Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial

Abstract

Two 750-mg infusions of FCM are a safe and effective alternative to multiple lower dose iron sucrose infusions in NDD-CKD patients with iron-deficiency anemia.

Correcting iron deficiency

“…The study demonstrated that ferric carboxymaltose was safe, effective and required fewer doses making it potentially more cost-effective than iron sucrose. 19 Other studies have also found favourable cost-effectiveness. 20 One limitation is ferric carboxymaltose can only be infused in doses up to 1 g per week.…”

“…Full text free online at nps.org.au/australianprescriber VOLUME 39 : NUMBER 6 : DECEMBER 2016 REPAIR-IDA 19 reported a higher incidence of mild adverse events in patients treated with ferric carboxymaltose compared to iron sucrose. These included mild hypersensitivity reactions, nausea and flushing, however there was no statistically significant difference on the pre-specified safety end points.…”

An Emerging Treatment Alternative for Anemia in CKD Patients: A Review on Daprodustat

“…Anemia in CKD patients may be caused by iron deficiency, inflammation, or a disruption in the production of erythropoietin (EPO) [2,3]. Erythropoietin is a hormone that stimulates the production of red blood cells [4]. Deficiencies of this hormone are currently managed with erythropoietin stimulating agents [ESAs], usually in combination with iron supplementation.…”

A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat

“…An important function of the kidneys is the production of erythropoietin, a hormone that stimulates production of red blood cells [1][2][3]. The kidneys produce this hormone in response to oxygen tension and extracellular volume [3].…”

“…The kidneys produce this hormone in response to oxygen tension and extracellular volume [3]. In disease states such as Chronic Kidney Disease (CKD) the kidneys are not functioning at capacity and there can be a disruption in the production of erythropoietin that can lead to anemia [1,2]. Other causes of anemia in CKD are iron deficiency and inflammation.…”