Ferritin Nanocage Conjugated Hybrid Hydrogel for Tissue Engineering and Drug Delivery Applications

Samanipour, Roya; Wang, Ting; Werb, Moritz; Hassannezhad, Hamed; Rangel, Juan Manuel Ledesma; Hoorfar, Mina; Hasan, Anwarul; Lee, Chang Kee; Shin, Su Ryon

doi:10.1021/acsbiomaterials.9b01482

Cited by 29 publications

(30 citation statements)

References 47 publications

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“…Moreover, a cumulative release test of small molecules on fluorescein isothiocyanate (FITC) encapsulated apoferritin and ApoMA incorporated GelMA hydrogels by pH stimulus was performed. The nanocage incorporated hydrogels showed excellent potential for tissue engineering and drug delivery (Samanipour et al, 2019 ).…”

Section: Applications Of Hybrid Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Cai

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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The applications of hydrogels in biomedical field has been since multiple decades. Discoveries in biology and chemistry render this platform endowed with much engineering potentials and growing continuously. Novel approaches in constructing these materials have led to the production of complex hybrid hydrogels systems that can incorporate both natural and synthetic polymers and other functional moieties for mediated cell response, tunable release kinetic profiles, thus they are used and research for diverse biomedical applications. Recent advancement in this field has established promising techniques for the development of biorelevant materials for construction of hybrid hydrogels with potential applications in the delivery of cancer therapeutics, drug discovery, and re-generative medicines. In this review, recent trends in advanced hybrid hydrogels systems incorporating nano/microstructures, their synthesis, and their potential applications in tissue engineering and anticancer drug delivery has been discussed. Examples of some new approaches including click reactions implementation, 3D printing, and photopatterning for the development of these materials has been briefly discussed. In addition, the application of biomolecules and motifs for desired outcomes, and tailoring of their transport and kinetic behavior for achieving desired outcomes in hybrid nanogels has also been reviewed.

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Section: Applications Of Hybrid Hydrogelsmentioning

confidence: 99%

“… Ferritin nanocage conjugated hybrid hydrogel for tissue engineering and drug delivery applications. reproduced with permission from Samanipour et al ( 2019 ). Copyright (2019) American Chemical Society.…”

Section: Applications Of Hybrid Hydrogelsmentioning

confidence: 99%

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Cai

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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“…Nanomaterials have also been used to improve the performance of GelMA in drug delivery. Samanipour et al [40] fabricated nanocage-laden GelMA hydrogels to overcome the shortcoming of GelMA in uncontrollable drug release. The drug release of nanocage-laden GelMA hydrogels can be controlled by adjusting pH value (this hydrogels shows drug storage potential at pH 7.4 and presented the ability of controlled-release at pH 2).…”

Section: Gelma For Drug Deliverymentioning

confidence: 99%

Biomedical application of photo-crosslinked gelatin hydrogels

Xiang

Cui

2021

J Leather Sci Eng

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During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field. Graphical abstract

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“…Since precursor solution of injectable gel can easily entrap bioactive molecules and living cells, then the solution can be injected into the body to form hydrogel entrapping bioactive molecules and cells, injectable gel has potential to provide scaffolds to cells for in vivo tissue regeneration with a minimally invasive implantation procedure. While many types of hydrogel scaffolds using a wide variety of biological/synthetic and organic/inorganic molecules have been reported, [ 19–25 ] in vivo tissue engineering using hydrogel scaffolds mostly remains experimental with limited human trials. For this reason, we conceived that the validities of the current major tendencies in the design of hydrogel scaffolds should be reconsidered.…”

Section: Figurementioning

confidence: 99%

Covalent Cell‐Loading Injectable Hydrogel Scaffold Significantly Promotes Tissue Regeneration In Vivo Compared with a Conventional Physical Cell‐Loading Hydrogel Scaffold

et al. 2021

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Currently, one of the major tendencies to be adopted for the design of hydrogel scaffolds in tissue engineering include that cells are loaded physically into the pores of 3D hydrogel networks. In this study, a drastic deviation from this tendency is proposed and developed a new type of hydrogel scaffold in which cells are covalently connected to 3D hydrogel networks via bioorthogonal click cross‐linking reactions of azide‐modified cells with alkyne‐modified polymers. The purpose of this study is to directly compare the utility of the covalent cell‐loading approach and the conventional physical cell‐loading approach as hydrogel scaffolds for in vivo tissue engineering. It is found that the proposed covalent cell‐loading approach significantly promotes tissue regeneration and functional recovery in vivo in comparison with the conventional physical cell‐loading approach. This is the first report demonstrating the importance of the covalent cell‐loading approach in tissue engineering. This covalent cell‐loading approach is applicable to a broad spectrum of mammalian cells, including stem cells. The present findings provide a promising new route to generate innovative hydrogel scaffolds for in vivo tissue engineering.

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Ferritin Nanocage Conjugated Hybrid Hydrogel for Tissue Engineering and Drug Delivery Applications

Cited by 29 publications

References 47 publications

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering

Biomedical application of photo-crosslinked gelatin hydrogels

Covalent Cell‐Loading Injectable Hydrogel Scaffold Significantly Promotes Tissue Regeneration In Vivo Compared with a Conventional Physical Cell‐Loading Hydrogel Scaffold

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