Ferritin for the clinician

Knovich, Mary Ann; Storey, Jonathan A.; Coffman, Lan; Torti, Suzy V.; Torti, Frank M.

doi:10.1016/j.blre.2008.08.001

Cited by 482 publications

(437 citation statements)

References 87 publications

(79 reference statements)

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“…4,10,15,32 There is a possibility that the adverse prognostic impact of pre-HSCT hyperferritinemia may be related to factors independent of iron overload. 12,31 The laboratory sign of iron overload is ferritin elevation in the presence of increased transferrin saturation.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

Malkan¹

2016

UHOD

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The impacts of serum iron parameters and/or radiological evidence of systemic iron overload on the prognosis of hematopoietic stem cell transplantation (HSCT) in acute leukemia are controversial. Unfortunately, some of the studies evaluating iron overload in transplant setting did not precisely show the patients with iron overload, mainly due to ignoring consideration of transferrin saturation along with hyperferritinemia for elimination of non-iron overload etiologies of hyperferritinemia. The aim of this study is to assess the effect of iron overload on transplantation related complications and prognosis in acute leukemia. Patients who undergone allogeneic HSCT for acute leukemia in Hacettepe University Medical School Department of Hematology were screened retrospectively in order to find cases with serum iron tests within 9 months before transplant. The endpoints investigated were overall and disease-free survivals, acute and chronic graft-versus-host disease and veno-oclussive disease (VOD). There were 84 patients suitable for inclusion. When various ferritin plus transferrin saturation (TS) cut-off values were investigated for a possible relationship with major transplant-related complications/results only ferritin> 2000 plus TS> 45% was found to have an association with VOD at borderline significance (p= 0.067). In conclusion, we observed a non-significant borderline relationship between iron overload and post-transplant VOD. We did not confirm other post-transplant complications reported in the literature. It must be noticed that although many studies intended to investigate the relationship between iron status and transplant outcomes, only a few of them have really looked for the effect of iron overload. Keywords: Iron overload, Acute leukemia, Transplantation ÖZET Akut Löseminin Prognozu ve Transplantasyonla İlişkili Komplikasyonlarına Demir Yükselmesinin EtkisiSerum demir parametrelerinin ve/veya radyolojik olarak saptanan sistemik demir yüklenmesinin, kök hücre nakli (KHN) yapılmış akut lösemi hastalarının prognozuna olan etkisi tartışmalıdır. Ne yazık ki, demir yüklenmesinin transplantasyona olan etkisini araştıran bazı çalışmalarda demir yüklenmesi olan hastalar doğru bir şekilde saptanamamıştır. Bunun nedeni hiperferritineminin demir yüklenmesi dışındaki sebeplerinin göz ardı edilmesidir. Bu çalışmanın amacı, demir yüklenmesinin akut lösemi hastalarının prognozuna ve transplantasyon ile ilişkili komplikasyonlarına olan etkisinin araştırılmasıdır. Transplantasyon öncesi dokuzuncu aya kadar olan serum demir testleri olan hastaları bulmak amacıyla, Hacettepe Üniversitesi Tıp Fakültesi Hematoloji Departmanı'nda allojenik KHN yapılan hastalar retrospektif olarak taranmıştır. Çalışma sonlanım noktaları, genel ve hastalıksız sağkalım süreleri, akut ve kronik graft versus host hastalığı ve venookluziv hastalıktır (VOH). Çalışmaya alınma kriterlerine uyan 84 hasta mevcuttu. Transplant ilişkili komplikasyonlar ile demir yüklenmesi arasında bir ilişki bulabilmek amacı ile transferrin satürasyonu (TS) ...

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Section: Discussionmentioning

confidence: 99%

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

Malkan¹

2016

UHOD

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“…Залізо є необхідним для багатьох життєво важливих функцій, таких як транспорт кисню, пе-ренос електронів, синтез ДНК, поділ клітин [14,15]. У процесі канцерогенезу надлишок заліза сприяє утворенню активних форм кисню, які викликають пошкодження ДНК.…”

Section: об'єкт і методи дослідженняunclassified

STATE AND PROSPECTS OF IMPLEMENTATION NANOTECHNOLOGY IN BIOLOGY AND MEDICINE Information from scientific report at the meeting of Presidium of NAS of Ukraine, April 29, 2015

Чехун¹

2015

Visn. Nac. akad. nauk Ukr

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“…Recent advances have shown that ferritin has roles beyond the storage of iron, such as modulation of inflammation, DNA binding and neuro-degeneration [5][6][7]. Production of ferritin is under tight control and several factors regulate its expression, including cytokines, growth factors, hormones, ischemia and oxidative stress [8].…”

Section: Introductionmentioning

confidence: 99%

Serum ferritin as an activity marker for granulamotosis with polyangiitis

et al. 2017

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Background: Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis. Methods: Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Serum ferritin and other acute phase markers were measured at initial presentation. Results: Serum ferritin levels were found to be the highest in GPA patients with alveolar hemorrhage, median (IQR) 1041 (1281) lg/L. Patients with renal disease also had high levels of ferritin and it was correlated with concurrent glomerular filtration rate (r ¼ À0.65, p < .001). Serum ferritin is also correlated well with the BVAS/WG scores (r ¼ 0.79, p < .001). Conclusions: Measurement of serum ferritin might help in assessing disease activity of GPA.

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Ferritin for the clinician

Cited by 482 publications

References 87 publications

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

The Impact of Iron Overload on Transplant-Related Complications and Prognosis of Acute Leukemias.

STATE AND PROSPECTS OF IMPLEMENTATION NANOTECHNOLOGY IN BIOLOGY AND MEDICINE Information from scientific report at the meeting of Presidium of NAS of Ukraine, April 29, 2015

Serum ferritin as an activity marker for granulamotosis with polyangiitis

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