”

Section: Ferroptosis Inducers and Their Application In Cancer Therapymentioning

confidence: 99%

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

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Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation of iron metabolism and the accumulation of lipid peroxides. This nonapoptotic mode of cell death is implicated in various physiological and pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. This article focuses on ferroptosis-based therapeutic strategies for precision cancer treatment, covering the molecular mechanisms of ferroptosis, four major types of ferroptosis inducers and their inhibitory effects on diverse carcinomas, the detection of ferroptosis by fluorescent probes, and their implementation in image-guided therapy. These state-of-the-art tactics have manifested enhanced selectivity and efficacy against malignant carcinomas. Given that the administration of ferroptosis in cancer therapy is still at a burgeoning stage, some major challenges and future perspectives are discussed for the clinical translation of ferroptosis into precision cancer treatment. ■ SIGNIFICANCE • The potential of ferroptosis as an innovative strategy for precision cancer therapy is highlighted. • Recent advances are discussed from three perspectives: molecular mechanism and regulation, anti-cancer ferroptosis inducers, and ferroptosis probes for image-guided therapy. • The strengths and weaknesses of ferroptosis modulators and probes are analyzed in terms of current progress and technical barriers. • Future perspectives are emphasized to advance ferroptosis-based therapies toward clinical use for cancer treatment.

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“…Previous studies have reported that ferroptosis is reduced in tissues of glioma patients, and induction of ferroptosis is an effective strategy for treating glioma [16][17][18]. To further verify the role of ferroptosis in glioma, we retrieved the gene expression data of 19 ferroptosis suppressor genes with a confidence score of 3 or greater from the FerrDb website.…”

Section: The Relationship Between Cdca7 and Ferroptosis Suppressor Ge...mentioning

confidence: 99%

“…Both MYC and E2F1 are involved in regulating the occurrence and progression of ferroptosis [12][13][14], a newly discovered non-apoptotic cell death pattern characterized by an overwhelming iron-dependent accumulation of lethal lipid reactive oxygen species (ROS) [15]. While the dysregulation of ferroptosis is closely related to tumorigenesis and treatment, according to many previous studies, induction of ferroptosis was found to be effective in treating glioma [16][17][18]. Some studies also indicate that the over-expression of MYC and E2F1 has an inhibitory role in the occurrence of ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity

Wang

Zhao

Zhang

et al. 2023

Genes

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CDCA7 is a copy number amplification gene that promotes tumorigenesis. However, the clinical relevance and potential mechanisms of CDCA7 in glioma are unclear. CDCA7 expression level data were obtained from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases, and the enriched genes and related signaling pathways were explored. Data on genes in CDCA7-related signaling pathways and nine marker genes of ferroptosis were retrieved and a protein–protein interaction (PPI) network analysis was performed. The correlation of CDCA7 to ferroptosis and tumor infiltration of 22 kinds of human immune cells and the association between CDCA7 and immune checkpoint molecules were analyzed. CDCA7 was significantly increased in gliomas in comparison to healthy tissues. Gene Ontology (GO) and gene set enrichment analysis (GSEA) revealed the impact of CDCA7 expression on multiple biological processes and signaling pathways. CDCA7 may affect ferroptosis by interacting with genes in the cell cycle pathway and P53 pathway. The increase in CDCA7 was positively correlated with multiple ferroptosis suppressor genes and genes involved in tumor-infiltrating immune cells and immune checkpoint molecules in glioma. CDCA7 can be a new prognostic factor for glioma, which is closely related to ferroptosis, tumor immune cell infiltration, and immune checkpoint.

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Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma

Cited by 4 publications

References 127 publications

Ferroptosis and cancer: interlinkages and potential applications

Ferroptosis and cancer: interlinkages and potential applications

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity

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