Ferroptosis: A New Road towards Cancer Management

Abstract

Ferroptosis is a recently described programmed cell death mechanism that is characterized by the buildup of iron (Fe)-dependent lipid peroxides in cells and is morphologically, biochemically, and genetically distinct from other forms of cell death, having emerged to play an important role in cancer biology. Ferroptosis has significant importance during cancer treatment because of the combination of factors, including suppression of the glutathione peroxidase 4 (Gpx4), cysteine deficiency, and arachidonoyl (AA) peroxidation, which cause cells to undergo ferroptosis. However, the physiological significance of ferroptosis throughout development is still not fully understood. This current review is focused on the factors and molecular mechanisms with the diagrammatic illustrations of ferroptosis that have a role in the initiation and sensitivity of ferroptosis in various malignancies. This knowledge will open a new road for research in oncology and cancer management.

The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

“…Abnormal expression of cell cycle regulator proteins has also been implicated in neurodegenerative diseases. Additionally, increased levels of p53 in motor neurons of the spinal cord and motor cortex induce neuronal degeneration ( Bano et al, 2022 ).…”

Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2

“…Isoprenaline (ISO, 10 −5 M) did not affect these parameters in resting stage, but ISO reversed the effects of IL-1β and restored the survival of CHON-001 cells ( Figure 3A ). As we know, Bcl-2 is an anti-apoptotic protein often used as a marker to assess cellular apoptosis rate ( Chipuk et al, 2008 ; Bano et al, 2022 ). Incubation of CHON-001 cells with ISO significantly upregulated Bcl-2 gene expression ( Figure 3B ).…”

Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain

“…Berberine [ 33 ], icariin [ 34 ], and melatonin [ 35 ] are only a few of the medications that have been studied for this purpose. Many natural products are renowned for their wide range of therapeutic potential, and researchers have worked hard to develop such substances as important nutrients to treat a variety of illnesses [ 36 , 37 ]. Moreover, as pain is the protective mechanism alarming us about the proper measure to be taken for the initiated problem, so people utilize different approaches to relieving pain associated with chronic illness [ 38 ]…”