Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload

Jacobs, A.; Miller, F.; Worwood, Mark; Beamish, M. R.; Wardrop, C. A. J.

doi:10.1136/bmj.4.5834.206

Cited by 490 publications

(192 citation statements)

References 3 publications

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“…In patients with very low serum ferritin concentrations 1<5 ~g/L), all had reduced serum iron and the transferrin saturation was below 0.16 in 5 out of 6 patients. A transferrin saturation under 0.16 is considered to be a reliable indicator for iron deficiency, provided anemia of chronic disease is excluded (25L Jacobs et al (26) reported that serum ferritin concentrations below 10 ~g/L were associated with transferrin saturation under 0.16. The difference in nominal ferritin values is probably due to lack of standardization because our normal values were about half of those presented by Jacobs et al (26 ~.…”

Section: Discussionmentioning

confidence: 99%

Measurement of ferritin in serum: Application in Diagnostic use

Oost¹,

Beld²,

Cloin³

et al. 1984

Clinical Biochemistry

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A sandwich-type radioimmunoassay for serum ferritin was developed using iron-rich human liver ferritin and evaluated for its clinical usefulness. In young healthy males and females, the mean serum ferritin concentrations were 44 ~g/L (range 7-158) and 16 p.g/L (range 4-56), respectively. In anemic patients lower serum ferritin concentrations were found, while in most patients with iron overload serum ferritin concentrations well above 1000 ~g/L were measured. Comparison of our method with a commercially available radioimmunoassay kit revealed a good correlation, except for sera with very low ferritin concentrations. Comparison with serum iron and transferrin parameters in patients with iron deficiency demonstrated that serum ferritin concentrations might be subnormal in a majority of patients with otherwise normal iron indices. Up to 70% of the ferritin in serum of normal subjects could bind to concanavalin A-Sepharose, indicating its glycoprotein nature. It is concluded that our serum ferritin radioimmunoassay gave reliable results and was useful in the laboratory diagnosis of latent iron-deficiency and in the analysis of the heterogeneity of serum ferritin.

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Section: Discussionmentioning

confidence: 99%

Measurement of ferritin in serum: Application in Diagnostic use

Oost¹,

Beld²,

Cloin³

et al. 1984

Clinical Biochemistry

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“…Ferritin is also present in serum and the level of circulating ferritin is directly related to body stores of iron [2,10,15]. Tissue ferritin injected into the vein is rapidly taken up by the liver, in which ferritin receptors are present [1].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in bovine theileriosis, the excess iron processed by erythrophagocytosis in the liver and spleen may be stored mainly in hepatocytes through such mechanisms as described above. The elevated serum ferritin level in the T. sergenti-infected cattle is considered to reflect apparently increased body iron stores [2,10,15].…”

Section: Discussionmentioning

confidence: 99%

Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Watanabe

Ozawa

Ochiai

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. Changes in iron and ferritin in calves infected with Theileria sergenti were investigated to elucidate iron metabolism in animals with extravascular hemolytic anemia. During severe anemia, serum iron was remarkably elevated while the total iron-binding capacity remained relatively unchanged or decreased slightly in the infected calves, resulting in elevated transferrin saturation. The serum ferritin concentration gradually increased with the progress of anemia. The erythrocyte ferritin content drastically increased when mean corpuscular volume was elevated. The concentration of non-heme iron and ferritin in the liver, spleen, and bone marrow of the infected calves was markedly higher than that in the respective tissues of the control animals. In particular, the liver of the anemic calves was found to contain 23 and 35 times as much non-heme iron and ferritin, respectively, as that of the non-anemic healthy cattle. The liver type (L) to heart type (H) subunit ratio of liver ferritin was significantly higher in the protozoa-infected than in the non-infected cattle. On the other hand, the L/H ratio of marrow ferritin was significantly reduced by the anemia. These results indicate that the anemic calves infected with T. sergenti apparently present symptoms of iron overload. -KEY WORDS: anemia, calf, ferritin, iron, Theileria sergenti.

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“…Formulas have been devised to estimate iron stores from concentrations of serum ferritin in healthy individuals (Cook & Finch, 1979;Cook et al, 1986). The introduction of serum ferritin for the evaluation of the iron status (Addison et al, 1972;Jacobs et al, 1972) was a marked diagnostic improvement since low serum ferritin concentrations are only seen in iron de®ciency, indicating an absence of iron stores. Low serum ferritin is not associated with any other known condition (Walters et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Effect of a mild infection on serum ferritin concentration—clinical and epidemiological implications

Hulthén

Lindstedt

et al. 1998

Eur J Clin Nutr

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Objectives: To study the distribution of serum ferritin concentration in adolescent boys and girls with and without a preceding mild infection. Design: The prevalence of iron de®ciency was studied in two representative samples. The ®rst sample from 1990 comprised 207 boys and 220 girls. The second sample from 1994 included 620 boys and 624 girls. In total 1675 adolescents, 15±16 y old, 827 boys and 844 girls were studied. Results: A signi®cant shift of serum ferritin concentration towards higher values was observed in those who reported an upper respiratory infection with fever during the preceding month (P`0.001). Signi®cant differences were found between serum ferritin values in healthy, not infected adolescents and serum ferritin values in those with ongoing infection, both in boys and girls in the two materials (P`0.01), and in those with a mild infection during the preceding three weeks. Conclusions:The prevalence of recent infection should be included as information when trying to assess the prevalence of iron de®ciency on the basis of serum ferritin measurements and when examining relationships between iron status and composition of the diet. The ®ndings imply that differences in prevalence of iron de®ciency between different studies might partly be explained by differences in prevalence of simple respiratory infections. The diagnostic sensitivity of the serum ferritin assay for iron de®ciency, using conventional reference limits, decreases for subjects with recent such infections; similarly, there will be a decrease in the diagnostic speci®city for haemochromatosis. Sponsorship: Swedish Medical Research Council (project B9519X-04721-20B) and Swedish Dairy Association, Stockholm. Descriptors: serum ferritin concentration; mild infection; adolescents; prevalence of iron de®ciency; diagnostic sensitivity and speci®cityairon de®ciency; iron overload

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Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload

Cited by 490 publications

References 3 publications

Measurement of ferritin in serum: Application in Diagnostic use

Measurement of ferritin in serum: Application in Diagnostic use

Changes in Iron and Ferritin in Anemic Calves Infected with Theileria sergenh.

Effect of a mild infection on serum ferritin concentration—clinical and epidemiological implications

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