Ferrocene–indole hybrids for cancer and malaria therapy

Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

“…Ferrocene is the first known prototypical metallocene and has unique structure, robustness, and redox property. Its numerous derivatives have been endowed with broad range activities, such as anticancer [4][5][6], antimalarial [5,7], antibacterial [8], antiviral [9], anti-inflammatory [10] agents, and central nervous system active drugs [11]. Carboranes have been used as a source of neutron in boron neutron capture therapy (BCNT) for their high boron content and stability to catabolism [12].…”

Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities

“…As our interests lie also in the area of antiparasitic drugs [42,43] and since a few Pt(II) [44] and Pd(II) based complexes [45] with antimalarial activity (in the micromolar range) have been reported, we also tested the potential of the free ligands (1a-1c) and the complexes 2a-5c against the chloroquine-susceptible strain (3D7) and the chloroquine-resistant strain (W2) of Plasmodium falciparum.…”

Theoretical studies of new Schiff base ligand derived from 1,3‐diaminopropane and 2‐acetyl ferrocene and studying some applications of its metal complexes

“…It was supposed that cyclopentadiene transition metal compounds formed a link between organometallic chemistry to medicine, biology and molecular biotechnology . Ferrocenyl derivatives were used as bioactive molecule which was established recently and several reports showed that a large number of ferrocene containing compounds have interesting cytotoxic and DNA cleaving activities . So, a challenge to prepare a new Schiff base ligand from coupling of 2‐acetylferrocene with 1,3‐diaminopropane was considered and explore its applications.…”